S..
To ?
SENATE
SiMON FRASER UNIVERSITY
?
S.
MEMORANDUM
From
SENATE COMMITTEE ON UNDERGRADUATE
STUDIES
Subject
REVISED' PROGRAM INBIO-CHEUSTY
?
I
Date JUNE 18, 1974
MOTION 1: "That Senate approve, as set forth in S.744,
the proposed Calendar entry covering the core
program requirements for bio-chemistry majors,
and descriptions of courses."
MOTION 2: "That Senate approve, as set forth in S.74-,
new course proposals for:
BICH 301-3 - The Structure and Reactivity of Biomolecules
BICH 302-2 - Metabolism
BICH 311-2 - Analytical Biochemistry Laboratory
BICH 312-2 - Metabolism Laboratory
BICH 403-3 - Physical Biochemistry
BICH 411-2 - Enzymology Laboratory
BICH 413-2 - Physical Biochemistry Laboratory
BICH 420-3 - Selected Topics in Contemporary Biochemistry
BICH 490-3 - Directed Study in Advanced Topics of Biochemistry
BICH 491-5- Undergraduate Research."
MOTION 3: "That Senate'approve, as set forth
in
S.74-c,
that the following courses be discontinued
over time:
CHEM 421-3 - Descriptive Bio-Chemistry
CHEM 422-3 - Physical Blo-Chemistry
CHEN 426-2 - Bio-Chemis try Laboratory I
CHEM 427-2 - Bio-Chemistry Laboratory II."
MOTION 4: "That Senate waive 'the normal two semester time
lag requirement in order that BICH 301-3, 311-2,
490-3, and 491-5 may be first offered in the
Fall semester 1974, and that BICH 302-3, 312-2,
. ?
403-3 and 420-3 may be first offered in the
Spring semester 1975."
0
At its meeting of 11th June, 1974, the Senate
Committee on Undergraduate Studies considered the revised
Blo-Chemistry program and recommends approval to Senate.
This recommendation includes:
1.
the proposed Calendar entry covering the core program,
requirements for bio-chemistry majors, requirements
for bio-chemistry honors and descriptions of courses;
2. new courses - BICH
301-3
- The Structure and Reactivity
of Biomolecules
BICH
302-2
- Metabolism
BICH
311-2
- Analytical Biochemistry Laboratory
• ? BICH
BICH
312-2
403-3
- Metabolism Laboratory
- Physical Biochemistry
BICH
411-2
- Enzymology Laboratory
BICH
413-2
- Physical Biochemistry Laboratory
BICH
420-3
- Selected Topics in Contemporary
Biochemistry
BICH
490-3
- Directed Study in Advanced Topics
of Biochemistry
BICH
491-5 - Undergraduate Research; and
3.
the discontinuing of the following courses:
CHEM 421-3 - Descriptive Bio-Chemistry
CHEM 422-3 - Physical Bio-Chemistry
CHEM 426-2 - Bio-Chemistry Laboratory I
CHEM 427-2 - Bio-Chemistry Laboratory II
The Committee further recommends that, if the
revisions to the Bio-Chemistry program are approved, the normal
two semester time-lag requirement be waived in order that BICH 301-3,
311-2, 490-3, and 491-5 may be first offered in the Fall semester
1974 and that BICH 302-3, 312-2, 403-3 and
4203
may be first offered
in the Spring semester, 1975.
The Committee was informed that arrangements were
being made within the Faculty of Science for the change over from
.
?
the old to the revised program and that, while it was the wish of
the Faculty to effect this change as quickly as possible, it may
be necessary to phase out gradually the four Chemistry courses which
are to be discontinued so that those students who have declared for
an honors or major program in Bio-Chemistry could be accommodated
under existing arrangements. The Committee also examined the
I
S
?
.2
question of relationship of the proposed program to that of the
Department of Kinesiology. It was informed that two Faculty
from the Kinesiology Department had been members of the Bio-
Chemistry Committee and that extensive consultation had taken
place between the Committee and that Department in determining
the question of overlap between the proposed Bio-Chemistry
courses and those of the Kinesiology Department.
I. Mugridge
ams
att.
S
0
SiMON FRASER UNIVERSITY
SC US
74-22
MEMORANDUM ?
As approved by SCUS
June 11, 1974
To .........................
?
ateCommittee ..n
?
.............................
From
..............S.
?
Aronoff
...............Undergra4teStudies
?
..............................Pea.ofence
Subject............... REVI.SE.DBIOCHEMISTRY .,PRp.GRAN
?
.Date.....ay27.1q74
Attached is the revised Biochemistry Program as approved by the Faculty
of Science at its meeting of May 16, 1974. Part I contains the revised
Biochemistry Curriculum, complete with proposed calendar entry, new course
proposal forms, and
accompanying
course outlines as required. Part II
outlines the proposed changeover procedures and frequency of the offering
of the new courses. Part III
contains
details of the administrative
structure of the Biochemistry Curriculum Committee, which is directly
responsible for the development and implementation of the Biochemistry
Program.
I should like to emphasize that this is a
revised,
and
not a new Program.
(It should therefore
not
go
to the Academic Planning Committee.) The
revision has consisted of an extensive reshuffling of subject matter
within the Chemistry courses so that they may be presented in a manner
. ?
consistent with the progress in Biochemistry over the last decade. A
further evaluation and reconsideration of Bio-Science 401 and 402 will
occur during the coming year.
It is recommended that the Faculty of Science be granted a special dispensation
in order that the new program be implemented in the Fall Semester, 74-3.
1w
".
..
I,,
.
PART
REVISED BIOCHEMISTRY CURRICULUM
0
BIOCHEMISTRY CURRICULUM?
Calendar Entry
A Major and Honors degree program in Biochemistry is offered by
the Faculty of Science. Entry into these programs requires the
permission of the Biochemistry Committee of the Faculty of Science.
All students taking Biochemistry must complete the "Core Program"
as specified below, together with elective courses chosen in
consultation with the Biochemistry faculty.
CORE PROGRAM
(78 semester hours)
Biochemistry
301-3, ?
302-3, ?
311-2,
?
312-2,
?
403-3, ?
411-2,
and 413-2.
Bio-Science 20 ?
hours, ?
to ?
include ?
202-3, ?
302-3,
?
401-33%
and 402-3. ?
101-4 and 102-4 are strongly
recommended.
Chemistry
104-3,
?
105-3, ?
115-2, ?
117-2, ?
233-2, ?
251-3,
252-3, ?
256-2, ?
261-3, ?
and ?
356-2.
Mathematics
151-3, ?
152-3, ?
and ?
253-4.
Physics
101-3 and 102-3.
?
Students who intend to enter
graduate studies in biochemistry are advised to
take ?
201-2, ?
202-2, ?
203-2, ?
204-2, ?
and 205-2 instead.
BIOCHEMISTRY
MAJORS ?
(120 semester hours)
In addition to the "Core Program", students majoring in Biochemistry
must complete an additional 42 semester hours of electives, at
least 6 of which must be outside the Faculty of Science, and at
least 16 of which should be upper division (i.e. 300 and 400
•
?
level) courses.
A1thoug1 many variations are possible, a student entering with
Chemistry 12, and Physics 11 (or equivalents) might take the
following typical program.
-2-
Levels 1 and 2
?
Bio-Science 101-4 and 102-4
Chemistry 104-3, 105-3, 115-2, and 117-2
Mathematics 151-3 and 152-3
6 hours of electives
Total 30 hours.
Levels 3 and 4
?
Bio-Science 202-3
Chemistry 251-3, 25243, 256-2, and 356-2
Mathematics 253-4
Physics 101-3 and 102-3
7 hours of electives
Total 30 hours.
Levels 5 and 6
?
Biochemistry 301-3, 302-3, 311-2, and 312-2
Bio-Science 302-3
Chemistry 233-2 and 261-3
12 hours of electives
0
?
Total 30 hours.
Levels 7 and 8
?
Biochemistry 403-3, 411-2, and 43-2
Bio-Science 401-3 and 402-3
17 hours of electives
Total 30 hours.
Students entering without the equivalent of Chemistry 12 may not
enter Chemistry 104-3, but may begin with Chemistry 101-3 and
106-2 and then follow a program similar to the above. Students
with Biology 11 may omit Bio-Science 101-4 and students with
Biology 12 may omit both Bio-Science 101-4 and 102-4 and substitute
the equivalent number of Bio-Science electives if they wish.
BIOCHEMISTRY HONORS
?
(132 semester hours)
In addition to the "Core Program" students taking honors in
. ?
