SiMON FRASER UNIVERSITY

S,90-107

MEMORANDUM

As amended and approved by SQJS to

Aug. 5/80 and by

EtS(1

to Jul. 7/80

To

?

- ?

4:J__

A.

MIWR IN RWIRatMqTAL

Subject -. ?

ió)11 ?'

B.

EXnNDED

STUDIES DIPLCMA IN

From SENATE COM!IITrEE ON UNDERGRAWAIE

STUDIES AND EXEXUT..I, SEN1,TE

GRADUATE STUDIES CO4,4n'rEE

Date. AUGUST 8, 1980

S

Action taken by the Senate Caxrnittee on Undergraduate Studies

at its meeting of August 5, 1980 and by the Executive Cournittee, Senate

Graduate Studies Crnittee on July 7, 1980 gives rise to the following

motion:

That Senate approve, and recxmnd approval to the Board

of GDvernors, the proposed Minor in Environmental Toxi-

cology, the requirements for an Extended Studies Diploma

in Environmental Toxicology, the proposed

new

undergraduate

courses, and

the

proposed new graduate courses, as set

forth in S.80-107, specifically:

a-).

Proposed Minor in Envirortnental Toxicology, including

i)

Lower division courses as prerequisites for the Minor

ii)

Upper division course requirements - including the

usual requirements for caipletion of degree

b) Requirements for the Extended Studies Diploma in Environ-

mental Toxicology

c) Proposed new undergraduate courses:

i)

BISC 311-3 - Introduction to Environmental Toxicology

ii)

GIEM

371-3 - Chemistry of the Environment I

iii)

GEDG 319-3 - Physical Interactions in the Environment

d) Proposed new graduate courses

i)

BISC 650-3 - Industrial Toxicology

ii)

BISC 651-3 - Food and Drug Toxicology

iii)

BISC 652-3 - Problem Analysis in Environmental Toxicology

Note: It is intended that the programs be operated through the

Department of Biological Sciences with the cooperation of the

Departments of Chemistry and of Geography.

There

is request for a new Minor in Environmental Toxicology

offered within the Bachelor of Science degree. There is also

request for an Extended Studies Diploma in Environmental

Toxicology.

G

---

SiMON FRASER UNIVERSITY ?

MEMORANDUM

As amended and approved

by SCUS to Aug. 5/80

seus

gb,

JOHN CHASE,

SECRETARY

From.,

?

. ?

.

SENATE COMMITTEE ON ACADEMIC PLANNING

Date..

JULY 11, 1980

To.

?

H. EVANS, SECRETARY

SENATE

COMMITTEE ON

UNDERGRADUATE

Su

?

PROPOSED ENVIRONM4TAL TOXICOLOGY

A. MINOR IN ?

.:4.)lç'

EXTENDED

B.

?

STUDIES DIP10M IN ENVIM092fML

TMOXICOJ

Action taken by the Senate Carirnittee on Academic Planning at

its meeting on July 9, 1980 gave rise to the following notion:

That the Minor and Extended Studies Diploma programs

in Environmental Toxicology as described in SCAP 80-10

be approved and forwarded to SCUS and Senate for

consideration and approval.

Since the two proposed programs contain two new courses (BISC

311-3, Introduction to Environmental Toxicology and CHEM 371-3,

• ?

Chnistxy of Environment 1) would you please see that the SCAP

notion and acnpanying papers are placed on the agenda of a sub-

sequent meeting of the Senate Cc:mnittee on Undergraduate Studies.

Registrar's Note: The proposal includes a new course in Geography:

GEOG 319-3 - Physical Interactions in the Environment.

---

a ?

a

SIMON FRASER UNIVERSITY

?

MEMORANDUM

To

?

From..

OFFICE.

GRADUATE CURRICULUM CHANGES - NEW

Subject ........ .

çQURS

.

E

PROPOSALS.,.. JISC

650-3,651-3.,.. ?

Date.. . JULY .14.,..

.1980....................................................................

AND 652-3

These courses were approved by the Executive Committee,

Senate Graduate Studies Committee, on July 7, 1980.

Bryan P. Beirne

Dean of Graduate Studies

0

---

iviui r nttrn ui'i v ruY'

MEMORANDUM

Dr.

J.

Chase Secretary

From ?

N.

Heath

Assistant to the Dean

Senate Conunitteeon

Academic Plannin

?

Faculty of Science

Subject ?

PROPOSED ENVIRONMENTAL

?

Date.

?

1980 06 12

TOXICOLOGY PROGRAMS

At the meeting of 1980 06 05, the Faculty of Science approved

the following motions:

"That the new course proposals BISC 311-3, Introduction to

Environment

al

Toxicology, and CHEM 371-3, Chemistry of

Environment I, as described in F-80-13, be approved and

forwarded to scus and Senate for consideratio

n

and

approval."

"That the Minor and Extended Studies Diploma programs in

Environmental Toxicology as described in F-80-13, be

approved and forwarded to scus and Senate for consideration

and approval."

A third motion was also passed approving the graduate?

course proposals BISC 650-3, Industrial Toxicology, BISC 651-3,

•

?

Food and Drug Toxicology and BISC 652-3, problem Analysis in

Environmental Toxicology. These proposals have been forwarded

to the Senate Graduate Studies Committee.

The following documentation is attached:

Part 1. ?

Proposal for a Minor and Extended Studios

Diploma Program in Environmental Toxicology (F-80-13)

including:

-- Descriptions of the proposed new programs.

-- New course proposal forms for BISC 311-3 and

CHEM 371-3.

-- A COPY of the course proposal form for GEOG 319-3,

Physical Interactions in the Environment (previously

submitted to SCUS by the Faculty of Arts).

-- Copies of the course proposal forms for BISC 650-3,

651-3, 652-3, as submitted to SGSC.

Part2. ?

Course overlap information for the proposed new

dergradute courses.

Part 3. ?

Memorandum from M. Mackauer to J.M. Webster

concerning additional resources needed to mount the

Programs.

Part 4.

?

Statement from E. Weinstein on Library resources

is

?

for new course CHEM 371-3.

2/

---

Page 2

1980 06 13

Part 4.

?

Report by M. Deutsch on Library resources

(Continued) for the new courses in the Minor and ESD Programs.

N. Heath

NH/mgj

Attachments

---

SiMON FRASER UNIVERSITY

MEMORANDUM

0

Subject ?

.

M. McGinn

Secretary

Senate Graduate Studies Committee

NEW COURSE PROPOSALS BISC 650-3,

651-3, 652-3

N. Heath, Administrative Assistant

From

to the Dean of Science

1980 06 12

Date

.............................................................................................

