NOTION1: "That Senate approve, and recommend approval to
the Board of Governors, as set forth in S.79-79,
the following new courses:
CHEM 824-3 - Physical Biochemistry
CHEM 825-3 - Bioenergetics."
If Motion 1 is approved,
MOTION 2: "That the following courses be discontinued:
CHEM 821-3 - Advanced Biochemistry
-'I
CHEM 822-3 - Advanced Biochemistry II."
'S
SIMON FRASER UNIVERSITY
MEMORANDUM
To .....................
$enate ..................................................................
.......................
From ....
Office ... of. ... the ... De.an ... o.f ... Graduate ... Studie.s
Subj.ct
............
New Course Proposals
.
Date
..............
June18.....
.
MOTION: That Senate approve the following new courses:
Chem 824-3 Physical Biochemistry
Chem 825-3 Bioenergetics
MOTION: That Senate delete the following existing courses if
the above courses are approved:
Chem 821-3 Advanced Biochemistry I
Chem 822-3 Advanced Biochemistry II
Theses courses were approved by the Executive Committee, Senate Graduate
Studies Committee, on June 4, 1979.
Jon Wheatley
Dean of Graduate Studies
mm!
attach.
I is
SIMON
FKASIiK
UNIVERSITY
?
MEMORANDUM
From ?
.
N...J-Iea.th
.............................. ..
............ Pea
y
.c.Uiaduate. St
i
.idie.s
Ass.t.. to. .Dean. .of. Science
Subject........N.1.
.çQJJS g
.PROP.QSALS...................
Date............19.79.
04 09
..
The following new graduate course proposals were approved by the
Faculty of Sceince at the meeting of 1979 03 13 and are hereby
submitted to the Senate Graduate Studies Committee for consideration
and approval:
CHEM 824-3 Physical Biochemistry
CHEM 825-3 Bioenergetics.
If the above courses are approved, the following existing courses
should be deleted:
CHEM 821-3 Advanced Biochemistry I
CHEM 822-3 Advanced Biochemistry II
Attached please find the approporiate documentation.
c.c. H.M. Evans, Registrar
M. McGinn, Asst. Registrar, Graduate Studies
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SiMON FRASER UNIVERSITY
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MEMORANDUM
•
Dr. R. C. Brooke,
?
Dr. E. J. Wells,
To.............
hairman
....................................From ........ .Chirmah..................................
Faculty Graduate Program Committe
?
- Department of Chemistry
NEW COURSE PROPOSALS
I
?
14 November, 1978
Subect
......................................................
?
Date
.....................................................
I attach New Course Proposal forms for our proposed two
new courses, Chemistry 824-3, "Physical Biochemistry", and Chemistry
825-3, "Bioenergetics". These titles and calendar entries better reflect
current practice in our present offerings as they have developed over
the last several years, and these courses will replace the existing
entries, Chemistry 821-3, "Advanced Biochemistry I", and Chemistry 822-3,
"Advanced Biochemistry II".
The existing course, Chemistry 823-3, "Selected Topics of
Special Biochemical Interest", is proposed to be retained in the calendar
but we see it as being offered less frequently tham the above two new
courses.
These revisions to our graduate calendar entry have been
discussed and approved by our Departmental representatives, by the faculty
involved inbiochemistry, and by the Departmental Graduate Program
Committee. We hope that these amendments to the calendar can be in
place for the 1979-80 edition.
EJW
/ae
These course proposals were approved by the Faculty Graduate Studies
Committee by mail vote in November 1978 and are submitted to Faculty
for consideration and approval.
ii,
N. Heath
Asst. to the Dean
of Science
79/03/02
40
SIU PAM I*IV1TTT
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Chemistry ?
-
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824
Physical Biochemistry -
DsscxiptiossMndvr
_
phyiri1_methndc_pplid_t
_ hin
mluloo
_
oti'uouro
of
nucleic acids, prcteins and membranes.
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it Hoursi
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3
vectors
Lecture _
p
i.rd.ito(.) it
?
none
Isttaat.4 Iarolles_
5 ?