Biochemistry must complete an additional 54 semester hours as
follows: Biochemistry Research (Biochemistry 491-5) and 49
semester hours of electives. At least 6 hours of electives must
-3-
S ?
be outside the Faculty of Science and at least 27 should be upper division
(i.e. 300 and 400 level) courses of which at least 15 complement a coherent
area of specialization approved by the Biochemistry Committee.
KINESIOLOGY ELECTIVES
The student's attention is drawn to the following biochemistry-related
courses offered by the Department of Kinesiology In the Faculty of Inter-
disciplinary Studies. Any of these 'courses may be included in the 42
semester hours (or 49 for honors students) of electives:
Kinesiology 100-3, 200-3, 326-3, 330-3, 336-3, 402-4, 404-5,
405-3, 407-3.
DESCRIPTION OF COURSES
It is intended that Biochemistry Majors or Honors students will take the
Biochemistry courses in the order presented under the Recommended Program
above, and with the prescribed prerequisites. However, students in other
majors and honors programs may be admitted into any of these courses at the
S ?
discretion of the Biochemistry Committee.
Note: Students with credit for CHEM 421-3 and CHEM 422-3 cannot take BICH
301-3 and BICH 302-3 for further credit. Those with credit for CHEM
426-2 and CHEM 427-2 cannot take BICH 311-2 and BICH 312-2 for
further credit. Those with other combinations in these courses may
seek advice from the Biochemistry Committee.
BIOH 301-3 - The Structure and Reactivity of Blomolecules (3-1-0)
The structure and analysis of amino acids, peptides, carbohydrates, lipids,
nucleotides, and nucleic acids; coenzyme activation; reactivity of bio-
molecules and mechanisms of biochemical reactions.
Prerequisite: Chemistry
252-3.
Biochemistry
311-2 will
ordinarily be taken
concurrently, but may be taken subsequent to BICH 301-3.
BICH 302-3 - Metabolism (3-1-0)
The major pathways of primary metabolism; bloenergetics; compartmentalization
of cellular metabolic functions; elementary control mechanisms.
Prerequisite: Biochemistry 301-3. Biochemistry
312-2 will
ordinarily be taken
concurrently, but may be taken subsequent to
BICH 302-3.
-4-
• ?
BICH 311-2 - Analytical Biochemistry Laboratory (0-0-4)
The biochemical analysis of amino acids, peptides, carbohydrates, lipids,
nucleotides, and nucleic acids.
Prerequisite: Chemistry
256-2.
Biochemistry
301-3 will
ordinarily be taken
concurrently, but may precede
BICH 311-2.
BICH 312-2 - Metabolism Laboratory (0-0-4)
Experiments demonstrating the major energy yielding processes of metabolism
and selected biosyntheses.
Prerequisite: Chemistry
256-2.
Biochemistry
302-3 will
ordinarily be taken
concurrently, but may precede BICH
312-2.
BICH 403-3 - Physical Biochemistry (3-1-0)
The physical properties of biopolymers and their use in molecular weight and
structure determinations; modern methods of purification of proteins and
nucleic acids; properties of membranes and methods of membrane analysis and
study.
.
?
Prerequisites: Physics
102-3
(or Physics
202-2
and
204-2),
Math
253-4
and
Biochemistry
301-3.
Biochemistry
413-2 will
ordinarily be taken concurrently,
but may be taken subsequent to
BICH 403-3.
BIH 411-2 - Enzymology Laboratory (0-0-4)
Experiments on enzyme kinetics, enzyme activation, an.ddrihibi.t1óh.
Prerequisite: Biochemistry
311-2
or
312-2.
Bio-Science
402-3 will
ordinarily
be taken concurrently, but may. precede
BICH 411-2.
BICH 4
.
1.3-2 -
Physical Biochemistry Laboratory (0-0-4)
Enzyme isolation and purification; the measurement of physical properties of
macromolecules; studies with bio-membranes.
Prerequisite: Biochemistry
411-2.
Biochemistry
403-3 will
ordinarily be
taken concurrently, but may precede
BICH 413-2.
BICH 420-3 - Selected Topics in Contemporary Biochemistry (3-1-0)
A course of selected topics of contemporary interest to biochemists, such as
S
drug research, pollution, cancer research., genetic engineering, aging, memory
research, etc.
Prerequisite: Pernission
of
the Biochemistry Committee. Upper levels standing
(at least 60 semester hours) in a Faculty of Science degree program will usually
be required.
.
? -5-
BICH 490-3 - Directed study In advanced Topics of Biochemistry
Directed reading In a topic chosen in consultation with a supervisor.
Prerequisite: Permission of the Biochemistry Committee. Upper levels
standing (with at least 75 semester hours) in the Biochemistry Program
will usually
be required.
BICH 491-5 - Undergraduate Research
Laboratory research for preparation of a thesis for the honors degree
In Biochemistry.
Prerequisite: Permission of the Biochemistry Committee.
.
0
Form C-7
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I
?
CALENDAR INFORMATION
Program: Biochemistry Course Number: 301 Title:
The Structure and Reactivity
of Biomolecules
Sub-title or Description:
The structure and analysis of amino acids, peptides, carbohydrates,
lipids, nucleotides, nucleic acids; coenzyme activation; reactivity of
bioinolecules and mechanisms of biochemical reactions.
Credit Hours: 3
?
Vector Description: (310)
S
0 1
Prerequisite(s): Chem. 252-3. Biochem. 311-2 will ordinarily be taken
concurrently,
but may be taken subsequent to BICH 301-3.
ENROLMENT AND SCHEDULING
Estimated Enrolment: 20
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Fall.
When course will first be offered: 74-3
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University?
It is an extension of Chem. 252 principles to biomolecules. By dropping
Chem. 421, no course content overlap will exist in the Chemistry
Department. In addition, no increased overlap will occur with courses
in the Bio-Science Department.
B.
What is the range of topics that may be dealt within the course?
cf. course outline attached.
. ?
C. How does this course fit the goals of the program?
It is of fundamental importance to the Biochemistry Program.
D. How does this course affect degree requirements?
It is a core requirement of the Biochemistry Program.
Page 2
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and
p.
260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
Chem. 421-3.
G.
What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Bio-Science and Kinesiology majors may
wish to take this course as an elective.
H.
Other reasons for introducing the course.
N/A
IV ?
BUDGETARY AND SPACE FACTORS
A.
Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by Departments
of the Faculty of Science and approved by the Chairman of the Biochemistry
Committee.
B.
What are the special space and/or equipment requirements for this course?
C.
Any other budgetary implications of mounting this course?
None
APPROVAL - Faculty Curriculum
Faculty: ?
_/._
(1f
Senate:
0
COURSE OUTLINE
BICH 301-3
The Structure and Reactivity of Biomolecules
Lect. ?
No.
Topics
1
Introductory remarks
2
Acids and amino acids--pK's,
?
titration and analysis
3
Peptide bond--synthesis of polypeptides
4
Proteins--classification and analysis
5
Proteins--forces determining the 4 levels of structure
6
Proteins and enzymes- -3-D structure
7
Enzyme mechanisms--active site participation
8
Carbohydrates--naming and structure- -hemiacetals and
acetals
9
Mono- and disaccharides--carbohydrate tests and
analysis
10
Oligo- and polysáccharides--structure and analysis
11
Simple lipids--fatty acids, fats and phospholipids
12
Complex lipids--sphingolipids, glycolipids and bacterial
cell walls
13
Isoprenoids and steroids--classification and structure
14
Purines and pyrimidines- -nucleotide formation (incl.
NAD, ?
FAD, ?
etc.)
15
Structure of RNA (t-, m-, and r-RNA)--methods of
analysis
16
Structure of DNA-base pairing and double helix--
genetic code
17
Coenzymes--classification (group transfer, redox,
etc.)
18
Hydration of double bonds and elimination mechanisms--
isomerization ?
(e.g. ?
aconitase, tautomerization,
epimerization)--enolase, fumarase,
?
aspartase,
threonine and cysteine formation
19
"High energy" and "low energy" compounds
20
Hydrolases and phosphatases--peptidases,
?
amlyases,
lipases and nucleases- -phosphorylase
21
Activation of carboxyl group--ester and amide
formation
Course Outline
BICH 301-3
Page
Lect. No. ?
Topics
22 ?
Phosphate transfer reactions--examples in glycolysis,
citric acid cycle and biosynthesis of carbohydrates,
proteins, phospholipids, nucleic acids and generation
of ATP
23 ?
Generation of nucleophiles--activation by thiamine
pyrophos., pyridoxal phos. and coenzyme A
24 ?