At the meeting of 1980 06 05, the Faculty of Science approved the

following motion:

"That the new course proposals BISC 650-3, Industrial Toxicology, BISC 651-3,

Food and Drug Toxicology and BISC 652-3, Problem Analysis in Environmental

Toxicology, as described in F-80-13, be approved and forwarded to Senate

Graduate Studies Committee for consideration and approval."

The document referred to in the motion contains the respective course

proposal forms and proposals for a Minor Program and an Extended Studies

Diploma Program in Environmental Toxicology. Neither of these programs

is at the graduate level, but in order to explain the context of the course

proposals submitted, I have included an edited version of document F-80-13.

I attach also a memorandum from Dr. Mackauer to Dean Webster concerning

S ?

the need for additional resources (faculty, equipment, etc.) if these courses

are approved.

N. Heath

NH/mgj

End.!

.

1

---

F- ro

-)3

PROPOSALS FOR

A.

MINOR PROGRAM IN ENVIRONMENTAL TOXICOLOGY

(within a B.Sc. Degree)

B.

AN EXTENDED STUDIES DIPLOMA PROGRAM IN

ENVIRONMENTAL TOXICOLOGY

Prepared by

DR. C. VAN NETTEN

and submitted by

THE DEPARTMENT OF BIOLOGICAL SCIENCES

Environmental toxicology is the science that deals with the

adverse effects of chemical and physical agents on living organisms

in the environment. Although the significance of environmental

toxicology as an area of national concern is widely recognized, no

Canadian university currently offers a program in the area. As a

result, many Canadian students now go to the United States of America

where 6 such programs are available.

Information obtained from students enrolled in pilot courses

offered in 1978 and 1979 at Simon Fraser University indicates that

there are two types of students with an interest in environmental

toxicology: undergraduate students who wish to specialize

• in

environmental toxicology and graduate students who are already

employed in areas related to environmental toxicology and wish to

upgrade their training. To satisfy these needs we propose to offer

a Minor program and an Extended Studies Diploma program in Environ-

mental Toxicology. The Minor will require 3 new undergraduate courses,

one each to be offered through the Departments of Biological Sciences,

Chemistry, and Geography. The proposed Extended Studies Diploma program

includes the courses required for the Minor, several existing

graduate courses and 3 new graduate courses.

The proposed programs in Environmental Toxicology will be offered

through the Department of Biological Sciences with the

,

co-operation of

the Department of Chemistry and the Department of Geography. Depending

on enrolment growth, the Minor program may be expanded .into a Major

program and/or a graduate program leading to a M.Sc. degree in

Environmental Toxicology.

2

?

80/03/11 Revised 1980 05 14

---

S

?

2.

Introduction.

Environmental toxicology, defined as the science that deals with the

adverse effects of chemical or physical agents on living things in the

environment 1

,

is rapidly expanding. The public and private concern about

environmental problems such as mercury pollution, food additives, pesticides

and herbicides, demands more information before these problems are dealt with.

In order to prevent accidents it is essential to know when, where and ho a

hazardous substance, released into the environment by accident or design, is

most likely to exert its toxic actions. Only once this information is known

can appropriate counter measures be taken. At present, dangerous situations

often develop because the toxic action of a particular substance has not been

properly assessed resulting in faulty predictions, often followed by serious

damage to the environment and the organisms living in it.

Until recently the predictions of potential hazard were largely

based on data obtained from experiments which subjected a test organism to

various concentrations of a given chemical agent. Although this approach

provides valuable information regarding toxicity, it is a poor indicator of

the actual hazard a substance might pose when it is released into the environment.

In order to estimate a potential hazard the interaction of the chemical

agent and the environment should be studied. These interactions may include

. ?

parameters such as wind dispersal, soil binding, microbial breakdown and

conversion, bioconcentration, as well as possible synergistic and antagonistic

effects with other substances present.

As an illustration of these concepts consider the interaction of

mercury with the environment. Mercury in its metallic form has a certain

toxicity which is modified by the presence or absence of other substances.

For instance, the toxicity of mercury is greatly enhanced when it interacts

with copper. This element acts synergistically with mercury, i.e. the

combination of these two elements produces a hazard which is much greater

than the sum of their individual effects. Similarly, the presence of selenium

will have an antagonistic effect, protecting the organism to a large extent

against the harmful effects of mercury. Microorganisms may convert elemental

mercury to methyl mercury, a compound with an entirely new set of chemical,

physical and biological properties. This compound is one hundred times more

toxic-than elemental mercury, is selectively stored in muscle tissue, has

synergistic effects with nitrites and, as some recent reports suggest, has

antagonistic effects with vitamin E, vitamin Bl, and vitamin C.

If, for example, one were to assess the hazard of mercury toxicity

among the Inuit, one would have to consider if these people use nitrites to

cure fish and meat which might be contaminated with methyl mercury.

It is clear therefore that, in order to estimate the hazard produced

by mercury or any other substance, one must be aware of, consider, and

investigate often superficiall

y

unrelated factors. The study of the field

of environmental toxicology attempts to identify these factors and evaluate

• ?

their importance.

3

---

3.

Many aspects of environmental toxicology are presently dealth with in

courses given in the biological and other sciences.

?

Often a particular

example from environmental toxicology is used to

illustrate

an

academic

principle. ?

Although this approach often appears adequate, severe deficiencies

have become apparent.

?

For instance, the

interaction

of a

particular substance

with the whole environment, and how its toxic effects integrate with the

effects produced by other substances present,

is not adequately dealt with.

Demand for courses In,environmental toxicology and for

toxicologists.

Information gathered from students that were

enrolled in pilot courses

in environmental toxicology as well as from potential students presently

employed by government and industry (appendix 1), indicates that there are

two categories of interest for enrolling in courses in environmental toxicology.

A. ?

Student working towards a bachelors degree in the sciences

who would like to supplement their

degree

with practical

information in environmental toxicology which will aid them in

finding employment in areas of

their interest.

B. ?

Students who are already employed in areas concerned with

environmental problems who have come to

the realization that

their training is lacking in certain areas essential to the

understanding and assessment of the problems they are dealing

with.

These students as well as

their

employers, are

looking for universities that

offer courses in environmental toxicology which:

a.

?

Provide a detailed and integrated view of the field of

environmental toxicology,

b. ?

Provide information regarding the

latest

sampling and assay

techniques as well as

the evaluation

of

data generated by

these techniques.

C. ?

Provide experience with laboratory equipment that

is presently

used to monitor toxic agents in the

environment.

d. ?

Are designed and coordinated in such a fashion that they can

serve

as a guide to the prediction of

the environmental impact

of toxic agents when they are released,

in

a

given location.