_
Wkou will the eourse tint be otfens
79-1
?
aou oft.a will the coures be offends
A minimum of once every _two years.
JU$UYICAflCPI ?
To equip incoming biochemistry and bioorganic graduate students with
the latest spectroscopic techniques in biochemistry. To broaden the interests of
physical chemists and spectroscopists by applications of physical techniques to
biological problems.
NLMCZSI
Which Faculty ua.r will oonaliy teach
the
courses ?
R.J._Cushley
What are the budstory tlic.tioa. of .oiatin*
the
courses
none
_
-
' A J
lit
f-e
p
IQce
CIet ?
if3
Are there sufficient Library resource. (around d.tsils)t
yes
Ap.nded: a) Outline of the Course
b)
An indication of the co.e.tsnce of the Faculty u.er to *ivs the course.
c)
Library resource.
prov.dz Dspsrtast.l Graduate Studies Cojtti.s ?
_ !Y)
-
Date:
Faculty Oradus
71
S
Senate
?
Graduate
Creduat.
?
Date:
______________
Sonatas ?
_
_Oatst______________
1
Chemistry 824-3
?
Physical Biochemistry
I. Newer Applications of Physical Methods including:
1. Nuclear Magnetic Resonance (NMR) Spectroscopy
a.
Theory of Chemical Shifts.
b.
Theory of relaxation processes.
C.
The Nuclear Overhauser Effect and its applica-
tions in Biochemistry.
d.
Ligand-protein interactions.
e.
Structures of t-RNA.
f.
Proton relaxation enhancement.
g.
13C
Fourier transform nmr and membrane fluidity.
2. Electron Spin Resonance (ESR) Spectroscopy
a.
Theory of ESR.
b.
Spin-labeling of proteins.
C.
Structures of membranes from intrinsic and ex-
trinsic spin-labels.
3. Fluorescence Spectroscopy
a.
Fluorescent probes and protein and nucleic acid
structure.
b.
Rotational correlation times of macromolecules.
1.
Laser Raman Spectroscopy
a.
Structures and dynamics of macromolecules.
b.
Intensity fluctuation spectroscopy
0
-2-
5. Order - Disorder
a.
Introduction to irreversible thermodynamics.
b.
Helix-coil transitions.
C.
Melting
'
of DNA.
The course also includes occasional guest lectures in the
field (e.g., J. Seelig - deuterium magnetic resonance;
E.D. Crozier - extended x-ray absorption fine structure, etc.).
Textbook: Reference texts are Dwek, "NMR in Biochemistry"
and Berimer (ed.) "Spin Labeling Theory and Practice". Re-
ferences, reviews and literature citations will be distributed
throughout the course.
Instructor: R.J. Cushley, Chemistry Department
.
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_A discussion gf the
most import ?
rnceccc frrr hn1rigitl
nergy transduction.?
Structure-functioll relationships of membrane components and/or other interacting
maromfllPC11lT cyctem
Credit Hours;
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3
vector $
1
erture
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..PT.,MU1S&ts(S) ifv$_______
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Whan will the anae first be .ff.tsd$
80-3
am
ottou
will th. couran b. off•rsd;
A minimum of once every two years.
Most of the topics covered in this course are examples of membrane-
associated biological energy transduction. Since many SFU faculty
S.
mnhrc
_
iir
in
_
w'nanv_-at
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C.4jq
?
_heuld be
of interest to their graduate students. The course content also complements the
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ntwnt_
f_whs
_gauate
_
eeure.-
_4IiEH_84,_rPY8_88',_fl._858,_M8C 821, 826,
? 835) which deal with related topics or which emphasize other aspects of bioenergetiC
Rat=;"
Which Faculty .s.r will
sacasUi
teach the ?
_
W. R.Richards
What are
the
budgetary jiieattOna of .sitin* the courls
?
- ?
II re
P
&
c
13
22-3
Are there sufficient Library resources (a
p
.nd d.taii.)
yec
Ap.ndedt a) Outline of
th.•
Course
b)
An indication of
the
co.astsnCs of the Faculty member to
*ivS
the colas..
c)
Library resources
:
_
1
fl
Approved :
Dspartasatal Graduate Studies (jtt4.T4Y_1UMr
?