Claisen-type reactions--citrate, fatty acid and
mevalonate .
synthesis.
25 ?
Aldol-type reactions- -aldolase and transaldolase- -
Schiff's bases
26 ?
Acyloin-type reactions- -transketolase- -decarboxylations
with thiamine pyrophosphate (compare with -ketoacid
decarboxylat ion)
27 ?
Pyridoxal phosphate/aminoacid reactions- -transamination,
etc.
28 ?
One-carbon coenzymes- -tetrahydrofolic acid, vitamin
B 121
S-adenosylmethionine, biotin, carbamyl phosphate
29 ?
Dehydrogenase coenzymes--NAD('), flavins, lipoic
41 ?
acid, GSH
30 ?
Redox reactions of alcohols/ketones and amines/imines
couples
31 ?
Redox reactions of aldehydes/acids--oxidative
decarboxylation of ct-ketoacids
32 ?
Major energy yielding mechanisms in citric acid
cycle and s-oxidation
33 ?
Other redox coenzymes--hemoproteins, metallo-
flavoproteins, non-heme iron and copper proteins
34 ?
Hydroxylases and oxidases- -function of biopterin
and ascorbic acid
35 ?
Electron transport chains--quinones, cytochromes,
ferredoxin, cytochrome oxidase- -examples of alternate
inorganic acceptors
is
F.
Form C-7
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I ?
CALENDAR INFORMATION
Program: Biochemistry
?
Course Number: 302
Title: Metabolism
Sub-title or Description:
The major pathways of primary metabolism; bioenergetics; compartmentalization
of cellular metabolic functions; elementary control mechanisms.
Credit Hours: 3
?
Vector Description: (3-1-0)
Pre-requisite(s): Biochemistry 301-3, Biochemistry 312-2 will ordinarily
be taken concurrently, but
may
be taken subsequent to
BICH 302-3.
II ENROLMENT AND SCHEDULING
.
?
Estimated Enrolment: 20
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Spring.
When course will first be offered: 75-1
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments iz the University?
By dropping Chem 421 and 422, no course content overlap will exist in the
Chemistry Department. Some 30-32% overlap of course content with Bisc 301
and to a lesser extent with Bisc 201 will exist in the Bio-Science
Department. cf
. paper B-73-6 appended.
B.
What is the range of topics that may be dealt with in the course?
cff course outline attached.
C.
How does this course fit the goals of the program?
It is of fundamental importance to the Biochemistry Program.
D.
How does this course affect degree requirements?
It is a core requirement of the Biochemistry Program.
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Bthochemistry Program (cf. attached) for current
descriptions on p. 245 and
p.
260.
Page 2
• ?
F. What course, if any, is being dropped from the calendar if this course
is approved?
Chem. 422
G.
What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Bio-Science and Kinesiology majors may
wish to take this course as an elective.
H.
Other reasons for introducing the course.
N/A
IV ?
BUDGETARY AND SPACE FACTORS
A.
Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by Departments
of the Faculty of Science and approved by the Chairman of the Biochemistry
Committee.
B.
What are the special space and/or equipment requirements for this course?
None
C.
Any other budgetary implications of mounting this course?
None
APPROVAL - Faculty Curriculum
Faculty:
Senate:
S
S
COURSE OUTLINE
BICH 302-3
?
Metabolism
?
Lect. ?
No. ?
Topics
?
1 ?
Introduction- - the use of G° and E° values
?
2 ?
Review of cytology
?
3 ?
Digestion of food by an animal--breakdown of large
MW compounds and transport of small MW compounds to
cells-
-
the function of lysosomes in cells
?
4 ?
Carbohydrate activation and interconversion- -
polysaccharide synthesis.
?
5 ?
Glycolysi,s- -substrate level phosphorylation- -
pacemaker enzyme
?
6 ?
Reversal of glycolysis- -glycogen formation and
breakdown with phosphorylase- -metabolic control of
insulin and cyclic-AMP- lactic acid fermentation
?
7 ?
Phosphogluconate pathway- -NADPH generation
?
8 ?
Other pathways of carbohydrate metabolism--examples
of bacterial and yeast fermentation, Entner-Doudoroff
pathway, ascorbic acid metabolism, etc.
?
9 ?
Outer and inner membrane structure of mitochondria--
ion transport
?
10 ?
Citric Acid Cycle--reactions and bioenergetics
?
11 ?
s-Oxidation of fatty acids- -including, odd
number, unsaturated, and methyl-branched fatty acids
?
12 ?
Catabolism of aliphatic amino acids--urea cycle
?
13 ?
Tetrahydrofolic acid one-carbon pool and methionine
formation- -choline-ethanolamine cycle
?
14 ?
"Mixed-function" oxygenase of the smooth endoplasmic
reticulum- -oxidation of amines and catabolism of
aromatic amino acids and nucleotide bases
15 Location, compartmentalization, integration and control
of mitochondrial and'"microsomal" reactions--comparison
of electron transport chains from both membranes
?
16 ?
Work on the isolation of ETC complexes--bioenergetics
of ETC
17 ?
Oxidative phosphorylation mechanisms- -chemiosmotic,
mechanical and chemical coupling--work with uncouplers
and other inhibitors
18 ?
Glyoxylate and dicarboxylic acid cycle- -peroxisomes
of plants
S
Course Outline
BICH 302-3
Page
Lect. ?
No.
Topics
19
Thylakoid membrane structure of chioroplasts
20
Light reactions of photosynthesis--two phtosystems
21
Dark reactions of photosynthesis- -electron transport
chain, photophosphorylation and photoreduction of
NADP
22
Dark reactions of photosynthesis--carbon dioxide
fixation and Calvin-Basshain Cycle
23
Biosynthesis of fatty acids--elongation in the mito-
chondria and introduction of unsaturation
24
Phospholipid, sphingolipid and other complex lipid
synthesis
25
Mevalonate synthesis--ketone body formation
26
Isoprenoid and steroid synthesis
27
Nitrogen and sulfur cycles--nitrate and sulfate
reduction- -transamination with glutamate- -synthe.sis
of Glu, Asp and Ala--synthesis of Gln and Asn
28
Synthesis and control of triose family (Gly, Ser,
and Cys) and glutamate family (Pro, Ornithine and
Arg) of amino acids
29
Synthesis. and control of aspartate and branched-chain
family of amino acids
?
(Lys, Met, Thr,
?
lie, Val, Leu
and pantothenate)
30
Synthesis and control of shikimic acid family (Phe,
Tyr and Typ) of amino acids
31
Synthesis and control of histidine and purine nucleotides
32
Synthesis and control of pyrimidine nucleotides--
deoxyribonucleotide formation--overall regulation
of nucleotide synthesis
333
Nucleic acid synthesis--replication and transcription
in the nucleus--function of the nucleolus
34
Protein synthesis--translation at the ribosomes- -
the function of the rough endoplasmic reticulum
and the golgi complex
35
Examples of other biosyntheses--heme and chlorophyll,
vitamines, ?
antibiotics, ?
alkaloids, ?
hormones, etc.
SiMON FRASER UNIVERSITY
MEMORANDUM
To ..................... Biochemistry
... Committee ........ .............. .................... .
?
From ............. .J.. ..Rahe,, Chairman
...
Fauy
Qf...Sifle
...
.................................................
Sublect
.......................................... .............................. ............................... ......
BiochemistrySubcomm.ittee
?
Date
............. ...
March ...2...,....19.7.3. ............................................ ..............
It has been said that the respective syllabi for BISC-301 (Biochemistry
I) and proposed BICH-302 '(Metabolism) suggest substantial overlap between
the two courses. Discussions among the Faculty members who are teaching
or are projected to teach these courses and with two students who have
recently taken both BISC-301and CHEM-421 (somewhat similar to proposed
BICH-302) indicate that the overlap is more apparent than real. By
analogy, the similarities and differences would appear to be somewhat
like those embodied in treatments of principles of aerodynamics for
aircraft pilots and those for aeronautical engineers.
This document attempts to analyze the course syllabi for BISC-301 and
proposed BICH-302 and to quantitatively express the degree of overlap which
actually exists. Procedure for analysis of subject material in the
respective courses is as follows:
1.
Major topic areas are identified ("macro-analysis").
2.
In those major topic areas covered in both courses, specific
subtopics are identified and quantitated on the basis of
number of lecture hours allotted in each course ("micro-analysis").
3.
In each analysis, the number of hours essentially duplicated
in the respective courses is identified and expressed as a
percentage of the total course lecture hours (35).
It is recognized that some topics may be covered but not identified.
