Page 1
Page 2
Page 3
Page 4
Page 5
Page 6
Page 7
Page 8
Page 9
Page 10
Page 11
Page 12

(Formerly S.74-51) 

MEMORANDUM

I

?

SENATE 

?

From ?

SENATE COMMITTEE ON 

UN1WT'RAfl11ATF

STUDIES 

Subject

_NEW 

COURSE PROPOSAL - 

?

Date MAY 17,

1974

- CLINICAL CHEMISTRY 

MOTION 1: ? 

"That Senate approve, as set forth in S.74-73, 

the new course proposal for CHEM 420-3 - 

Clinical Chemistry - to be offered once and 

to be further evaluated before subsequent 

offering." 

MOTION 2: ? 

"That Senate waive the normal two semester 

time lag requirement in order that CHEM 420-3 

may be first offered in the Fall semester 74-3." 

Note: 

?

At its meeting of May 6, 1974, Senate passed the 

following motion: 

"That Paper S.74-51 be referred to the Kinesiology 

Department for comment." 

.

SiMON FRASER UNIVERSITY

5.747

MEMORANDUM

........... ... Dr. Bell                                

From.. ?

Dr. E. W. Banister 

. ?

.

Chemistry Department 

?

Chairman, Kinesiology Department 

Subject.. Proposed Chem 420-Clinical Chemistry 

?

Date ? 

May 16, 1974. 

Thank you for your memo of May 7, 1974 received in this office May 10th, 

1974 with regard to the above course. 

Dr. Davison met with Dr. Rockerbee and Ochschlager to discuss the course 

and the extent of its overlap or possible integration with Kinesiology courses. 

The general desirability of offering this kind of course on campus is I 

think unquestioned, representing a way in which the university can engineer 

unique liasion with, and academic opportunities for professionals in the 

general health care field (such as the Association of Clinical Chemists), 

which do not duplicate existing programs in other B.C. universities. 

It is my opinion that in light of the discussion of Dr. Davison with Drs. 

Rockerbee and Ochschlager that the supervision of content and teaching of 

• ? 

material within this course and the general long-term aim of developing a 

coherent program in clinical chemistry would be better served through an 

interdisciplinary approach with representation from biochemists, Kinesiologists 

and chemists rather than from a narrow base of jurisiction entirely within 

chemistry. 

Let me illustrate the issue from a couple of items from the overwhelming' 

range of topics presented for consideration in the course itself (Clinical 

Chem. 420). 

Item 5 

?

Respiratory function and biochemical acid-base balance. 

This topic for full understanding implies a thorough knowledge of 

respiratory mechanics together with complex inter-relationship of the cardio 

respiratory systems as they relate to both volatile and non-volatile acid 

transport and elimination in the body. It may be possible to become familiar 

with the functional anatomy and interrelationships of these systems incident- 

ally during the course of the chemical considerations, but I doubt it, espec- 

ially as the pre-requisites for the course include no human physiology course. 

Items 22 and 23 Diagnostic enzymology 

Cardiac enzyme disturbances and their diagnostic implications 

Discussion of diagnostic or clinical implications of enzymes and isoenzymes 

implies an ability to recognize the significance of the appearance of these 

enzymes in abnormal proportions In the serum regarding the cellular structures 

from whence they must have "leaked'. There seem to be no requirement, before 

Cont'd... 

.

Page 2 

taking the course (pre-requisites) for any fine structural, cardio-vascular 

or muscle mechanics as they pertain to heart structure and function. 

There are definite points of overlap with Kines. 330 (human energy meta- 

bolism) Kines. 405 (Human Physiology i), Kines. 406 (Human Physiol. ii), 

Kines 326 (Gross Anatomy), Kines. 336 (Microscopic anatomy) and certain courses 

within the proposed program of M.Sc. Rehabilitation Science, i.e. Kines. 455 

(Lab Diagnostic Techniques) and 

851

(Histopathology). To the extent that 

points of overlap represent reinforcement of material taught in both courses 

this is not undersirable. To the extent that certain items essential to full 

understanding of material taught in one course are assumed to be known or 

chosen to be omitted, this compromizes the learning situation. 

