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-

MEMORANDUM

. ?

Senate 

Senate Committee on Undergraduate 

From ...tudi

........... . ........................

. . . ..

.Xiheidlogy-NEWC01JRSES............... 

60-3 

4

.

IN

K

Subect

Cellular Mechanisms and 

................Theories 

df

AgUig........... 

Aging. 

November 18, 1981 

Date

...................................................... 

.

Action undertaken by the Senate Committee of Undergraduate Studies 

at its meeting of November 3, 1981 gives rise to the following motion: 

MOTION: ? 

"That Senate approve and recommend approval to the Board 

of Governors, as set forth in S.81-156 , the proposed 

new courses 

KIN. 460-3, Cellular Mechanisms and Theories in Aging. 

KIN. 461-3, Physiological Aspects of Aging." 

In discussion it was indicated that these courses are intended as part 

of the regulr course offerings of the Department of Kinesiology but-it also 

is intended that the courses become components of the proposed Diploma Program 

in Gerontology. 

At SCUS there was discussion on the suitablility of the proposed prerequisite 

with decision that no formal change be made. Suitable judgment will be 

necessary on the part of advisors in determining whether or not an individual 

student has adequate background for prerequisites to be waived. 

__0

SIMON FRASER UNIVERSITY

MEMORANDUM

To ?

Mr. H.M. Evans, Registrar and 

?

From

Janet BlantTSecretaI7 to the 

...ctretar. 

..the Senate Cmtt.e 

?

Thteraiscipiinaiy.. 

on

......Un... 

?

Studies. 

............ .

•

i•i 

Subject...... ?

COUR..Q?P.

A

...................

Date.

. . .

P! ? 

r J4, 

.. 81. 

KIN. 460 3 an 

RE: New Course Proposals. 

KIN. 460-3, Cellular Mechanisms and Theories of Aging. 

KIN. 461-3, Physiological Aspects of Aging. 

I.S.C. 81-17 

The. 

above two.

courses were considered and approved at 

a meeting of the Faculty of interdisciplinary Studies hold 

on September 1, 1981. These courses are intended as part 

of the regular course offerings of the Department of Kinesiology, 

but it is intended, that, should the Diploma Program in Gerontology 

be approved, KIN. 460-3 and KIN. 461-3 will also become components 

of that Program. I am forwarding these courses to you for 

inclusion on the next agenda of the Senate Committee on 

Undergraduate Studies. 

JB/pgm 

at t achme n t 

SEP 76 !981

REGISTRAILIS OFFICE

lJLDSK

SiMON FRASER UNIVERSITY

MEMORANDUM

.....

. P.STRt.UIIN. 5HOWN..13.1LOW

..............

From

çlipt,. .S'etaIY....the

Faculty of Interdisciplinary Studies

Date

Re: New Course Proposals

KIN. 4603, Cellular Mechanisms and Theories of Aging

KIN. 461-3, Physiological Aspects of Aging

I.S.C. 81-17

The attached course proposals are being sent to you for

consideration in terms of content overlap. Please let us have

your comments as soon as possible.

C. Hamilton, Chairman, Undergraduate Curriculum Committee,

Faculty of .Arts. (c/o Ili story)

K. Egan, Chairman, Undergraduate Curriculum Committee,

Faculty of Education.

A. Sherwood, Chairman, Undergraduate Curriculum Committee,

Faculty of Science

(do

Chemistry)

For Your Informatipn: ?

C. Bridwell, Library

L)k Evans,. Registrar and Secretary to the Senate Committee on

Undergraduate Studies.

?

• ?

1J'.:.

SENATE COMMITTEE ON UNDERGRADUATE. STUDIES 

NEW COURSE PROPOSAL FORM                    

•

Calendar Information ? 

Department: Kineslology 

Abbreviation Code: 

KIN. ? 

Course Number:460 

?

Credit Hours: 3Vcctor:3-]--() 

Title 

Course: ? 

Cellular mechanisms and theories of aging. 

Calendar Description of Course: 

This course will review the models used in gerontological research at cellular 

and molecular level and discuss the validity of various theories of aging. 

Nature of Course 

?

Three lectures and one tutorial per week. 

Prerequisites (or special instructions): 

BtSC 202-3, K1NES 330, 90 semester hours of credit or permission of the Instructor. 

What course (courses), if any, is being dropped from the calendar if tlliu course J.s 

approved: 

None 

2.

Scheduling 

How frequently will the course be offered? ? 

Once a year 

Semester in which the course will first be offered? 1983-1 

Which of your present faculty would be available to make the proposed offering 

ossible 

• None (Except within the Budgetary Accommodation shown below) 

3.