For example, integration, regulation, and control of metabolic processes
may be discussed as an integral part of coverage of the processes themselves.
In some cases it is logical to presume this; in other cases it is not.
Where
it appears that material not specifically identified in one course
is in
fact covered in a fashion which duplicates identified material in
another course,
this is
considered in the analysis; otherwise, the syllabi
are taken at face value.
The results of this analysis are somewhat surprising in that they
indicate that the courses are not really similar, even on paper. Less than
30 to 32% of the subject material of each course would appear to be common
to both courses, the remaining 68 to 70% being entirely different. Of the
30 to 32% common subject matter, it is probable that emphasis is distinct
in the respective courses; however,no attempt has been made to evaluate
this.
It is hoped that this analysis will clarify opinions as to the degree
of duplication which exists and satisfy questions concerning overlap which
may be encountered in obtaining course approval for proposed BICH-302.
•
0
4.')
Lt)
•
I
-4
N
('1
-
44
44
00
-
.-4
4t
N
--4
t)
•-
-
4.'•)•.
n
'.0
44)
-
44 ?
-
LI)
ri
*
I
'0
C)44
o
I
('4
'-4
4.4)
4.'),
4.') 4.4)
44)
I
• 44)
('4
'-4
('4
'.0
Ic
4'
-44')
00
-
•-44
4c
I
-
('4 -
-4
-
Q
'Ic
-CA
-4
-t
4f
)
4.')
O
('1
LI)
('1
0
tv.)
0) ?
-
U
a)
?
00
tfl-4
4)0)
4-W
U
a)
?
-4
?
(n
?
O') N -I
?
'-4
?
0 ?
r-4 C
1
4 (
1
4 ?
L)
?
('4
I ?
I ?
I
?
I ?
I ?
I ?
I
?
I ?
(14 ?
e'.C'4
?
00
?
0
?
U ?
•-'4 ('1 •CN
?
("1
4-4
00
4
"l'
NO
('4
LI)
4.')
4.')
-4
'-4
(4-44)
U)
cd4J
Ow
0 0
0
0\0
o'P
'.0
o
N
0
cI°
'0
0
('4
0
0
e\0
(4E-U
I
I
L/)
I
'.0
I
LI)
I
-4
0
4)OU)
vi
I
I
0 âP
0
U
("1
-
01
p4)1
-
'>
41)
II
0
'.0
LI)
+
N
("1
rn
Ut
A
o
001
-4
(4
4.J
o
I
CA
o
le
o
0
o
I
Ln
UI
(l
001
-4
0
Ml
U,
1-I
0
U
0
(4
0
.t-I
(4
a)
o
(4
-
.r.4
E
' -4
4)
U)
0
"()
•r-4
a
•
u
4) 0
r-I
0
.
-H
0
(4
•0
1-1
4-)
?
04
'-4
U
a)
NCj
>'.
(4
4-
E
0
9
0
In
-4U)
00
bO
a)
(1)
-H
(4
0)
U(4
•H
4è
41)0..
(1)
• r4
U)
C/)
10)
(1)
0
X
c4
a)
41)
'0
0)
$
0
0)
(4
k
d
4
1
(4
Cl)
10
F.r1
4J
4
4è
0
.r4
41)0
10
0)
'H
cd
• r4$ . i
,
'H
0
0 1
-4'rI
U)
-i
0
r4
C/)
0)4)
0
10
0)
(1)
4->4
0
bO
.-4
a)
-4
U 0
+J
0)
0
ci
0
$-s
0.4
0
C)
0
0
4J
4
(1)
>.
•-
o
0..
U
.-)
0..
Z
06
'-4
U
X
0)
1-4
C)
a)
'-4
(4
0
Cd
(I
Cl)
44
1,-I
I
lcd
4J
C)
I
0
U)
0
-
54
-1
S
I
I
Iou
V
LI)
ca
C?P
•r-d
541
01
'-4
01
C1 4
C14
I
C
14 C
1
4
C"
I
U)
-.
I
'I'-
I
o
0
'.4
1
0
0
-4
'.4
I
vi
vi
vi
t
I
I
I
'0
0
0
('1
LI)
I
s-I
I
I
LI)
o
N-
CO
Nt
'.4
I
LI)
C'•
00
I
I
N- 00
I
-'
C'1
.-I
C'1 C 1 4
-
C)
-
-
C)
II)
t'I
01
-
—
-I
U)
I
I
-4
C'1
-
.-4
I
0
0
r-I
1+
LI)
0
'-4
I
0
C..j
I
0)
LI)
0)
LI)
LI)
0
LI)
C)
-4
u-i
('4
u-I
C/)l
I
I
u
C'
I
C-1
I
'0
('4
i
$
('4
LI)
0
N-
00
0) a)
0
U)
I
-'
lr
u-I
11
('1
u-I
C'
('4
('4
('4
('4
C'1 C'$
LI)
-
S'
0
C)
O'i
LI),
-
'--I
j
0
(1)1
C"
I
I
-I
I
I—I
I
0
0)
M
('4
u-I
-1 i
0
'.i
'.4
-1
u-lj
-4
'-I
V
p
I
(n
C-)
o
".4
1!)
"-4
4-
Cl)
0
C)
bO
•'-4
$I
C)
Cd
s-I
C)
Cl)
Cl)
•u-4
U)
U)
".4
U)
C)
.'.I
41
0
'rI
54
U)
Cd
C)
'-4
4)
5-I
0
Cd
u-4
Cd
Cl)
C)
Cd
#1
E
Cd
C-)
$4
0
•-
U)
>
0
".4
C)
• rI
UI
43
43
Cd
(n
C)
bO
4l
U
Cl)
E
,
4-'
0
0
Cd
U)
E
Cl)
U)
Cd
..
'ri
u-I
5-I
Cl)
U)
rI
04 4J
-
C
0
•r4
(1) , ?
U)
.1-4
U)
u-i
Cd
0
•r-4
C-)
d
i-
?
>'-4
II)
0
Cl)
P,
•
'ri
U)
-c(
".4
Cd
0
C/)
43
Cd
U)
4-)
.i
C)
0
U)
0,c
Cd
N
Cd
4-)
,
C)
•u-i
0
E
0
O-u-43
43
s
Cl)
Z-i
•
,-1
ci)
•,-$
C)
•
,-I4 J
Cd
Cd
U)
0
U)
--
'.4
S
'cj
C)
(I)
,
0,0
Cd
5-4
0
u-i
0
0
-H
U)
0
Cd
..-iC)
43
H Cl)
41
"
.0
4)'r4
Cl) ".4
5
'l4'1-4 •,-I
cis
Cd
(fl
-I
I
0
Cd
$-4
4J,
43
0
C)cd u-I
C)
54>-.C)
0
E
0
Cd
43
Cd
Cd
•
CdU)0
co
U)
'
'-4
>-.
U)
C)
C)
41
'
5
5-4
4-'
,0
s 0
C) 05454
C)
".4
s
bU
u4
0(dCd
0
r4
.4
C)
I
4)
00
)"
U)
()
".454
O
0
,c
4-'
'ti
540
043
Cl)
4-'
• -44 3 cd
-u--I
43
.0-IL)
C) 4-
-I-I
P4
4-1
CI)
I
UlCo
'.4
4-4
4-)
0
Z
E
o
S-i
Cd
-'.4
5-4
0
'.0
0
C'4
0 ?
0i
.
I
Lt)
I
0
U
'-4
-I
I
,-_.I
S.-.
-I
I4
01
I
C'1
I
Ô
'-4
'
0
01
I
(N
0
0 ?
01
0
VV
IV
Lf)
(N
(N
C-
I
,-4
L()
Lf)
'.0
I
0
'.0
• ?
- ?
- ?
_
)
Lt) t) K)
(N
K)
K)
,-4
-
i-4
'--4
(N
K)
O
1.47
Lt)
-1
1-4
(N
I
(N
-
I
-
I
5-
,'
?
55-I
'-4
-
'- 4
1
r-.
r4
'-
1-4
-
K)
0
r4
I
Lr)
I
A
K)
I
I
0'-4
I
I
I
I
I
it)
K)
(N(N
K)
K)
•
'-I
0
I
tt 0
-
-
0
0
(N
0
It
0 ?
(N
0
.1-I
4.)
Cd
'-4
0
p4
U)
o
'--4
0
1-4
'2)
L)
0
0
41
E-
•
'-4
U
U)
a)
Cd
-
-'-I
44
,..4
U
x
0
0
1-4
C)
U)
0
0
E
U)
p4
71
U)
cd
>.,
w
(4.
44 -)
U)
•r4
'-4
0
Cd
-4G)
• ri
-4
4.)