Presently, there is no Canadian university or college which offers a

program in environmental toxicology. 2 A few institutions,

however, are

offering individual courses in this area. Simon Fraser

University has

offered such a course since 1976 on a regular basis, The

University

of Toronto

has recently become involved, September 1979, and is offering a course in

Interdisciplinary Toxicology. At various institutions, however, there are

related programs such as Environmental Studies,

Industrial Hygiene and

Occupational Health. Environmental Studies tend to centre around urban

planning and development, whereas Industrial Hygiene and Occupation

Health

are concerned primarily with monitoring and control of exposure to toxic

substances around the work place. ,

---

. ?

4.

None of these programs address environmental issues directly and are

not concerned with the fundamental basis of these problems; that damage

to a particular environment is caused by the physiological and biochemical

effects of toxic agents on the organisms living in it. A thorough knowledge

of these effects and of the environment is therefore essential to the

proper assessment of a particular problem and consequently to the design of

possible answers.

Because of the lack of such program in Canada, manh employers have

sent their employees for retraining and upgrading, at great investment of

time and money, to universities in the United States where six program

specifically addressing the field of environmental toxicology are available.

(Appendix 2).

The demand for formal training in environmental toxicology and for

toxicologists has recently been emphasized

4

, 5

and is perhaps best demonstrated 4

with the following quotation taken from a recent issue of the Journal, Science.

"Toxicologists are in great demand - but short supply - in

both the regulatory establishment and the private sector. In

the government alone, more than 2000 toxicologists are expected

to be employed by 1985, up from a relative handful now working

in each of the large agencies, such as the Food and Drug

Administration, Environmental Protection Agency, Occupational

. ?

Safety and Health Administration, and Consumer Product Safety

Commission."

The Canadian government is presently assessing the extent of the

demand for trained personnel in toxicology but has, to date, not come up

with any definite figures.2

List of References

1.

Draft proposal for a "Subcommittee on Toxicology of the

Associate Committee on Scientific Criteria for Environmental

Quality."

Attachment I, Page 2, October 31, 1979. National Research Council.

2.

Personal communication with I. Hoffman, Head, Environmental

Secretariat, National Research Council of Canada.

3.

J. B. Olishifski and F. E. McElroy editors, Fundamentals

of Industrial Hygi,

ene

National Safety Council, Chicago, Ill. 60611.

4.

"Toxicologists Struggling for Federal Identity." Science, Vol. 203,

January 12, 1979.

5.

"Wanted: More Toxicologists," EPS Journal, Vol. 4, No. 8,

September 1978.

6.

Personal communication with Paul B. Hammond, Professor of Environmental

Health, Kettering Laboratory, University of Cincinnati Medical Center.

---

Program proposal and requirements.

In order to satisfy the demand for meaningful, integrated and

applicable information in environmental toxicology which is relevant to

Canadian environmental problems, a minor program (for the category A students)

and an extended studios diploma program (for the category B students) in

this field is proposed.

Because of the dynamic nature of the field of environmental toxicology,

with issues and problems changing from time to time, it is important for any

successful program to have direct feedback from the public, the government

and the industry. This feedback will be provided by the extended studies

diploma students who have been working in the field, have identified information

gaps, and have come to the university for additional training. The combination

of these two, although independent, programs will ensure that students working

towards a B.Sc. with a !nor in Environmental Toxicology will be trained in

areas where they are most useful to government and industry.

The proposed programs are ideally suited for integration with many of

the already existing programs such as pest management, resource management,

criminology (forensic science), kinesiology, marine science, computing sciences

and biochemistry. In addition integration with non-academic programs such as

the cooperative education program is highly desirable and a realistic possibility.

The proposed program may be viewed as a natural evolution of material

dealt with in many areas of biological sciences but which has been integrated,

and supplemented in order to provide a comprehensive view and understanding

of current concepts of environmental toxicology.

?

0

Objectives

of -the To Programs

A.

?

Minor Program in Environmental

Toxicology

1.

To give undergraduates who are working towards a degree in the

sciences an opportunity to obtain a thorough overview of the

field of environmental toxicology.

2.

To make these students better qualified, and consequently

eligible for employment with various industrial and government

agencies engaged in environmental monitoring and research and

where, in the past, a large proportion of the science graduates

have found employment.

B.

?

Extended Studies Diploma Program in Environmental

Toxicology

1.

To enable students, who already have a B.Sc. in the sciences and

who are presently engaged in environmental work, to update

their training, to fill information gaps, and to familiarize

themselves with other areas of environmental toxicology of which,

they might not be aware but which are essential to the recognition

and assessment of potentially hazardous situations in the environment.

2.

To provide these students with practical experience in recent

laboratory assay techniques enabling them to critically evaluate

the data generated by these techniques.

---

06.

3. ?

To give the students a guide to the prediction of the environmental

impact of a toxic agent when released, by accident ordesign,

so that appropriate precautions are taken before damage is done

to the environment and its population.

Environmental Toxicology, Course Proposal5

A total of eight courses, six of which are modified or new courses in

various departments, are proposed as core courses for the Environmental

Toxicology

programs.

Course outlines and detailed description of new courses are attached.

CORE COURSES.

The core courses can be sub-divided into two groups.

#1.

Undergraduate, Introductory Courses.

BISC. 432-2, Chemical Pesticides and the Environment.

BISC. 311-3, Introduction to Environmental Toxicology.

CHEM. 371-3, Chemistry of the Environment.

GEOG. 319-3, Physical Interactions in the Environment.

.

?

And one course from the following:

BISC. 329-3, Experimental Techniques.

CHEM. 357-3, Chemical and Instrumental Methods of Identification

of Organic Compounds.

CHEM. 416-3, Modern Methods of Analytical Chemistry.

*

#2.

Graduate Courses.

BISC. 650-3, Industrial Toxicology.

BISC. 651-3, Food and Drug Toxicology.

BISC. 652-3, Problem Analysis in Environmental

Toxicology.

* BISC 650-3 and 651-3 are available for credit to M.Sc. and Ph.D. students in

Biological Sciences

?

on the recommendation of the student's Supervisory

Committee.

Requirements

A. ?

Requirements for entry to the Minor Program in Environmental Toxicology

Lower division courses as prerequisites (33 semester hours minimum)

BJJSC 101-4, 102-4, 201-3

(HEM 104-3, 105-3, 115-2, 251-3, 256-2, 232-3, 261-3

GEOG 111-3

MATH 101-3, 154-3, 155-3

.

PHYS 101-3

B. ?

Requirements for entry to the Extended Studies Diploma Program in

Environmental Toxicology

Entry into this program is restricted to students who have graduated with

a bachelors degree in one of the sciences.

7

---

7.

Course requirements for a MINOR in Environmental Toxicology

This program may be undertaken within the B.Sc. degree.

Upper div-ison requirements (15 semester hours minimum) chosen from the core

courses described above in #1.

15-16 hrs.

.4 ?

