"That Senate approve, as set forth in 

the new course proposal for 

Inorganic Chemistry of Biological Processes." 

.

Chem 

..

str . y 

.  ... 233-2 .... ...... 

.... 

June 18, 1974 

At its meeting of 4th June, 1974, the Senate 

Committee on Undergraduate Studies considered the attached 

new course proposal for Chemistry 233-2 and recommends its 

approval by Senate. 

The documentation provided includes the 

memorandum of transmittal to SCUS from the Faculty of Science, 

the course proposal form and the course description. It should 

be noted that, while this course will become part of the core 

program in Bio-Chemistry (see section 3 of course proposal 

form and P.1 of Bio-Chemistry proposal), it has been submitted 

separately from that proposal since it is a purely departmental 

course which has followed a different route to Senate from the 

revisions in that program. 

I. Mu ridge 

ains 

att. 

Senate Cominitteen     

.

Undergat..u4..S   

.

Sub ? 

. NE1 

C//Fr'/f77'Y .23?-2 

The Faculty of Science at its meeting of April 9, 1974 approved 

the attached new course proposal for Chemistry 233-2, Inorganic 

Chemistry of Biological Processes and recommends its approval 

by SCUS. 

1w

cc: T. Bell, Chairman 

Department of Chemistry 

. ?

...

SENATE COMMITTEE ON UNDERGRADUATE STUDIES? 

NEW COURSE PR01OSAL FORM 

1. Calender Information 

?

Department: ? 

Chemistry 

Abbreviation Code: 

Chem 

Course Number: 

233

- Credit Hours; 

2

Vector: 

-

2-1-0 

Title of Course: 

?

Inorganic Chemistry of Biological Processes 

Calendar Description of Course: 

An introduction to the principles governing the formation, 

properties, and investigation of metal-ligand complexes with 

special reference to the role of metals in biological processes. 

Nature of Course 

Lecture 

Prerequisites (or special instructions): 

Chemistry 

105-3. 

It is recommended that Chem 

251

precede or 

be taken concurrently. 

What course (courses), if any, is being dropped from the calendar if this course is 

approved: 

None. The frequency, of offering of Chem 

232

will be reduced 

if demand necessitates. 

2. Scheduling 

How frequently will 

the course be offered? 

Once per year initially 

Semester in which the course will first be offered? 

?

Fall 

1975

. ?

Which of your present faculty would be available to make the proposed offering 

possible? Profs. Sutton, Einstein, Peterson 

3, Objectives of the Course 

This is a core course in the biochemistry majors program; 

designed to provide instruction in a sub-area of inorganic 

chemistry of importance and applicability to biochemistry. 

4.

Requirements 

tary and Space 

(for information only) 

What additional resources will be required in the following- areas: 

Faculty 

?

Nil (Rearrangement of the Chemistry program offerings 

Staff ? 

'

Nil will permit CHEM 233 to be offered once per year 

with existing faculty.) 

Library 

?

Nil

Audio Visual 

Nil

Space 

?

Lecture Room 

Equipment ? 

Nil

5.

Approval 

Date: 

Depar tmcnt)iu irman 

?

Dean' ? 

Chairman, SCUS 

(When co:pleting this form, for instructions see Memorandum SCUS 73•-34a. 

Attach coure outline). 

Chemistry 

233-2 

Inorganic Chemistry of Biological Processes 

Course Description 

Lecture 

?

Background: main biological functions of metal ions; 

oxidation states and electronic configurations of metal 

ions; size relationships, salvation energies, entropies 

and structure; complex formation, stability constants, 

types of ligand, chelates. 

?

5-10 ? 

Group I and II ions Na, K, Mg and Ca: general properties; 

distribution inside and outside cells; concentration 

gradients, membrane selectivity and electrical potentials. 

Selectivity of macrocyclic ligands (including antibiotics 

and phosphoprotein) toward metal ions. The sodium and 

calcium pumps. Trigger and control mechanisms utilising 

Ca

2

, muscle contraction and nerve-impulse transmission. 

?

11-1k ? 

First-Row Transition-Metals M 

2 and M 3 

ions and their 

. ?

general properties. Ligand field theory; high-spin/low- 

spin complexes, visible spectra, octahedral and tetrahedral 

complexes. Distortions from regular geometry, unusual 

coordination numbers. Ligand-field stabilisation effects. 

?

15-2 

4 ?

Metal-.Activated Enzymes Metalloenzymes and metal-protein 

complexes, general description and distinction. Metal- 

binding sites, metal ion probes. Models for binding sites. 

Hydrolytic metal-activated enzymes (carboxypeptidase-A 

as detailed exam 

p

le). Oxidation-Reduction metalloproteins, 

electron-transport, heme and non-heme iron proteins, copper 

proteins, cobalt B 

12

coenzymes. Nitrogen fixation and 

the nitrogen cycle. Oxygen carrier and storage metallo- 

proteins, model for hemoglobin, synthetic oxygen carriers. 

Student Text-Book• 

None currently available specific to the course as a whole. Lectures 

and 11-14, together with parts of 

15-24 

are covered by Huheey, 

"Inorganic Chemistry 

Teachers Text-Book 

M.N. Hughes, The Inorganic Chemistry of Biological Processes". 