E-
Cd
U)
0
14
p4
U)U
a)
0
Cd
p4
E-
4-i
a)
p
'2)
4)
4.)
U)
Cd
1.0
..4
0
U)
Cl
'2)
•r4
Cd
4.)
•rI
U)
-
U)
.
'2)
u
Cd
1-4r-4
Cd
ci
E
'2)
0
9 to
a)
E-
v.
E
a)
U)
:2
0
a)
'2)0
00
E
•ri
•
bb
l-4
•
4
•ri
,
U)
•H
04-)
1.4 -r-4
4)
4-
4-'
0
0
I-i
C)
01-4
0
1-i
0
Cd
in
1-
0 ?
'-4
()
0
4)
4-t
41
C.)
P4
C.)
0
b'2
?
.-4
4)
•.-1
1-i
r
C.)
• ,-I
•
rl
)<
a)
+-
a)
0 ?
C)
•
Z
U
'2)
1-U
0
41
4-' ?
(1)
i
-
>.- ?
•ri
o
Z
1-U
I-I
U
Biological Sciences 301
?
March 1973
-1.
?
BIOCHEMISTRY I COURSE OUTLINE
CALENDAR DESCRIPTION:
A brief introduction to the structure and function of protein and enzyme
molecules; elementary enzyme kinetics; intermediary metabolism with emphasis
on the three
energy-transducting
systems in animals and plants; niicrosomal
electron transport and its biological implications.
LECTURE #
?
PART I - LECTURE TOPICS FOR BIOSCIENCE 301 - BIOCHEMISTRY I
Introduction:
Physical and chemical laws of life processes;
inanimate vs. living matter. Molecular logic of the living
state.
?
2- 5 ?
Structure and Function
of
Protein Molecules:
Primary, secondary,
tertiary, quaternary conformation, and forces accounting for the
structures. ct-helix: structure and function of myoglobin and
haemoglobin. Variation of amino acid sequences among homologous
functional proteins (myoglobins, cytochromes c) and evolution.
Abnormal a.a. variations in haemoglobin (Sickle Cell Anaemia,
Methaemoglobinemia). Structural proteins: keratin (a-helix),
silk (0-sheet), collagen (triple helix). Proteins and
nutrition.
Denaturation.
?
6-10
?
Enzymes:
Reaction rates and energy of activation; specificity,
active site, allosteric sites and allosteric effectors, substrate-,
product-, feedback inhibition and activation, and their role in
metabolic control; classification and nomenclature (old and new);
cofactors, prosthetic groups, co-enzymes, activators; enzyme
assaying and purification (Enzyme Unit, E. Concentration, Specific
Activity, Molecular and Catalytic Centre Activity, "Balance Sheet";
Initial Velocity; Substrate Conc.; M.-M.-derivation and special
cases (V = 1/2V; (S)
<<<<
Km); Lineweaver-Burk); inhibition
(competitive, non-competitive); other factors (temperature, pH, etc.).
PART II - LECTURE TOPICS FOR INTERMEDIARY METABOLISM
11 ?
Introduction:
Metabolism; logical sequence (in time and space)
of reactions leading to growth and self-replication
+
LIFE, and
its control. Central metabolic pathways, their evolution and
interrelations; energy-yielding vs. energy requiring reactions;
"high-energy" compounds and universal and central role of ATP.
IWAI
•
?
12-15
?
Glycolyeia:
Glucose sources (glycogenolysis, glucogenesis,
gluconeogenesis), glucose activation, galactosaemia; individual
reactions; most important variation of theme: pyruvic decarboxylase
and ethanol dehydrogenase, and how to minimize formation of "fusel
oils" and thus "accentuated unpleasant effects"; logic of glycolysis;
control; reversal; energetics.
?
16-18 ?
TCA cycle reactions including pyruvate dehydrogenase system; fate
of carbons in cycle.
?
19 ?
Removal of TCA intermediates and anaplerotic reactions.
?
20 ?
Mitochondrial electron transport and total energy balance of
glucose + CO2; malate and glycerol-phosphate shuttles.
?
21 ?
Microsomal el. transport and biol. significance (P-450; induction;
detoxification and metabolism of xenobiotics).
?
22-23 ?
Pentose phosphate shunt reactions, "reducing power" and biosynthesis;
roles of DPN vs. those of TPN. General considerations of
carbohydrate metabolism (central position and role of glucose)
and abnormalities (hyper- and hypo-glycaemia and regulation).
?
24-27
?
Lipid Metabolism:
Types of lipids; significance of triglycerides
in energy storage; s-oxidation (including role of carnitine);
. ?
energetics; glyoxylate shunt and significance; fatty acid synthesis;
body fat and nutrition; polyphagia; cachexia; hypercholesterolemia;
alcohol and fatty liver.
?
28-31 ?
Protein Metabolism:
Dynamics of protein metabolism; nitrogen
balance; essential vs. non-essential amino acids; reactions
involving c*-amino-N; role and mode of pyridoxal phosphate;
decarboxylations and biogenic amines; glucogenic vs. ketogenic
a.a.'s. Nitrogen excretion (animonotelic, ureotelic, uricotelic
organisms) with emphasis on urea cycle.
?
32 ?
Integration of carbohydrate, lipid, and protein metabolism and
biochemical universals.
?
33-34 ?
Reguiation and Control:
Cell level: membranes, endoplasinic
reticulum, compartñientation, non-aqueous micelles. Chemical
equilibria; regulatory enzymes; repression and induction.
Organism level: hormonal system, nervous system, differentiation.
?
35
?
Biochemistry and Diseases:
The molecular bases for diseases
("orthomolecular medicine") with several examples for reactions
covered in the course.
Form C-7
SIMON FRASER UNIVERSITY
?
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I
CALENDAR INFORMATION
Program: Biochemistry'
Sub-title or Description:
Course Number: 311 Title:
Analytical Biochemistry
Laboratory
The biochemical analysis of amino acids, peptides, carbohydrates, lipids,
nucleotides, and nucleic acids.
Credit Hours: 2
?
Vector Description: (0-0-4)
Pre-requisite(s): Chemistry 256-2, Biochemistry 301-3 will ordinarily be
taken ncurrently but may precede BICH 311-2.
II
?
?
.ENROLMENT AND SCHEDULING
-.: Estimated Enrolment: 20
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Fall
When course will first be offered: 74-3
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University?
Companion course to Biochemistry 301. By dropping Chemistry 426 no course
content overlap will exist in the Chemistry Department. There is some
overlap with experiments in Bio-Science 428 and 438.
B.
What is the rarge of 'topics that may be dealt with in the course?
cf. course outline attached.
C.
How does this course fit the goals of the program?
It is of fundamental importance to the Biochemistry Program.
D.
How does
this course
affect
degree requirements?
It is a core requirement of the Biochemistry Program.
2...
Page 2
S
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
description on
p.
245 and
p.
260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
HEM 426.
G.
What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Bio-Science and Kinesiology majors may
wish,to take this course as an elective.
H.
Other reasons for introducing the course.
N/A
IV BUDGETARY AND SPACE FACTORS
. ?
A. Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by Departments
of the Faculty of Science and approved by the Chairman of the Biochemistry
Committee.
B.
What are the special space and/or equipment requirements for this course?
Laboratory space is available in C9014, and most of the equipment is
currently available.
C.
Any other budgetary implications of mounting this course:
None
APPROVAL -.Faculty Curriculum
Faculty:
Senate:
0
S
COURSE OUTLINE
BICH 311-2
?
Analytical Biochemistry Laboratory
No. of Labs
?
Experiments
4 ?
Amino acids and peptides: titration of unknown
amino acid; sequence determination of a dipeptide
and analysis by paper chromatography; demonstration
of the use of the amino acid sequencer.
3 ?
Carbohydrates: acid and enzymatic hydrolysis of
polysaccharides and spectrophotometric assay;
structure determination of a disaccharide by
borohydride reduction and analysis by paper
chromatography; mutarotation and other carbohydrate
chemical tests.
2 ?
Lipids: isolation and separation of phospholipids,
neutral fats and steroids from various tissues and
analysis by thin-layer or silica gel column chro-
matography.
4
?
Nucleic acids: isolation of DNA from E. ccli; DNA
and RNA assays; determination of base ratios of
RNA.
.
I ?
CALENDAR INFORMATION
Program: Biochemistry
Sub-title or Description:
Course Number: 312 Title:
Metabolism Laboratory
Form C-7
.
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
Experiments demonstrating the major energy yielding processes of metabolism
and selected biosyntheses.