If credit for any of the above core courses is already being used

towards another degree or diploma, additional credits will have to be

obtained from the courses listed below in order to satisfy the minimum

credit requirements of 15 semester hours in upper division courses for

a Minor in Environmental Toxicology.

None of the courses listed below can be counted towards the

requirements for more than one program.

BICH. 301, 412, 440

BISC. 301, 305, 347, 401,405.

KIN. 405,406.

Due to the infrequent offering of certain courses, it

is advised

that students wishing to pursue a Minor in Environmental Toxicology

contact the Department of Biological Sciences as soon as possible.

Realizing that many of the prerequisite courses for an Environmental

Toxicology Minor are already required for the various Major degrees

it is helpful to summarize those courses which are not included in

the prerequisite requirements for students in certain disciplines.

Prerequisite courses for a Minor in Environmental Toxicology

to be taken in addition to those required for the following

major program.

BISC.

Majors.

CHEM.

2323, 261-3

?

6

GEOG. 111-3

?

3

Total

BICH.

Majors.

8

BISC. ?

201-3

3

CHEM.

232-3

3

GEOG. ?

111-3

3

MATH.

?

101-3

3

Total ?

12

CHEM. Majors.

BISC.101-4, ?

102-4, ?

201-3

11

GEOG. ?

111-3

3

MATH.

101-3

3

17

Total

---

1

GEOG. Majors (B.Sc.)

BISC. 201-3

CHEM. 251-3, 256-2, 232-3, 261-3

KIN. Major.

S

8.

3

11

Total

?

14

-V

3

3

3

3

Total ?

12

CHEM.

232-3

GEOG.

111-3

MATH.

101-3

PHYS.

102-3

---

9.

Course Requirements

for an Extended Studies Diploma Program.

Option A.

Industrial Toxicology.

Core courses group 1

15-16

hrs.

BISC.

650, Industrial Toxicology

BISC.

652, Problem Analysis in Env. Tox.

9

hrs.

BISC. 846,

Insecticide Chemistry and Toxicology

(6 hrs of electives in upper division courses in

consultation with a faculty advisor.)

6

hrs.

30-31

hrs._

Option B.

Food and Drug Toxicology.

Core courses group 1

?

15-16 hrs.

?

BISC.

651, Food and Drug Toxicology

BISC.

652, Problem Analysis in Env. Tox.

?

12 hrs. ?

BISC. 846,

Insecticide Chemistry and Toxicology

BISC.

405, Cell Physiology

3 hrs. of electives in upper diviioncoursés in

consultation with a faculty advisor.

?

3 hrs.

30-31 hrs.

If, in this program, course credit has already been used towards

another degree additional electives in area of specialization will

be required.

The courses in this program have been designed to make future expansion

into a minor or major program, or other programs into highly, specialized

areas, possible. This is illustrated by means of the attached flow chart.

10' ?

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---

SENATE COIO4fl'I'EE ON UNDERGRADUATE STUDIES

?

NEW COURSE

PROPOSAL FORM

Departftteflt:Bt008l_Sciences

1.

Calendar

Abbreviation Code: BISC

?

course Number:

Information

?

311 - Credit Hours:

?

Vector: 30

Title of Course:

?

introduction to Environmental Toxicology

Calendar Description of Course; A course intended to

give

the student a general

understanding of environmental toxicology with in-depth treatment of the toxic

effects of a few

representative examples.

An opportunity

is given

for students with varying backgrounds to up-date their

knowledge of basic ecological, physiological and biochemical processes.

Nature of Course Lecture and tutorial /seminar

Prerequisites (or special instructions):

Completion of

at least 60 semester

hours credit in the biological sciences program,

or permission of the Department.

What course

(courses),

it

any, is being dropped from the calenda:

Lf this course is

approved: None.

2.

Scheduling

How frequently will the course be offered? once per year

Semester

in which the course will first be offered?

Which of

your present

faculty would be available to make the proposed offering

possible?

Dr. C. Van

N"tten

0

3.

objectives of the Course

To introduce the student to the many interacting factors important In the field of

environmental toxicology, and to illustrate Its scope and atpllcatton to present

day environmental problems.

4.

Budgetary and Space Requirements (for information only)

What additional resources will be required in the following areabi

.

see memorandtinr

28 May 1980, M. Mackauer

to J. Wehstr.

Faculty

Staff

Library

Audio Visual

Space

Equipment

. Approval

?

1J85

Date:

\

,cCUS

73-34b/ (When completin

g

this form, for instructions se

---

I ?

S

.

?

K

Course Description and Outlines

(New or Modified

Courses)

BISC. (311). ?

Introduction to Environmental Toxicology.

This course intends to

,

give the student a general understanding

of environmental toxicology with in depth treatment of

the toxic effects of a few representative examples.

In this course an opportunity is given for the student

with varying backgrounds to update their knowledge of

basic ecological, physiological and biochemical processes.

Prerequisites: 60 semester hours in the biological science

program or permission of the department.

1.

heavy Metals (example lead)

2.

Hydrocarbons and halogenated hydrocarbons (PCB's)

3.

Dust, smoke and other air contaminants (asbestos)

.

?

4. ?

Food additives (artificial sweeteners)

5.

Food contaminants (aflatcxin)

6.

Common drugs (Birth control pills)

7.

Electro-magnetic radiation (x-rays)

Each of the above examples shown in brackets will be systematically investigated

under the headings shown.

a.

historical background

b.

Environmental sources and distribution

C.

Absorption

- ?

skin, ?

lungs. ?

('1

tract.

d.

distribution

e.

excretion

f.

plancental

and milk transfer

g.

toxicological effects

i.

Cencral toxicity

-

?

(metabollic, neurological

immunological, ?

endocrine

reproductive, behavioural, etc.)

ii.

t1utagefliCity

iii.

Teratogenicity

iv.

Carcinogenicity

V.

Synergistic and

antagonistic effects

?

• 8. ?

Toxic effects (cancer)

?

9. ?

Screening procedures and tests for carcinogens and other hazardous

chemicals in the environment.

It)

---

.11

List of reference

material ?

for BISC.

311 -3,

?

Introduction

?

to Environmental

Toxicology.

General Reference

Pharmacology

Goodman L. S.

and Gilman A.

?

The Pharmacological

Basis of Therapeutics 5th edition.

Physiology

Guyton, ?

A.

?

C.

1976. ?

Textbook of Medical Physiology.

5th edition.

W. B. Saunders Company.

Biochemistry

?

Lehninger, A. L.

Worth Publishers,

Stryer, L. 1975.

Ecology

?

Woodwell, George,

ecological cycles

1975. Biochemistry 2nd. Edition.

Inc.

Biochemistry, Freeman.

H. 1967. Toxic Substances and

Scientific American, March 1907

Specific Reference Material

Lead ?