My remarks are directed mainly at the long-term consideration of further 

offerings of this course or associated courses into a program of clinical 

chemistry and my department has no objections to flying this course as a 

barometer of interest; we would however have decided reservations about the 

continued development of a program except on an interdisciplinary basis 

within or without the Faculty of Science. 

Sincerely yours, 

• ? . ? 

-.

2 ?

••-.

Dr. E. W. Banister 

Professor and Chairman 

EWB/gw 

cc: ? 

Dr.

R.

Brown 

Dr.

S.

Aronoff 

Dr.

K.

Strand 

Dr.

A.

Oehlschlager 

Mr.

H. Evans / 

SIMON

To ?

Dr. E. Banister 

Chairman, Kinesiology 

Subject............

Proposed 

Chem I20, Cl: 

Chemis try 

FRASER UNIVERSITY

MEMORANDUM

From ... ... ....

T.N. Boll, Chairman 

Dept ? 

Department of Chemistry 

Date ? 

May

1

7, 197k 

Thank you for your memo of May 16th on the above subject. 

The operative concern at this 

chemistry course, Chem 420 - Ci 

approved by Senate, and in this 

paragraph of your memo applies. 

Department has no objections to 

a barometer of interest. 

moment is whether a single 

inical Chemistry, should be 

regard I believe the last 

That is, the Kinesiology 

our trying this course as 

We are currently attempting to assess whether a program in 

Clinical Chemistry would be a useful thing to pursue, and 

what might constitute the contents of a useful program. 

These 

Co

nsiderations are at present in the very early stages 

and I well recognize that there may be requireIn 

?

,

. ?

a program which lie in other areas of the university, 

en for 

just 

such 

as a chemistry program requires physics and mathematics 

Please rest assurred there will be ample opportunity for 

discussions with the Kinesiologists at the various stages 

of the program 

dev

elopment should the department pursue 

further the development of clinical chemistry. 

. N. Bell 

cc: H. Evans 

S. Aronoff 

From. ?

1'. N. Bell, Chairman 

Chemistry Department 

Date ....

............. may

SiMON FRASER UNIVERSITY

Adlk

MEMORANDUM

Please find attached a copy of a memo to Dr. E. Banister 

from myself. I believe the question implied by the Senate 

in its referral of the proposed course, Chain 420, to the 

Kinesiology Department ,has now been answered. 

I will be most grateful if you can ensure that the course 

proposal emanating from chemistry is brought before Senate 

at its next meeting. 

T. N. Bell 

TNB/md 

.

is

To ?

From

Senate Corrffnittee on Undergraduate Studies 

Subject

New Course Pro 

p

osal - Faculty of 

?

Date

April 19, l974 

...........Sciëhbé:

.........

The Senate Committee on Undergraduate Studies has 

.

examined the 

attached new coarse proposal for Chern±stry 

120 . 

-3:

Clinical Cheiiistry and 

recommends its aPproval to Senate. Should this approval be forthcoming, 

the Ccmnttes Dx'ther 

recorrmends

that the nonal two semester tl!ne 

he waived In order thatthis course may be first offered during the Fail 

semester, 1974. 

It should be noted that the 

offering

of this course represents 

movement into a new area for the Chemistry Department. However, it is 

not anticipated, at this time, that this coarse should form the basis 

for a new program, but rather a means of testing the acceptability of 

such a 

coarse and

the viability of the introduction of this area in the 

Department 

curriculum. Thus, in keeping with the first entry under 

. .

?

Section 

2

of the course proposal form, the Senate Committee on Under- 

graduate Stuc.ics recommends that the course be offered once and evaluated 

before any subsequent offering. 

I. Mugridge 

arns 

att. 

fo

. Senate Committee on 

..................... Vge ... Studies 

Sbect.NE 

"Clinical Chemistry" 

From—

....