Credit Hours: 2
?
Vector Description: (0-0-4)
Pre-requisite(s): Chemistry 256-2, Biochemistry 302-3 will ordinarily be
taken conctirrnt1y but may precede BICH 312-2.
II ?
ENROLMENT AND SCHEDULING
• ?
Estimated Enrolment: 20
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Spring
When course will first be offered: 75-1
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University?
Companion course to Biochemistry 302. By dropping Chemistry 426 and 427 no
course content overlap will exist in any department.
B.
What is the range of topics that may be dealt with in the course?
cf. course outline attached.
C.
How does this course fit the goals of the program?
It is of fundamental importance to the Biochemistry Program.
D. ?
How does
this course
affect
degree requirements?
It-is--a
care
requirement
of the
Biochemistry Program.
2...
.
.
Page 2
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and p. 260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
CHEM 427.
C. What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Blo-Science and Kinesiology majors may
wish to take this course as an elective.
H. Other reasons. for introducing the course.
N/A
IV BUDGETARY AND SPACE FACTORS
A.
Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by Departments
of the Faculty of Science and approved by the Chairman of the Biochemistry
Committee.
B.
What are the special space and/oT equipment requirements for this course?
Laboratory space is available in C9014. Some new equipment will be
required, e.g. spectrophotometer and respiration apparatus.
C.
Any other budgetary implications of mounting this course:
" .i $10,000
APPROVAL - Faculty Curricililum
Committee
?"^
Faculty: ?
.
Senate:
I
0
.
COURSE OUTLINE
BICH 312-2
?
Metabolism Laboratory
No. of Labs
?
Experiments
2 Glycolysis Experiment: demonstration of pyruvate
and acetaldehyde formation in yeast by a trapping
experiment; the effect of inhibitors of glycolysis.
3 ?
Oxygen uptake experiments: studies with a Warburg
apparatus or oxygen electrode with yeast, E. coli,
and isolated mitochondria in the presence of various
substrates and inhibitors of the citric acid cycle.
3
?
Electron transport experiments: spectrophotometric
assays of NAOR oxidation, cytochrome reduction
and oxidative phosphorylation in isolated mito-
chondria; the effect of inhibitors of electron
transport and uncouplers.
. ?
3 ?
Photosynthesis experiments: demonstration of Hill
reaction (dye reduction and oxygen evolution)
and photophosphorylation in isolated chioroplasts;
comparison with bacterial chromatophores; the
effect of inhibitors or herbicides.
Biosynthesis of ergosterol: incorporation of
radioactive acetate into
-
and isolation of labeled
ergosterol from yeast.
0
BE
Form C-7
.?
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I ?
CALENDAR INFORMATION
Program: Biochemistry
?
Course Number: 403 Title:
Physical Biochemistry
Sub-title or Description:
The physical properties of biopolymers and their use in molecular weight and
structure determinations; modern methods of purification of proteins and
nucleic acids; properties of membranes and methods of membrane analysis and
study.
Credit Hours: 3
?
Vector Description: (3-1-0)
Pre-requisite(s): Physics 102-3 @r Physics 202-2 and 204-a, Math 253-4 and
Biochemistry 301-3. Biochemistry 413-2 will ordinarily be
taken concurrently, but may be taken subsequent to BICH 403-3.
II ?
ENROLMENT AND SCHEDULING
Estimated Enrolment: 10
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Spring
When course will first be offered: 75-1
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University?
There is no overlap with any other course in any department.
B.
What is the range of topics that may be dealt with in the course?
cf. course outline attached.
C.
How does this course fit the goals of the program?
It is offundamental importance to the Biochemistry Program.
D.
How does this course affect degree requirements?
It is a core requirement of the biochemistry Program.
Page 2
S ?
1
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
description on
p.
245 and
p.
260.
F.
What course, if any, is being dropped from the calendar if this
course is approved?
None.
G.
What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Bio-Science and Kinesiology majors may
wish to take this course as an elective.
H.
Other reasons for introducing the course.
This course represents an important area in modern biochemistry which has
not been treated at all in the current course offerings.
IV BUDGETARY AND SPACE FACTORS
5 ?
A. Which faculty will be available to teach this course?
A new faculty member will be required for which a position has already been
budgeted and a search is in progress in the Chemistry Department.
B.
What are the special space and/or equipment requirements for this course?
None.
C.
Any other budgetary implications of mounting this course?
None.
APPROVAL - Faculty Curriculum Coittee:
Faculty:
Senate:
0
COURSE OUTLINE
BICH 403-3
?
Physical BiOchemIstry
No. of Lect. ?
Topic
Introduction and Review of Bi
?
ers- -Their
review of the major types of biopolymers and
their physical properties; how X-ray diffraction
has been used to determine tertiary structure;
electron microscopy; quaternary structure,
aggregation and disaggregation; denaturation;
solubility; crystallization; salting out; density;
dipole moments.
Colligative Properties: Osmotic pressure and
osmosis; the effect of solutes on vapor pressure,
bôdiling and freezing points; Donnan equilibrium.
6 ?
Optical Properties: Refraction, birefringence,
optical rotation, ORD, CD, light scattering,
NMR, ESR, UV, visible, IR, Raman, dichroism,
fluorescence and polarization of fluorescence.
6 ?
Surface Properties and Membranes: Surfaces and
fnterfaces; adsorption chromatography; affinity
chromatography; monolayers and films; membrane
structure; detergent action on membranes;
isolation of multienzyme complexes from membranes
(e.g. mitochondria, ER, and chioroplasts).
6 ?
Ordinary Transport Properties: A review of flow
processes in solution; viscosity; diffusion;
Schlieren optical system; diffusion in gels and
gel filtration; diffusion through membranes and
dialysis; flow birefringence; dielectric
dispersion; electric birefringence; and depolar-
ization of fluorescence.
5 ?
Ionic and Electrokinetic Properties: Biopolymers
as polyions; conductance; membrane potentials;
active transport; ion-exchange chromatography;
.
Course Outline
BICH 403-3
Page 2
No. of Lect. ?
Topic
electrophoresis; electrofocusing, pH and density
gradient electrophoresis; detergent-gel electro-
phoresis; immunoelectrophoresis.
3 ?
S
Sedementation Properties: Sedementation in the
ultracentrifuge; sedementation velocity and
optical measurements; approach to equilibrium
and zonal and density gradient centrifugation.
0
Form C-7
. ?
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
CALENDAR INFORMATION
Program: Biochemistry ?
Course Number: 411 Title:
Enzymology Laboratory
Sub-title or Description:
Experiments on enzyme kinetics, enzyme activation, and inhibition.
Credit Hours: 2
?
Vector Description: (0-0-4)
Pre-requisite(s): Biochemistry 311-2 or 312-2, Bio-Science 401-3 will
ordinarily be taken concurrently but may precede
BICH 411-2.
II ?
ENROLMENT AND SCHEDULING
Estimated Enrolment: 10
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Fall
When course will first be offered: 75-3
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar cources in the same department
and from courses in other departments in the University?
Companion course to Bio-Science 401-3. By droppingChemistry 427, no course
content overlap will exist in any department.
B.
What is the range of topics that may be dealt with in the course?
cf. course outline attached.
C.
How does this course fit the goals of the program?
It is of fundamental importance to the Biochemistry Program.
D.
How does this course affect degree requirements?
It is a core requirement of the Biochemistry Program.
2...
Page 2
B. What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and p. 260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
None.
G.
What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Bio-Science and Kinesiology majors may
wish to take this course as an elective.
H.
Other reasons for introducing the course.
N/A
IV BUDGETARY AND SPACE FACTORS
•
?
A. Which faculty will be available to teach thiscourse?
Members of the Biochemistry Committee, and any others seconded by Departments
of the Faculty of Science and approved by the Chairman of the Biochemistry
Committee.
B.
What are the special space and/or equipment requirements for this course?
Laboratory space is available in C9014. Some new equipment will be required,
e.g. a temperature jump apparatus.
C.
Any other budgetary implications of mounting this course?
$5,000
APPROVAL - Faculty Curriculum
Faculty:
Senate:
S
COURSE OUTLINE
BICH 411-2
?
Enzymology Laboratory
No. of Labs
?
Experiments
6 ?
Enzyme kinetics (normal saturation): kinetic
assays and protein determination, pH optimum,
activation energy, K , and inhibition (competitive
and non-competitive)
mof
-ga1actosidase.
5 ?
Enzyme kinetics (sigmoidal): Determination of
Hill parameters; demonstration of positive and
negative effectors for e.g. phosphofructo kinase
or glutamine synthetase.
2 ?