Gilfillan, S. C. 1965. Lead Poisoning and the fall of

Rome. Journal of Occupational Medicine. 7, 53-00.

Hammond, P. B. 1977. Exposure of humans to lead.

Annual Review of Pharmacology and Toxicology. 17:

197-214.

Heavy Metals

?

Bresnic

?

E. Biological and Pharmacological effects

General ?

of metal catamiflafltS. Symposium. Federation

Proceedings. Vol. 37, No. 1 Jan. 1978. p.

l5-40.

Halogenated ?

Back, K. C. 1977. Toxicology of llaloa[kanc Propel [ants

Hydrocarbons

?

and Fire Extinguishants. Annual Review of l'hariiiacoloily

and Toxicology. 17: 83-95.

Taylor, C. J. IV, et al. 1970. Cardiac Toxicity of

Aerosol Propellants. The Journal of the American

Medical Association. Vol. 214, No. 1 P. 81-8.

Courtney, K. D. 1977. Prenatal Effects of herbicides:

Evaluation by the Prenatal Development Index. Archives

of Environmental Contamination and Toxicology. Vol.

No. 1

?

1977;

Wilson, IL C. and Cheng, II. II.

?

1978. ?

Fate of 2, 4-I)

in a Naff Si I t Loani So I .

Journal

of Environmental

Quality Vol. 7, No. 2, 1978.

I

---

S

ox in

?

In I •iiid , .\

?

I' ?

and Kend i ,

?

.

?

I ) 7L ..',

?

, 7,s

r;ich It. Pod I hen ;:e - p- d i ?

I

n tn v

i )

11

Ill( ?

t a I unit tami

molt . ?

1 a r ?

probe. ?

.

?

-.

?

' ?

t..'d

I

?

V(l I

N'. ?

I ?

, ?

'.1 (11

?

24 11

Was" oiii , .1 . S. , lEt if, .1 . F. , ail

lop ricitu , N .

?

197 ?

A review of the genetic. loxi co logy of Chlorinated

I) i hen zo-p-1)ioxins .

?

Mutation Research,

1 17.

?

14 I -1 (()

lhi't l Smoke Singlial , R. L. 1978. Environmental pharmacology of-'

the lung. Symposium. Federation Proceedings. Vol.

37, No. 11, 2479-2509.

Kite-Young, Kang. et al .

?

1979.

?

I. 1ects of

!\.h)('stIIs

;iiul

?

Re ty ii

i urn oil release of Alveolar Macrophage En zyinus

Archives of Environmental Health. May/.June, 1979.

p. 133-140.

(;ilihs, U. W.

?

1979. ?

Etiology of Pleural Calcification:

A Study of Quebec Chrysotilc Asbestos Miners and Millers.

Archives of Environmental Health. March/April, 1979,

76 - 82.

I'CR's ?

Edwards, R., et al. 1971. The polychlorinated

biphennyls, their occurrence and sirnificance: a

review. Chemistry and Industry. Nov. 20. pp. 1340-

134 8.

I

S

Arti ficial

SWC(' tClit.' 15

All a tox ill

MR

Takesumi Yoshimura and Masato lluda. 1978. Growth of

school children with polychlorinated biphenyl poisoning

or Yusho. Environmental Research 17, 416-425.

Sweatinan , T. W. and Renwi ck , A. C.

?

1979. Saccharin

metabolism and tumori gcni city. Science Vol . 205, 1019.

The Search for sweetness. 1975. Nut

rI

tmu and Food

Science. No. 38.

Eniodi , A.

?

1978.

?

IlyI itol , its p rope rtics and 100(1

appi i cations.

?

Food Technology, -Jan. 1978.

.Searle, C. U. Chemical Carcinogens ACS. Monograph

I 73 . A. C. S. 1976.

?

PP• 662-689

Cardiovascular Risks and Oral Cont racCilt

i V('S

?

the ?

Lancet May 19, 1979.

An tunes et a 1 . , 1979.

Endoinet ri a I Cancer arid Est roger)

use. ?

New Engi . J. of Medicine.

?

No.

I , 9-13.

•

---

Rothman, R. .J., and Lorick, C. 1978.

Oral

Contraceptives and Birth Defects. New.

J. Lied.

?

No. 10, 522-524.

X-rays Swartz, 11. M., and Reichling, B. A. 1978.

Uazards of radiation exposure

for

pregnant

women. JAMA Vol. 239, No. 18, pp. 1907-1908.

Moskowitz, M. 1978. Mammography in medical

practise.

,JAMA Vol.

240, No. 17, p. 1898.

Cancer

?

Cairns, J. 1978. Cancer: Science and Society.

W.H. Freeman.. San Francisco.

Screening Tests

?

Ilushon, J. M. et al. 1979. Tiered testing for

chemical hazard assessment. Inv. Science and

Technology 1202-1207.

Devoret, R. 1979. Bacterial tests for potential

carceflogeilesi

S

,Scient i fic American. Vol.

241-No. 2.

p. 40-49.

S

1)

---

SENATL

COMZlliTF1 '.'

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NEW. COURSE PROPOSAL

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Title

of

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1ii'ni:t

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i

Calendar Description

of

CourI: ?

liin;.:Iill

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and at iuouiher

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determining tin cnlutos ii Ion of natulzliut

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of

Course

Lec t nit ;tiid

I uto r

i

a

Prerequisites (or special

thstructLOr.$);

(:HEM J'- t,;rt.!IM

?

I I

?

II' ?

e,

What course (courses) , if

any ,

?

ug

dtopp'J I rotn

the ajendar if thi

s

c:ot'i ie t.

approved:

None

2.

Scheduling

how

frequently will the

course

be t

i

t i

e

x

ed ?

II! ?

yt;I

r

tkpeittS

u1)I!

Semester in

wRliL'

the course will

fir

,t be ufterd

Which of your present faculty would be available

1.0

make the proposed offering

5

poasihl(? S .K . i.,ower • .1 .M. D' Atiri a,

?

.

s!trwnl . T.N Be II

3.

Ob

iecLives of the Course

?

'tic

ob

ui

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hi;

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to develop

an

understand] r

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the natural enVirOflITlent h;;ed on uar t

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organic, inorganic

and physlea

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Application

u ?

thc

tic

prinei pI;

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problem:; will be

explored.

Thin

course is a

requ I

remdll( ut th

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Dipi

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pi-(wt-a ll: iii FIO

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4.

Bud

g

etar

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and Space Requirements

(for

ln;'niiatiOfl only)

What additional resources will be

required In

the following

areas:

Faculty

Staff

Library

Audio Visual

?

NONE

Space

Equipment

5. Approval

?

Date:

S

­

iv

Department Ch

?

Dc

?

jrn4t ?

'

scus

73-34b:-

(When completing this form,

ttr nsruL.o')s

bet

Memorandum

Attach

course outline).