04 c2?L
Date:
9f .
c\ \-i.
Pseulty Graduate Studies
_______ ______________Data
:./t7
Faculty: ?
/
Senate Graduate Studies Committees
?
(1
Pat*:
flats;______________
Senatsi
CHEMISTRY 825-3
(24 Lectures of 1-1/2 hours each)
1.
?
Introduction and Review (2 Lectures)
a.
Definition of Bioenergetics and General Discussion.
b.
Review of cellular organization, me.brane structure, "high
energy" compounds, substrate level phosphorylation, and the
dissociation of membrane proteins and electron transport
components from biomembranes.
2.
?
Nature of the "Energize State" of Biomembranes (2 Lectures)
a. Membrane-dependant phosphorylatins.
b. Phosphorylation Mechanisms:
(i)
Chemical Coupling hypothesis
(ii)
Conformational Coupling hypothesis
(iii)
Chemiosmotic coupling hypothesis
c. The structure of the "coupling factor" ATP ase.
3.
?
The Proton-Pump of Halobacteria (1 Lecture)
a.
Nature of cytoplasmic membrane in halobacteria.
b.
Bacteriorhodopsis and the proton-pump..
c.
Reconstitution of the purple membrane.
4.
?
Bacterial Photosynthesis (3 Lectures)
a.
Survey of the photosynthetic bacteria.
b.
Isolation of reaction centre and light-harvesting com-
plexes from purple bacterial photosynthetic membranes.
c.
Study of primary light reactions in purple bacteria.
d.
Localization of thylakoid components.
e.
Reconstitution of active thylakoid membranes.
f.
Cyclic electron-transport and photophosphorylation.
g.
Reverse electron-transport and transhydrogenase.
h.
Green sulfur bacterial photosynthesis.
5.
?
Green Plant Photosynthesis (3 Lectures)
a.
Summary of light and dark reactions in green plants.
b.
Photosystem II and the photoevolution of oxygen.
c.
Photosystem I and the photoreduction of NADP.
d.
Isolation of reaction centre and light-harvesting complexes
from chloroplast thylakoids.
...2
.1
Chemistry 825-3 (Cont'd).
?
- 2 -
6.
?
Mitochondrial Oxidative Phosphorylation (2 Lectures)
a.
Isolation of electron-transport complexes from the mito-
chondrial inner membrane.
b.
Redox reactions carried out by Complexes I-IV.
c.
Asymmetry of the mitochondrial inner membrane.
d.
Reconstitution of ATP ase and electron-transport components
into active membrane fractions.
e.
Demonstration of
.
proton and potential gradients and pro-
posed proton-pump in mitochondrial electron transport.
7.
?
Mitochondrial Membrane Transport (1 Lecture)
a.
General discussion of transport systems.
b.
Mitochondrial active transport systems.
c.
Coupling of transport systems in mitochondria.
8.
?
Bacterial Electron Transport Chains (2 Lectures)
a.
Aerobic respiration.
b.
Anaerobic respiration.
C.
Aerobic chemolithotrophiC electron-transport.
d. Anaerobic chemolithotrophic electron-transport.
9.
?
Bacterial transport, Mobility, and Chemotaxis (2 Lectures
a.
Transport systems requiring "energized state".
b.
Transport systems requiring ATP (or other "high energy" com-
pounds).
c.
The structure of bacterial flagella and mechanisms for mobility.
d.
Hypothesis for chemotaxis in bacteria.
10. ?
Other Examples of Membrane Bioenergetics (6 Lectures)
a.
Eucaryotic cytoplasmic membrane transport systems.
b.
Sarcoplasmic
.
retiCUlum Ca transport and muscle contraction.
c.
Axonic nerve impulse transmission; bioelectricity.
d.
Synapic nerve impulse transmission.
e.
Vision: rhodopsin and the rod cell dise membrane.
f.
Membrane receptors.
0