Aronoff ? 

. ?

L___.1)

Dean of Science 

Date ...... ...... ?

March ? 

.,i74 

Sc.

" s

'it(3

SIMON FRASER UNIVERSITY

MOfttUM 

The Faculty of Science approved the attached new course proposal, CFIEM 420-3, 

"Clinical Chemistry", at its meeting of March 19,. 1974. It is recommended 

that this course be approved for an initial offering in 74-3. 

1w

Enclosures 

cc:

Chairman, Dept. of Chemistry 

...-.. 

" 1

It

1-•

SIMON FRASER UNIVERSITY

From.,T.......Beli,.. Chairman, 

Subject

Department ofçmitry 

Date ... l7.th 

?

December 

197.3

?

................................................ 

Please find attached course proposal, Clinical Chemistry, 

which was approved by the Department at a meeting held on 

Friday, 7th December 

1973.

It is intended that the course be offered in the fail 

semester 

1974

with no further commitment at this time. Thus I 

would he grateful if you would deal with this proposal in the 

immediate future in order that if approved through the various 

committees, Senate approval can be obtained for a fall 

19714

course mounting. 

The Department is at this time carefully considering curriculum 

development with a view to extending its present offerings to areas 

not encompassed in the present programs of B.Sc. chemistry, biochemistry, 

chemical physics. We anticipate that by extending our offerings in 

the chemistry majors program we can provide options with some 

applied bias which would be not only of benefit to our own Internal 

students, but potentially to off-campus persons. 

The feedback which should result from this particular 

course will be of immense benefit to us in helping guide the 

right kind of future development which the Department wishes 

to undertake. Hence the requirement for mounting this course 

as soon as possible. 

In order to teach this course we would have to use external 

expertise, and thus require an appointment of a sessional lecturer 

for this purpose. The man we would consider for this purpose is 

Dr. R.A. Rockerbie of the Lions Gate Hospital. I request that you 

seek the necessary funding as a parallel action to considerations 

for this course proposal. 

T.N. Bell 

TNB:rdh 

Encl. 

-

\'wook

SENATECOMMITT};E ON' 

UNDERCR/WUATE 

STUDIES 

NEW COURSE 

p Ro p o;AL FORM 

1.

Ca1endr Information 

?

Department: 

Chemistry 

Abbreviation Code: 

Chem ? 

Course Number: 

420

?

Credit Hours: 

Vector: 

-l-O 

Title of Course: 

?

Clinical Chemistry 

Calendar Descriptionof Course: 

An introduction to the biochemical processes 

In the orns, 

ues

Uss

and fluids of the human body and the effect of disease 

these processes. Biochemical methods and laboratory diagnoses as applied to the 

study of disease. 

Nature of Course 

Lecture/Tutorial 

Prerequisites (or Special instructions): 

Chern 252-3, Chem 

121-3 

permission of Department 

What course (courses), if any, is being dropped from the calendar if this course is 

approved: ? 

None - Course Is an elective 

2. Schedl 

Row frequently will the course be offered? 

To be offered once and then evaluated.

Semester in which the course will first be ofleredT 

1974-3

Which of your preoent faculty would be available to make the propoted offering 

possible? 

None 

3.

of

the Cec The present core curriculum and choice of e]ectv' 

dc ? 

not adequately prepare the B.Sc. graduate in chemistry to he of' practical 

vaiue in the clinical laboratory as it now operates within the hospitrt.1 , nublic 

health, or industrial environment. This course will provide the student w:tth 

exposure and some basic knowledge of the health-care field 

and will expand his field of competency generally. Course outlin. attached. 

4.

Bud, 

-,

-

ry and Space Requirements (for information only) 

What additional resources will be required in the following areas: 

Faculty 

?

Appointment of sessional lecturer 

Staff 

?

-

Library ? 

-

Audio Visual 

?

-

Space ? 

-

Equipment ? 

-

5.

Approval 

Date: ? 