---

I,

>

z'OPiSEI' C)Ji1. 1NY)A'CION FOR CHENIiTk

y

371

JUL5

content.

eEview ?

1

of basic

?

i1.2ls

?

etq, thual

potefltidi

and

qu1i[iiurn. Acid- bae quitir1a, bu

?

Carbon dioxide in

solution. (6 1.cturs)

2.

112.

Ind dissolution. oxides, hydroxides, and

carbonates; ?ffcts of poIynorphisI and solid solution formation.

Th- phase rule, binary and ternary phase diaqrams.

Kinetics of.

dissolution.

(4

lectures)

J. Mt

?

infl

?

n ?

soluflQf. Coordination with water,

?

hydrolysis,

hydroxo-metal complex. Ch

?

lates,

organic complexes

in natural waters, oxidatioflrelUCtlOfl. (3

lectures)

. Surfaces

and co1ids. Natur;4

Of thc solid-solution

interface;

surface tension and adsorption, the lctric double layer.

Colloids and 'hir stability, particle

iggloieration. Ion

.'xchange.

Surface chemistry of

natural solids. (2

lectures)

s.

?

?

of natural waters. Chemical

?

weatherr.q of mineral substances;

tit)il1ty

regions of solid

phas's. D'talled

examination

of carbonate and silicate systems.

,eachjnq of soils. SeaWdter. fEect of organisms on waters.

(3 lectures)

u.

?

Natural jolids.

Clay

4ui

r

ir3ls and

soils. Ma.jwas and

their

crystalliZattOn

proiucts; ntarnorphism. (3 lectures)

0

7. m

?

2_s2_h. ComposOn i:i1 strUctu

?

of

the atmosphere;

optical properties; particilat constituents. Residence time and

circulation.

Photochemistry

of atmos

p

heric constituents and

pollutants. (5 lectures)

•

?

?

2fl!! qt ibe

environment.Natural radioactivity.

?

Interactions of ionizing radiation with matter. Dosimetry.

Nan-mad sources of radioactivity. (3 lectures)

.

c ?

of nvironaentj

o ?

Environmental

aspects of energy conversion; :ntro uction to trophic analysis;

Sources and sinks of natural and industrial

pollutants. Dynamics

of enviroaneflal change.

(5 lectures)

10.

?

?

vonmenta]. rnonjtorin. Survey of methods of trace substance

?

anal

ysis.

in soil, water, :and air. Limits

of

detection,

biological

indicators. (2 lectures)

11 . (

aS p

stU.

SoL'?Ct Cd

-mc

piLS,

following a single

substance ?

through ?

- s entir ?

nvironr'ntal cycle. (Student project)

lBS

---

.

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411:

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BAILEY R, CLAHKk ET AL: "Chmis

?

- t th

?

nviroflt"

Acad.ic Pr-

a

ss,

I7r - ?

- ? -

?

This t9xt 3ervs

i ?

ti ?

t

i cours ?

t

InSe1diL

p olytechnic Institz:l.

13RODINE,

HaLcOUrtBraCe,

VIRGINIA:

"Rad

k

ctCt1

15

?

!.

?

2il2fl"

-

EDWARDS, JOHN: "cQ!b2i. ?

n! ?

2.

Ann Arbor, 19m

vtJJST, ?

., HUNTER 1:

0ekkr, 1171

(;AHILS

a N, CHRIST C: '

?

iU101iL

?

Pui1ibria"

A1dj;on-Wl'y,

KEEII, G W: "flflfl'j

?

iI

Dekker, 1978

MASTERS, i;ILUFRT: "I

?

2 ?

on ?

?

!U1!fl.A

e and

Wiley, 137L4

?

TD1'4

MJH

PANTELL,

Wiley,

R H:

?

"TChfl9!

196

?

01:, ?

!2ii±..

Tr)

170.

KRAUSKOPF, K: "Introductio 'o ;eoch

?

iistr' f

NcGraw-11iI-----

-

h

?

-

NOOHE, JOHN

&

ELIZABETH:

"Fri

vi

r

onmentai 12Y"

Academic Press, H7h

?

. ?

QD31. 2 M63

UI)(JM, tIUWAH[) ?

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0

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McGraw-HUT, i7

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introduction

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;INArF CO1MLtTiI. ON

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(JUL tS

N I'4 COUKS. P kOPOFOR?4

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CEOCRAflY

Departmsi'( :

M.I.r.VI st Ion C41ds ;jj

?

C)Ur.t

Niiiither : 319

?

Credit )Iour:

?

3

?

Vector

Title

of

Course:

isiind.0

tk.cf1ption of Cour&:

?

The course will review and analyse those

physical

processes in the environment that can be itsed to predict the dispersion

of toxic:

agents :r..

N.AtIlLS

Of

Course

?

Lecture: laboratory

Prerequisites (or special instructions): Geog. 111-3

Whjt Louts. (courses), if any, is b.ing dropped from the calendar if this course i

approved:

%St!1wLLnA

((ow frequently will

the

course be offered? 1 in 6

• Smest.r In which the course will first be offered?

Which of your

present

faculty would

be

available to make

the

proposed offering

possible? CBC, FFC, EJH, III, MCR, RES

•ObjectLvSS

of the Course

To provide a solid grounding in the basic dispersal

and precipitating mechanisms that operate in air, water and land. A major

aim will be to demonstrate the capability of predicting (toxic) material

transport and dispersion within and between the three media.

4. fluilgetary and Space k.gutrsmente (for information only)

What additional resources will be required in

the

following areas:

Faculty ?

None

I,

Staff

Library

Audi" Visual

II

Space

Equipment

S. Approval

?

Date:

O

4(4 d

Department Chairman

?

Dean

21

A

?

MJ65

Chafii, sCUS

---

:H

Simon Fraser University ?

Geography 319

Department of Geography, ?

x, y & z

Course Outline

ydcal Interactions in the Environment

Introduction ?

The course tLeats .onceptua1. and empirical knowledge of

the

physical processes in the transportation, storage and dispersal of materials

through, in and between air, water and land.

Schedule

?

One 2 hour lecture each week, one 2 hour lab. which will include

discussion of relevant topics and exercises. There will be at least one

one-day field trip.

Grades Based on lab. o'

?

(20%), an essay (40%) and a final examinatioi

i

(40Z).

Weekly themes

Week] (Lecture) 1. courseoverview: The nature and the role of the air-land-

water system in toxic material transfer.

Intro, to the Atmosphere: component and bulk properties:

stability of the atmosphere. Sources, residence time and

( ?

sinks of contaminant material.

Lab.(L) ?

Discuss weekly arrangements etc.

Week 2

?

1. The General C

4

rculatlon of the Atmosphere: the drive

and geodetic constraints; concepts of scale.