Temperature-Jump/Relaxation experiment or Demon-
stration of induction of lactose metabolism in
E. coli.
.
0
Form C-7
C
?
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I ?
CALENDAR INFORMATION
Program: Biochemistry ?
Course Number: 413 Title:
Physical Biochemistry Laboratory
Sub-title or Description:
Enzyme isolation and purification; the measurement of physical properties of
macromolecules; studies with bio-membranes.
Credit Hours: 2
?
?
Vector Description: (0-0-4)
Pre-requisite(s): Biochemistry 411-2, Biochemistry 403-3 will ordinarily
'be taken concurrently, but may precede BICH 413-2.
II
ENROLMENT AND SCHEDULING
. ?
Estimated Enrolment: 10
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, every Spring
When course will first be offered: 76-1
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department and
from courses in other departments in the University?
Companion couse to Biochemistry 403. By dropping Chemistry 427, no course
content overlap' will exist in any department.
B.
What is the range of topics that may be dealt with in the course?
cf. course outline attached.
C.
How does this course fit the goals of the program?
It is of fundamental importance to the Biochemistry Program.
D.
How does this course affect degree requirements?
It is a core requirement of the Biochemistry Program.
2...
Page 2
.
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and
p.
260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
None.
G.
What is the nature of student demand for this course?
There are approximately 80 students currently registered in the Biochemistry
Program. In addition, Chemistry, Bio-Sciences and Kinesiology majors may
wish to take this course as an elective.
H.
Other reasons for introducing this course
The majority of the experiments deal with important techniques in modern
biochemistry which have not been employed in current course offerings.
IV BUDGETARY AND SPACE FACTORS
SA. Which faculty will be available to teach this course?
A new faculty member will be required for which a position has already
been budgeted and a search is in progress in the Chemistry Department.
B.
What are the special space and/or equipment requirements for this
course?
Laboratory space is available in C9014. Quite a bit of new equipment will
be required as this course represents a new subject area.
C.
Any other budgetary implications of mounting this course
Not Known
I
APPROVAL - Faculty Curriculum Committee,f'''
Faculty:
Senate:
0
S
COURSE OUTLINE
BICH 413-2 ?
Physical Biochemistry Laboratory
.
No. ?
of Labs
Experiment
7
Isolation of an Enzyme:
?
This may be an enzyme of
the student's own choice;
?
to involve: ?
a)
?
salting
out and crystallization; b) purification by dialysis
and chromatography (e.g.
?
Sephadex, ?
ion-exchange,
adsorption etc.); c) enzyme assay and study of
denaturation or disaggregation; d) analysis of
purity by electrophoresis or ultracentrifugation.
1
Osmotic Pressure Experiment;
?
With a given protein.
2
Optical Methods Exeriment: ?
Determination of
helix-coil transition of a protein or "melting
point" of,a nucleic acid by a suitable method
(e.g. ?
ORD, ?
CD or spectroscopy).
2
Membrane Dissolution Experiment: ?
Dissolution of
mitochondrial membrane with detergents and isolation
of an enzyme complex or separation of membrane
proteins by detergent-gel electrophoresis.
1
•Viscosity
or Diffusion Experiment:
?
With a given
protein.
0
Form C-7
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I
?
CALENDAR INFORMATION
Program: Biochemistry ?
Course Number: 420 Title:
Selected Topics in Contemporary
Biochemistry
Sub-title or Description:
A course of selected topics of contemporary interest to biochemists, such
as a drug research, pollution, cancer research, genetic engineering, aging,
memory research, etc.
Credit Hours: 3
?
Vector Description: (3-1-0)
Pre-requisite(s): Permission of the Biochemistry Committee., Upper levels
standing (at least 60 semester hours) in a Faculty of
Sence degree program will usually be required.
5 ?
II ?
ENROLMENT AND SCHEDULING
Estimated Enrolment: 10-20 (?)
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Yearly, at any semester
When course will first be offered: 75-1 (?)
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University.?
The course will be completely different from any of the current courses.
It deals with many contemporary topics for which there will be no time for
discussion in the core courses.
B.
What is the range of topics that may be dealt with in the course?
cf. sub-title or description above.
C.
How does this course fit the goals of the program?
. ?
It will apply many of the fundamental principles of the core program to
issues of contemporary interest to biochemists and concerned citizens alike.
D.
How does this course affect degree requirements?
It will be available as an elective to majors and honours students in the
upper division of any degree program in the Faculty of Science.
S
Page 2
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new
,
Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and
p.
260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
None.
G.
What is the nature of student demand for this course?
Not known.
H.
Other reasons for introducing the course.
Contemporary issues are often of extreme interest to students but receive
little or no attention in courses. This course will attempt to present
current approaches to these problems to upper division science students,
in order tor try and bridge the gap between theory and practical
application of biochemical principles.
5 ?
IV BUDGETARY AND SPACE FACTORS
A.
Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by
Departments of the Faculty of Science and approved by the Chairman of
the Biochemistry Committee.
B.
What are the special. space and/or equipment requirements for this
course?
None.
C.
Any other budgetary implications of mounting this course?
None.
APPROVAL - Faculty Curriculum Committee'
"
Faculty:
S
Senate:
S
S
Form C-7
.
?
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I ?
CALENDAR INFORMATION
Program: Biochemistry ?
Course Number: 490 Title:
Directed Study in Advanced Topics
of Biochemistry
Sub-title or Description:
Directed reading in a topic chosen in consultation with a supervisor.
Credit Hours: 3
?
Vector Description: None
Pre-requisite(s): Permission of the Biochemistry Committee. Upper levels
standing (with
.
at least 75 semester hours) in the
Biochemistry Program will usually be required.
II ?
ENROLMENT AND SCHEDULING
Estimated Enrolment: Not known.
Semster Offered (e.g. Yearly, every Spring; twice yearly, Fall and Spring):
Available every semester
When course will first be offered: 74-3
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University?
Directed reading course dealing with biochemical topics.
B.
What is the range of topics that may be dealt with in the course?
As decided upon by consultation between the student and a member or members
of the Biochemistry faculty.
C.
How does this course fit the goals of the program?
This course will .provide an opportunity for interested students to thoroughly
pursue an area of interest to them with the individual guidance of a member
or members of the Biochemistry faculty.
r
2...
Page 2
D.
How does this course affect degree requirements?
It will be available as an elective to majors or honours students in their
7th
or later semester, with the permission of the Biochemistry Committee.
E.
What are the calendar changes necessary to reflect the addition of
this course?
Substitution of new Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and
p.
260.
F.
What course, if any, is being dropped from the calendar if this course
is approved?
None.
G.
What
is the
nature of student demand for this course?
Not known.
H.
Other reasons for introducing the course.
N/At
IV BUDGETARY AND SPACE FACTORS
A.
Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by
Departments of the Faculty of Science and approved by the Chairman of
the Biochemistry Committee.
B.
What are the special space and/or equipment requirements for this
course?
None.
C.
Any other budgetary implications of mounting this course?
None.
APPROVAL - Faculty Curriculum Committee
Faculty:
Senate:
.
•1
Form C-7
SIMON FRASER UNIVERSITY
FACULTY OF SCIENCE
NEW COURSE PROPOSAL
I ?
CALENDAR INFORMATION
Program: Biochemistry ?
Course Number: 491 ?
Title:
Undergraduate Research
Sub-title or Description:
Laboratory research for preparation of a thesis for the honors degree
in Biochemistry.
Credit Hours: 5
?
Vector Description: None
Pre-requisite(s): Permission of the Biochemistry Committee.
II ENROLMENT AND SCHEDULING
5 ?
Estimated Enrolment: Not known.
Semester Offered (e.g. Yearly, every Spring; twice yearly, Fall and
Spring):
Available every semester.
When course will first be offered: 74-3
III JUSTIFICATION
A.
What is the detailed description of the course including differentiation
from lower level courses, from similar courses in the same department
and from courses in other departments in the University?
Research course dealing with biochemical topics.
B.
What is the range of topics that may be dealt with in the course?
As decided upon by consultation between the student and a member or
members of the Biochemistry faculty.
C.
How does this course fit the goals of the program?
This course will provide an opportunity for interested students to
is ?
member an area of research in biochemistry under the guidance of a
member or members of the Biochemistry faculty. It is of fundamental
importance for honours students in the degree program.
Page 2
D.
How does this course affect degree requirements?
It is required of honours students, and will be available to majors
students in their 7th or later semester, with the permission of the
Biochemistry Committee.
B. What are the calendar changes necessary to reflect the addition
of this course?