/ ?

%((, 

73.

J2'?mic_-' _

JC _LL...._

•Depa tmcnt Chairman 

?

Chairman, SCUS 

SCUS 73-34b:- (When completing 

this form, for instructions see Memorandum SCU: 73-14g. 

Attach course outlinc). 

Course Outline 

The following list of topics are relevant t;o Clinica]. Chemistry. 

A coherent sot from these topics will be presented in this 

course. 

1.

Course introduction, review of development of clinical chem.1;l;rv. 

2.

Differentiation of health and disease, pathological processes, 

concept of normal physiological ranges. 

?

. ?

Quality assurance systems, reference 

materia].s,

error ahal.ysis. 

l.

?

Specimen collection, handling and storage, (Ieproein:izat Len. 

?

5. ? 

Respiratory function and biochemical. ar.i (i-base balance. 

?

1.

?

Disorders and assessment of acid-base € 

:

qui].:i br:Li. ? 

j'lui(l and electrolyte regulation, 

osmol ality

Renal. anatomy,

biochemistry of urine formation 

9.

Assessment of renal function. 

10.

Anatomic considerations of the 

liver, 

bil:i.ruhin metabolism. 

]i.

Liver function tests and their 

role as 

dignostics. 

12.

FJectrophoretic assessment of 

protein 

disturbances. 

15.

The immunoglobulins: 

?

classes, 

structure 

and ? 

function. 

14.

Tmmune mechanisms and deficiency states. 

15.

Amino acids, inborn errors of metabol:i sin. 

16.

Biochemical disorders of carbohydrate metabolism. 

17.

Lipids: methods of transport, interrelationship with 

carbohydrate metabolism. 

18.

Lipoprotein patterns in disease, cholesterol, trig1ycerider. 

19.

Pathophysiology of the thyroid gland: laboratory findings 

in disease. 

20.

Steroid hormones, biochemical interrelationships of the 

pituitary and adrenal glands. 

21.. Laboratory assessment or the pitidtary-adrenal nxis. 

22. Plagnostic enzymology. 

25. Ca rdiac enzyme disturbances and thel r din,griost 1 

r I

nip

I Irat. 1 on::

-2-

24.

Pancreatic secretions and malfunction in disease. 

25.

Biochemistry of the iastf5-inteStiflal system and assessment. 

26.

Malabsorption. 

27.

Principles of pharmacology, classes of drug action. 

28.

Clinical toxicology, 

?

drugs of abuse. 

29 . 

Toxicological analyses. 

30.

Drug interaction in biochemical testing. 

testing. 

31.

Automated analyses, 

?

discrete 

sampling 

and. flow systems. 

32.

Laboratory data processing, and patterns of work-flow. 

33.

Field trip to clinical laboratory. 

34.

Methodology development and criteria for selection. 

35.

Clinical chemistry in industrial and occupational health. 

Library Resources Recommended for Clinical Chem 

20-3

Journals and Periodicals 

Appears to be adequate, 

Clinica Chimica Acta, is not 

very costly (about $125./ann 

many libraries. The journal 

against the cost is probably 

although one leading journal, i.e. 

on the shelves. This journal is 

m) and is being discontinued by 

is desirable but when weighed 

not justifiable. 

Books 

The following should be acquired by the library: 

1.

Tietz, N.W., Fundamentals of Clinical Cncmistry, 1970 

W.B. Saunders. 

2.

Henry, R.J., Clinical Chemistry, Principles and Technics, 

Hari)er and Rowe, 

1964.

3.

Harper, H.A., Review of Physiological Chemistry, 1th ed., 

Lange Medical Publishers, 

1973.

W ?

k. H. Varley, Practical Clinical Biochemistry, Intercience. 

Books Inc., 4-th ed., 

1967.

Recommended Text 

Baron, U.N., A Short Textbook of Chemical Pathology, 

English Universities Press Ltd., 27 

p.

,

1973,

3rd ad. 

* ?

For use as text in proposed course. 