Objectives of the Course 

To review the status of cellular mechanisms implicated in various theories of aging 

and discuss the multi-disciplinary approach required for understanding the process 

of aging. 

4.

tary and Space_Reqiirements (for information only) 

What add t lonal resources will be required in the following areas: 

Faculty ? 

1 full-time Faculty and Teaching Assistant 

Staff 

Library 

Audio Visual $600 

Space 

Equipment 

'

?

.

?

Department Chairman 

?

'—V-----------Dean 

' 1'• 7 --

? ?

hatrmafl, SCUS 

.

SCUS 73-34h: (When completing,this form, for instruct ions see Memorandum SCUS 73-34. 

KINESIOLOLGY 460-3 

THEORIES AND CELLULAR MECHANISMS OF AGING 

COURSE OUTLINE 

1.

Comparative Biology and Evolution of Aging 

Comparative Biology of Aging 

Comparative Longevity in Verbebrates and Invertebrates 

Factors contributing to the longevity of Animals 

Manifestations of Aging 

The Evolution of Aging and Longevity 

2.

The Molecular Genetics of Aging 

Mutation and Error 

Chromosomal Aberrations 

Mutation in the Germ line 

The rate of somatic mutation 

Are aging mutations dominant pr recessive 

Chemical changes in DNA 

Repair and Life span 

Aging, mutation and repair 

Programmed aging 

Altered phenotype as a cause of Aging 

Must aging repair recapitulate ontogeny? 

Residual protein of DNA 

?

.

Satellite and Redundant DNA 

Messenger RNA 

?

..

Transfer RNA 

?

.

End product analysis 

3.

Macromolecular metabolism during Aging 

Regulation of enzyme activity 

General metabolism of DNA, RNA and Protein 

Control of metabolic reactions 

Enzyme changes with Age 

Lipid metabolism 

Energy metabolism 

4.

Cell Division and Cell cycle 

Effect of Aging on the cell cycle times and growth fraction 

Effect of Aging on biochemical events occuring in the cell 

cycle 

Lengthening of G 0 

as an expression of senescence 

5.

Cell Lonevity in vivo 

Cell culture 

In vivo aging studies and experimental design 

In situ observations of cell proliferation 

Serial transplantation: limited or unlimited life 

.

span? 

Role of cell division, in cellular aging 

?

The influence of donor age 

?

.

Tissue interactions and aging 

Transplantatipn-induCed alterations in cell regulation 

2.

• ? 

Cellular transformation and in vivo aging. 

6.

The Cellular Basis of Biological Aging 

.The inverse relationships between donor age and culture 

longevity 

Progeria and Werner's syndrome 

The finite lifetime of cultured normal chick cells 

Cultured normal fibroblasts from other vertebrates 

Functional decrements that occur. in cultured normal human 

cells 

• ? 

Possible correlation between population doubling potential 

of cultural normal fibroblasts and mean maximum species 

Can

life 

cell death be 

span.. 

normal? 

7.

Genetic Basis for Lonqevit 

The statistical facts 

Evidence from sex differences 

Evidence from species-specific life spans 

Evidence from twin longevity data 

8.

The Programmed Theory of Aging 

Sequences of built-in events 

Selective pressures 

. ?

Reasons for the existence of aging 

Survival and natural selection 

9.

Free Radicals and the Aging Process 

Free radicals and lipid peroxidation 

Lipid peroxidation in vivo 

Free radical-induced pathology in aging 

Antioxidant effects in aging 

Lipofuscin and aging pigments 

10.

Chemotherapeutic techniques in the retardation of9ing 

process 

Gerovital H3 Vs Procaine HC1. 

Clinical studies in North America 

Mono amine oxidase and aging 

11.

The study of Aging in man: Practical and theoretical 

problems ? 

. ?

. ?

.

Genetic . mish-mash . . 

?

. .

Environmental Diversity 

Population sampling 

Interaction of aging and disease 

. ?

12. A new age-scale for humans 

Life span of animals and plants 

Factors affecting the life span of mn 

Parameters measuring the life span of HomosapienS 

SENATE COMMITTEE ON UNDERGRADUATE STUDIES 

?

NEW COURSE PROPOSAL FORM 

1. Calendar Information ? 

Department:KINESIOLOGY 

?

.

Abbreviation Code: 

KIN., 

?

Course Number: 

461 ? 

Credit Hours:3 

?