Substitution of new Biochemistry Program (cf. attached) for current
descriptions on
p.
245 and p. 260.
F.
What course, if any, is being dropped to reflect the addition of
this course?
None.
G.
What is the nature of student demand for this course?
Not known.
H.
Other reasons for introducing the course.
.
IV BUDGETARY
AND
SPACE FACTORS ?
N/A
A.
Which faculty will be available to teach this course?
Members of the Biochemistry Committee, and any others seconded by
Departments of the Faculty of Science and approved
by the Chairman
of the Biochemistry Committee.
B.
What are the special space and/or equipment requirements for
this course?
The research equipment of the faculty member or members involved will
be employed by the student.
C.
Any
other budgetary implications of
mounting this course?
Support to the faculty member(s) involved for the purchase of special
chemicals and equipment will amount to approximately $200 per student.
APPROVAL -
Faculty Curriculum Committee
0-'f'"
Faculty:
< Z7
";4^
Senate:
S
.
io
PART ?
II
CHANGEOVER PROCEDURES
and
FREQUENCY OF COURSE OFFERINGS
.
0
BIOCHEMISTRY PROGRAM
A. Changeover from Old to New Program
Students who have declared a Majors or Honors degree program
in Biochemistry or who will do so up to and including the
Summer Semester, 1974, may either complete the program as
outlined in the 1973-74 Calendar or make the changeover from
the old to the new program as outl
—
ined below, whichever is
most convenient. Students declaring a Majors or Honors
degree program in Biochemistry during or after the Fall
Semester, 1974, must follow the new degree program.
I. Majors Students
1.
Courses unaffected. The following courses are
required by both programs: Bio-Science 1014*,
102_4*, 202-3
3%
401-3 and 402-3; Chemistry 104-3,
105-3, 115-2, 117-2, 251-3, 252-3, 256-2, 261-3, and
356-2; Mathematics 151-3, 152-3, and 253-4; Physics
[1
?
101-3 and 102-3 (or 201-2, 202-2, and 204-2).
2.
Courses requiring equivalents. The following
courses or combinations of courses will be considered
equivalent. If for some reason it is impossible to
obtain any of these combinations see the Biochemistry
faculty for counselling. You may take:
EITHER
CHEM 232-3
CHEM 421-3 and 422-3
CHEM 426-2 and 427-2
One of BISC 428-3, 438-3,
or ?
8-3
OR
CHEM 233-2
BICH 301-3 and 302-3
BICH 311-2 and 312-2
BICH 411-2 and 413-2
3.
Courses no longer required. The following courses
will no longer be required. You may, of course,
use them as electives: Bio-Science 201-3, 303-3,
305-3, and 315-3; Chemistry 457-3; Mathematics 352-2.
4.
New course requirements. The following courses
represent new requirements: Biochemistry 403-3 and
Bio-Science 302-3.
0 ?
*These courses are strongly recommended in the new program.
.
.
II. Honors Students
Honors students will follow the procedures as outlined
for Majors students above with the following additions:
1.
Courses requiring equivalents. You may take either
Biochemistry 491-5 or one of Chemistry 481-5 or
Bio-Science 498-3.
2.
Courses no longer required. The following courses
wilIl no longer be required. You may, of course,
use them as electives: Bio-Science 455-3 and 481-3;
two of Chemistry 341-3, 351-3, 361-3; Physics 202-2
(if not taken in the Core), 206-2, and 233-2.
B. Frequency of Course Offerings
The following schedule will be maintained during the first
two years of operation of the new Biochemistry Program.
Subsequent years will follow the 1975-76 schedule.
Fall, 1974
?
Spring 1975
BTCH 301-3
?
BTCF[ 362-3
BICH 311-2
?
BICH 312-2
BICH 403-3
Fall, 1975
?
Spring, 1976
BICH 301-3
?
BICH 302-3
BICH 311-2
?
BICH 312-2
BICH 411-2
?
BICH 403-3
BICH 413-2
Note: Biochemistry 490-3 and 491-5 will be available during
all semesters. Biochemistry 420-3 will be available
at least once a year.
L
r
PART ?
III
ADMINISTRATIVE STRUCTURE
of the
BIOCHEMISTRY CURRICULUM COMMITTEE
S
L
-I
FACULTY OF SCIENCE BIOCHEMISTRY COMMITTEE
.
J. S. Barlow
S. Aronoff
A.H. Burr
I. Glen
G.R. Lister
P. Oloffs
J.E. Rahe
A.C. Oehlschlager
W.R. Richards
K.N. Slessor
A.M. Unrau
N.M.G. Bhakthan
A.J. Davison
R. Hallett
A. Koat
Associate Dean of Science
Chairman
Dean of Science
Biological Sciences
Biological Sciences
Biological Sciences
Biological Sciences
Biological Sciences
Chemistry
Chemistry
Chemistry
Chemistry
Kines iology
Kinesiology
Undergraduate Student
Undergraduate Student
0
1
% '
BIOCHEMISTRY CURRICULUM COMMITTEE
40
?
As passed by the Faculty of
*
Science at its meeting of March 21, 1972.
I. Establishment of Committee
1.
The Dean shall establish a Biochemistry Curriculum
Committee consisting of all those members of the Faculty
whose regular teaching responsibilities would or could
include a course within the
Biochemistry
curricula (i.e.,
not including service courses for the Program, as provided
by the several Departments), plus two students majoring
in Biochemistry and at least one of whom must be an
undergraduate. By consent of the majority of the Committee,
and with the approval of the Dean, members of Simon Fraser
University outside the Faculty of Science whose regular
teaching responsibilities would or could be included in
the
Biochemistry
curricula may also become members of
this Committee. The composition shall be reviewed and,
if necessary, altered by the Dean, at periods not to
exceed three years and no more frequent than one.
2. Within this Curriculum Committee there shall be established
by the Dean, with the approval of the Committee, an
• ?
Executive Panel whose membership shall consist of four
members of the Faculty of Science, each of whose
major
teaching responsibilities lie in the discipline of
Biochemistry, plus two students majoring in Biochemistry
and at least one of whom shall be an undergraduate. In
addition, there will be a Chairman of this Panel,
appointed by the Dean, who will also be the Chairman of
the Committee.
3. The Executive Panel shall have the following responsibilities:
a. To report to the Faculty of Science on behalf of
the Biochemistry Curriculum Committee.
b. To consider and bring forward reports on policy
matters to the Faculty of Science as appropriate.
c. To recommend on behalf of the Biochemistry Curriculum
Committee to the Faculty of Science courses for
approval, candidates for degrees, scholarships and
awards, and other such matters when empowered to do
so by the Faculty of Science.
d. To act for the Biochemistry Curriculum Committee
in all matters specified in this document in
. ?
circumstances where a full meeting of the Committee
is not possible. Any actions taken in this way
shall be subject to ratification by the Faculty of
Science.
-2-
S
4.
The Dean of Science shall be a member
ex-officio
of
the Executive Panel.
S. The Quorum for a meeting of the Curriculum Committee
shall be half of its membership; and of the Executive
Panel, the Chairman, 2 additional Faculty members and
1 student member.
II. Responsibilities of the Committee
1.
It shall be a responsibility of the Curriculum Committee
to develop an undergraduate curriculum in Biochemistry,
and, if desirable, a graduate and professional one. The
Biochemistry Committee shall establish no course beyond
its immediate discipline. It shall seek to interdigitate
its curriculum with those of existing Departments and
shall depend upon them for service curricula. The
Committee reports to the Faculty on matters of curricula.
2.
The Committee will have the responsibility for all normal,
non-budgetary matters relating to instruction, e.g.
counseling and evaluation of students, developing seminars,
short courses, lecture series, etc.
III. Relation of the Committee to Existing Departments
1.
Faculty members of the Curriculum Committee will be members
of existing Departments, or equivalent administrative
units, without prejudice. New faculty will be appointed
by a
Dppartment
and seconded to the Committee for
instructional purposes in whole or in part. The Department
will be responsible for all administrative matters
relating to a Faculty committee member, including tenure,
promotion, contract renewal, and salary. Further, the
Chairman of the Curriciilum Committee shall provide
annually at the appropriate time, or at other times upon
request, to the Chairman of the Faculty member's Department,
such evaluations and recommendations as the Department
Chairman may require with regard to instructional performance
and related matters.
2.
All research matters of the Faculty member will be the
responsibility of his Department.
3.
It will be the responsibility of the Faculty member's
Department to assist him in budgetary matters relating to
•
?
instruction, e.g. the assignment of T.A.'s, purchase
of instructional equipment, allocation of teahing space,
etc.
-3-