Role of moisture in the Atinos.: energy and change

ot phase; global (and local) sources of moisture and

preferred sinks.

L.

?

Geographical distributions: time--averaged vertical and

horizontal motion.

Week

3 ?

1. Turbulence in the atmosphere - the diffusion mechanism.

L. ?

Space-time distribs.: diffusion from point, linear and

creal sources.

Week

4

?

1. The real-world horizontal transport of diffusing matter -

advect ion.

Summary- atmospheric dispersal through case reviews.

Modified real cas" - Acid rain.

Wk '

?

??

1 .

?

I' • i-uni ?

I

water: ?

similar r-1 ,

d

i

fferent modes.

L.

.

22

---

Geogr.&phy :319

?

Course Outline,

Week 6 Lecture 1. Erosive and deposidonal process: general

Intro, to the Oceanic environment

L.

Week 7 Lecture 1. ...the lake scene:

Surface and ground waters

L.

Week 8 Lecture 1. Concentration and dispersion of contaminants by water

Summary...

Week 9 Lecture 1. The Air/Water/Land system - interlinked and dependent process

•

?

Intro, the nature of hard and soft rock environments

L.

Week 10 Lecture 1. Transfer process and storage in the geologic sphere: In

the hard-rock environment

L.

Week 11 Lecture 1. The soft-rock mode

Summary - contaminant flow in the regolitli

Week 12 Lecture 1. The nature of the vegetative interbody.

Absorption, concentration and/or dissipation of toxic ntueri.;ds

by vegetation.

L.

Week 13 Lecture 1. Review of process role and Intensity, in and between

t}o'

three major media.

L. ?

Open.

t

23

---

I

?

- ?

I

Course Outline

Geography 319

Text: No suitable text available

jns : From prepared notes; selected portions of reserve texts, xerox

material, "stack' journal articles and from Government sponsored research reports.

Reserve: Meteovjl2ZX Barry & ChorleY

Oke

Pasquill

Nunn

Peterson

A.W. &

C -

Boundary Layer Climates

Atmos, Diffusion

Biomet. methods

Intro, to Met.

Gregory, K.J. 6 Walling, D.E. 1973, Drainage basin

form and process, Arnold, London, 456 pp.

r, H., 1978, Groundwater Hydrology. McGraw Hill,

p,ouwe

0 ?

LLi;t of 'current' articles from: AtmoS. Environments (PergamOn), Boundary-Layer

Air, Soil Pollution (Raidel), J. Water Pollution Control,

Meteorology (Perg.), Water

Water Research Bull. Water Research, J. of Environmental Quality, Science.

Nature...

to oe

assembled.

24

---

Sj,1ti:,;I-:IUiVIITV ?

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24

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?

(.15L1 .i):.l. 1k

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?

: ?

Biological

Sciences

?

- _Cinrc

v:istwr:

BISC 650 ?

—1

•iit'i:

?

Industrial Toxicology

This course

will

give a detailed overview, and study the toxic effects of the

'! ' crmrnirrs

in -areyruvt5 prerTlt

. +n -

the

?

ra...ast -è.e

?

- -.

industrial activity

of

the h

(I

I.

'L,iii :

?

rt:I

?

te(! ?

U

?

riy: BISC 311

Note:

Av;iilable for credit to .Sc. and Ph.

1

). students in Biological Sciences

?

on the

recommendation of the $-upervlsory Committee.

2.

F'0'.L-;I:T

MD SCEDt'T4JC:

EiitLrnttl

ruroiltent: _15 -

20 When

ti itl the cotirio

first ho

o1?eT:_____

once each year

ol ei ?

11 the course hi off ered

. JUsT1r1CtT3ON:

see attached sheet

1111111 ?

IIIIITII

....IIIiI_

?

TIIi

4.

?

ESOl'(iS:

Which Fact'ltj neither will normally

teach the cours

?

?

See meindum dated

28 May 1980 from

bfliat arc the

budgetary

inp1ira(ons of vviintlng the cournc' ?

M. Mackauer to J. Webster_

Are there

sufficient

Llbrny

?

i"fi'ir -

e

?

(ppcod

(lLMlt): See library

evaluation, Suimmary

appended.

Appended: a)

a)

?

Outline

of ?

tli ?

(our'e

(Appendix

?

III)

b)

?

An indication of

?

the ec çot-me

of ?

the )nciilty nibcr

to gi ve

?

the 'or%e

c) ?

Library

renurce:

-.

.......... - ............... . - . --. -----.

..-.

'S

Approved:

Departwk'ntnl

Crrduntr Stilidies Corimi I tee'

?

,i_.__

Date:.

Faculty

?

Crnctw.tt

?

.

tt

ic:. ?

(:n

?

(lit: ?

-

late:

L

11.1t1

i'iit Ly/

adoat,

2?

Si

•

s,;iIi

?

Stu,i

•

- --

PcI c

.

---

.

Justification

?

BISC 650 Industrial Toxicology

This course is one of the core courses for the industrial toxicology option of

the proposed extended studies diploma program in environmental toxicology, and

is designed to address problems derived from toxins of industrial origin.

As no similar course is available at Canadian universities, many science

graduates, presently employed in the public and private sector who have already

obtained credit for the course "Introduction to Environmental Toxicology"

have expressed great interest in extending their training at SPU in industrial

toxicology at the graduate level.

S

---

BISC

650

?

Industrial Toxicology

?

is

The purpose of this course is to give a detailed overview

of the major contaminants and waste products present in

the environment due to the industrial activity of the

human population.

All elements, compounds or classes of compounds will be

systematically investigated tinder the following headings:

a.

Historical background

b.

Environmental sources and distribution

c.

Absorption - skin, lungs, GI tract.

d.

Distribution

e.

Excretion

f.

Placental and milk transfer

g.

Toxicological effects

i.

General toxicity - metabolic, neurological,

immunological, endocrine, reproductive, behavioural, etc.

ii.

Mutagenicity

iii.

Teratogenicity

iv. Carcinogenicity

v.

Synergistic and antagonistic effects

1. Heavy metals:

mercury

cadmium

nickel

selenium, etc.

.

2. Hydrocarbons: ?

oil spills, etc.

3.

Halogenated hydrocarbons: aerosols

PBB' s

dioxin, etc.

4.

Air contaminants: Oxides of carbon

Oxides of sulphur

Oxides of nitrogen

Dust

Smoke

Vapours

5.

Electro-magnetic radiation: high voltage transmission

radar

microwave

nuclear

Suggested text: Toxicology, The Basic Science of Poisons.

L. Casarett and J. Doull. MacMillan, 1975.

0

---

.

Selected articles for BISC 650, Industrial Toxicology.