Vcsi:or: 3-1-0 

Title of Course: Physiological Aspects of Aging 

Calendar Description of Course: 

This course is designed for those who require a serious but fairly 

broad discussion of specifiô physiological aspects of aging. The 

overall emphasis is on humans and other mammalian species and the 

varieties of aging changes they manifest. 

Nature of Course 

Three lectures and one tutorial per week. 

Prerequisites (or special instructions): 

Kin 305 and 306; At least 90 semester hours of credit or permission 

of the Instructor 

What Course (courses), if any, is being dropped from the calendar if this; course is 

approved 

• ? 

None 

2.

SchduUn 

How frequently will the course be offered? 

At least once a year 

Semester in which the course will first be offered? 

1982-3 

Which of your present faculty would be available to make the proposed offering 

possible? 

None (Except within the Budgetary Accommodation shown below) 

3.jectives 

of the Course 

'ro reviewhe status of physiological and biochemical knowledge in 

gerontology from molecules to man. Although future, research in 

Gerontology will certainly radically alter our views on the nature 

of biological aging and its relation to the quality of life in the 

later years, it is hoped that the topics covered in this course will 

provide a useful entry into the very diverse areas of this rapidly expandi.. 

4. Budtory and Space 'Requirements (for information only) 

?

field. 

What additional resources will be required in the following areas: 

Faculty ? 

1 full-time Faculty and.Teaching Assistant 

Staff 

Library 

Audio Visual 

?

$600 

Space 

Equipment 

5. Approval? 

Date: 

Department Chairman 

,ci7

I3ean ? 

'thairman, SCUS 

sctjs

73-341): 

?

(When completing this form, for instruct ions see 

Mcrnor;iriditn SCUS

73-34a.

:it

ta(h

i(11

r:( oii I 

.KIN 461-3 

PHYSIOLOGICAL ASPECTS OF AGING 

Course Outline 

1.

ANATOMIC AND BODY COMPOSITION CHANGES WITH AG.rNG 

Changes in Stature 

Changes in Body Fat 

Other AnthropometriC Changes 

Body Compostion Changes 

Anatomic Regression Related to Diminishing K Content 

Other Morphologic Changes 

Aging and Pathology 

2.

INTERCELLULAR MATRIX OF CONNECTIVE TISSUE 

The Mati 

The Macromolecules 

The Tissues 

3.

AGING OF THE SKIN AND ITS APPEND/ICES 

Biologic Features of Aging Skin 

Geriatric DermatoSeS 

Progeroid Syndromes 

•,-. 

?

Dermal Tissue Culture 

4.

AGING OF SKELETAL-DENTAL SYSTEMS AND SUPPORTING TISSUES 

Skeletal System 

Dental System 

5.

MUSCLE 

Historical Aspects, Research Trends, and Methodology 

Changes in Aging Muscles 

Factors Affecting the Rate of Changes in Senescent Muscles 

6.

NEUROENDOCRINE AND AUTONOMIC APSE CTS OF AGING 

The Problem of Aging and Disease in the Central Nervous System 

Overview of Cellular Functions in the Central Nervous System 

during Aging 

Synaptic Function and Neurotransmitters 

NeuroendoCrirle Function and Aging 

AutonomiC Mechanisms and Aging 

7.

HEART AND CARDIOVASCULAR SYSTEM 

Functional Changes with Age 

Cardiovascular Disease and Age 

Basic Aging Processes 

2.

?

S. ? 

AGING OF THE EXCRETORY SYSTEM: KIDNEY AND BLADDER 

Changes in Renal Anatomy with Age 

Renal Physiology 

Compensatory Renal Hypertrophy 

The Bladder 

9.

AGING OF THE REPRODUCTIVE SYSTEM 

Female Reproductive System 

Male Reproductive System 

10.

ENDOCRINE SYSTEMS 

Insulin 

Proinsulin 

Glucagon 

Thickening of Capillary Basement Membrance-Relation to Aging 

to Diabetes: Mellitus 

Anterior Pituitary 

Growth Hormone (GH) 

Thyrotropin (TSH) 

Adrenal Cortex 

Glucocortidoids 

Adrenal Androgens 

Thyroid 

Effect of Age on the Mechanisms of hormonal Action 

11.

IMMUNITY AND AGING 

The Immune System 

Age-Related Changes in Immune Functions 

Disease Associated with Age-Related Decline in Normal Immune 

Functions 

Methods Used to Analyze Immunodeficient States 

Nature, Cause(s), and Mechanism(s) of Decline with Age in Normal 

Immune Functions 

Immunoengineering 

12.

AGING AND GASTROINTESTINAL FUNCTION 

Esophagus 

Stomach 

Small Intestine 

Colon 

Liver 

Pancreas 

Gall Bladder 

?

Ii.

NIJTR7TION

Effect of Age on Nutritional Status. 

Nutritional Deficiencies and Physiological impairments 

Reversal of Deficiencies by Supplementation 

Food Additives 

Dietary Restriction 

3.

14.

EXERCISE AND AGING 

Acute responses to Exercise 

Static Effort 

Dynamic Effort 

Chronic effects of Exercise 

Lifelong physical activity 

Aging of "Primitive" groups 

15.

ALCOHOL AND OTHER DRUG USE IN THE AGED 

Consequences of prescription drug use 

Alcohol 

Misues of other drugs 

16.

LIFE TABLE MODIFICATION AND LIFE PROLONGATION 

The Relation of Mortality to the Physiological State of the 

Organism 

Environmental and Genetic Determination of the Survival 

Characteristic 

Relation of the Survival Characteristic to. Temperature 

and the

Rate and Quantity of Metabolism: Poikilotherrnic Organisms 

Relation of the Survival Characteristic to Temperature and 

the Rate and Quantity of Metabolism and Function: 

•

?

Homeotherntic Vertebrates 

17.

SYSTEM INTEGRATION 

Homeostasis 

Control Mechanisms 

Temperature Regulation and Control 

Regulation of the Acid Base Balance of-the Blood 

Regulation of Blood Sugar Levels 

Other Endocrine Regulation 

Physiological Stress of Exercise 

Other Environmental Stresses 

Aging as the Breakdown of Regulatory Mechanisms 

18.

FACTORS IN HUMAN MORTALITY 

Measures of mortality 

Causes of death 

Age trends in death rates 

Biological factors in mortality 

Environmental factors in mortality 

Implications of reduced mortality 

0--,

SiMON FRASER UNIVERSITY

MEMORANDUM

Marilyn Muter 

?

From Maurice Deutsch 

.Registrar's Office 

?

.

?

Library - Science Division 

(3269)

Subject.... 

?

Date ?

September 

1981 ?

. . .

With regard to the following new course proposals 

KIN. 460-3

Cellular Mechanisms and Theories of Aging 

KIN. 461-5

Physiological Aspects of Aging 

I am waiting for the results of computer searches which were 

run on CISTt's (Canada Institute for Scientific and Technical 

Information) Library Catalog and the Union List of Scientific 

Serials in Canadian Libraries to compare with the book and 

journal collections in the SFU Library. 

The Library's book and journal collections in the area of the 

physiology of aging look very lean. There are about 70 bobks 

and perhaps half a dozen journals, but I will not be able to 

determine where-we stand until the computer printouts arrive from 

Ottawa. 

Ii

Jr

?

• ?

SiMON FRASER UNIVERSITY

-. ?

MEMORANDUM

To.......

Subject

.....................................................

Faculty of Interdisciplinary

S ?

Date.....

.Qc.t.Q1).X. ?

.......................

.

Re: Proposal for a Diploma Program in Gerontology 

(I.S.C. 81-12) 

Attached is a copy of a memorandum received from the 

?

Faculty of Science Undergraduate Studies Committee concerning 

overlap. 

JB/pgm 

C.C.

Dr. G. Gutman 

ATTACHMENT 

OCT277987

.

. ?

SiMON FRASER UNIVERSITY

MEMORANDUM

?

Interdisciplinary Studies, 

?

From ......

A.

Chairman, 

•

(  Sherwood 

•

raculty 

?

o' r $cience 

(Jnde 

?

yate, 

.

..'. 

?

1

•

?

I .

In response to your memo of Sept. lo, there 

appears

to he no serious 

overlap of content between courses in the a1)OVC program and courses given 

by the faculty of Science. 

The program has, however, been discussed by members of the faculty 

With interest in areas such as physiology, genetics and developmental 

biology. The following questions 

were raised

about. the courses KTN 460 

and KIN 461. 

(1)

These courses seem to have more scope than can possibly be 

handled at the 400 level in a single semester by students with the 

background indicated by the suggested prerequisites. 

(2)

The subject matter outlines for these courses appear to be 

appropriate for an upper level medical school program and the question 

arises as to whether such courses will he of real 

USC

to persons associated 

with the planning and 

delivery of services to

older people" ic. "social 

workers, recreation directors, nurses and other health care professionals". 

I hope that these remarks are useful, in the planning of the 

Gerontology program. 

A.Q. Sherwood 

A( ;S a K 

c.c.. or. C. Rhakthan 

Dean Cochran 

Dr. J. Webster 

Assoc. Acad. V.P. 

.

to