Bresnick, E. 1978. Biological and Pharamcalogical effects of metal

contaminants Symposium. Fed. Proc. Vol. 37, No. 1.

Kingsley, K. 1977. Polybrominated biphenyls (PBB) environmental contamination

in Michigan. 1973-1976. Env. Research 13, 47-93.

Poland, A., and Kende, A. 1976. 2,3,7,8,-Tetrachlorodibenzo-p-dioxin:

environmental contamination and molecular probe. Fed. Proc. Vol. 35, No. 12.

Miller, K. 1979. The effects of Asbestos on macrophages. CRC Critical

reviews in Toxicology. 319-355.

Carter, L. 1979. Uncontrolled SO Emissions bring Acid Rain. Science

Vol. 204.

?

2

Cleveland, W. 1979. Photochemical air pollution in Northeast United States.

Science Vol. 204, 1273.

Singhal, R. 1978. Environmental pharmacology of the lung. Symposium Fed.

Proc. Vol. 37, No. 11.

Marino, A. 1978. High Voltage Lines. Environment, Vol. 20, No. 9.

Health aspects of radio frequency and microwave radiation exposure, part 1.

Health and Welfare Canada. 1977.

Savage, J. 1979. Chromosomal aberrations at very low radiation dose

rates. Nature Vol. 277.

Carter, L. 1978. Uranium Mill Failings: Congress addresses a long-neglected

problem. Science Vol. 202, 191-195.

S

27

---

• •.-

?

-- ?

'I

•I i

t

.------.—.--•-.-.-.—•.---.--•.----•---

A course designed to investigate those toxic compounds in the environment

•

?

which are

added

to contaminate, or supplement one's diet.

?

t?()

if

?

iy:!S!l_....;

Note: Available for credit to fl.Sc. and Ph.D. students in Biological Sciences

?

on the ?

-

• recommendation of the Supervisory Committee.

2.

/412 SCHI:L'LJNC.:

)st

iP1tc'1

FnroJlL.(nt_

?

20 — When will th(' course first he

flo: of ten ui) 1. the course be offered' ?

once each year

3.

JIJSTI

FTCAT) o,% , :

see attached sheet

4.

RESOI'P.(:ES:

Which raculty

member will normally teach

Lite

courst:__•_

?

Se

memoranm dated

__

28 May 1980 from

What are the budgetary

implications of uitintng the courr.e:

M. Mackauer

-

Are there

i.utficient

Library

I.ttI,ec';

(ppencl deLailti):p_

.

library

evaluation, summary

- ?

appended.

Ap1wiukd:

?

i)

Outline of the Ciir;e

?

(Appendix III)

b)

An indication of the rt w p otcll,e

of the Vacuity meubcr to give

the c ou r se

•

c)

Library re.sourc:

'

?

Departmental Graduate

Cyst

ir

Cr u.s

I s ! I

lid

s

?

(flI;

hi

ti

...................

Mile

S,n:tI

• ?

liii c

Si

WOVill

) ?

(:/.l:•D.°.: ?

J':IO!:•.lrI0

Biological

S_ .____ _______ •

__C0IItfi( iihc

.

r: BISC 651 -

-

?

and Dru

g

Toxicology

---

.

Justification

?

BISC 651 Food & Drug Toxicology

This course is one of the core courses for the food and drug toxicology option

of the proposed extended studies diploma program in environmental toxicology,

and is designed to Investigate those toxic compounds which are added to, con-

taminate, or supplement one's diet. No similar courses are available at

Canadian universities, forcing science graduates, employed in the public and

private sector, to enrol in courses offered by universities in the United

States, at great expense of time and money.

.

0

---

BISC. 651

?

Food and Drug Toxicology

?

.

0

This course will investigate those toxic compounds in

the environment which are added to, contaminate, or

supplement one's diet.

All compounds or classes of compounds will be systematically

investigated under the following headings:

a.

Historical background

b.

Environmental sources and distribution

c.

Absorption - skin, lungs, GI tract

d. Distribution

e. Excretion

f.

Placental and milk transfer

g.

Toxicological effects

i.

General toxicity - metabolic, neurological,

immunological, endocrine, reproductive, behavioural, etc.

ii.

Mutagenicity

iii.

Teratogenicity

iv. Carcinogenicity

v.

Synergistic and antagonistic effects

1. Food additives: colouring agents

preservatives

aritificial sweeteners

particulate matter

2.

Food contaminants: plant and animal toxins

bacterial and fungal toxins

industrial toxins

3.

Common drugs: vitamins

analgesics

sleeping pills

anti-depressants

stimulants

artificial hormones

psychoactive drugs

Suggested text: Toxicology, The Basic Science of Poisons. L. Casarett

and J. Doull. MacMillan, 1975.

Selected reference material

BISC. 651, Food and Drug Toxicology

S

S

30

---

Khera, S. K. 1979. A review of the specifications

and toxicity of synthetic food colors permitted

in Canada. CRC Critical Reviews in Toxicology,

Vol. 6, No. 2, 81-134.

Dietary Fiber. Food Technology. 1979.

Brody, A. 1977. Impact of external influences on

food packaging. CRC. Critical Reviews in Food

Science and Nutrition.

Dimsen, N. 1975. Toxicology and regulation of

Natural Colors. Food Technology 40.

Hay, A. 1978. Neurotoxins may go unrecognized.

Nature, Vol. 274.

Berry, L. J. 1977. Bacterial Toxins. CRC.

Critical Reviews in Toxicology, Nov. 1977.

Ruggiere, G. 1976.

Vol. 194.

Wieland, T. 1978.

. and Antamanide: the

Poisonous Amanita N

Toxicology, Vol. 5,

Drugs from the Sea. Science,

Amatoxins, Phallotoxins Phallolysin

Biological Active Components of

Llshrooms. CRC. Critical Review in

No. 3.

Vorhees, C. et al., 1979. Psychotropic Drugs As

Behavioural Teratogens. Science,

?

205. 1220-1225.

Johnson, F. C. 1978. The Antoxidant Vitamins.

CRC. Critical Reviews in Toxicology. Vol. 11, No. 3.

Jacobs, B. L., and Trulson, H. E. 1979. Mecha-

nism of Action of LSD. American Scientist, Vol. 67.

I

3'

---

(:/%l.I:NW.l 1! IO!:fl6TJ0

-- ___•____Cotire

l:t,t.thcr:

BISC 652

Tit!(' ?

Problem Analysis in Environmental Toxicology

Ihcrinti';i: ?

A course designed to provide the student with practical experience

of th idTlT8

Iê .

?

-

?

1-1-6 ?

gisc 650

C.di i :u1.;:

?

V:.c:

rrrct1t?(:) if :iygISc 651 or

?

permission of the Department.

?

0

2.

E:OLL:l:T KR

I

O SCF!1L'LTNC:

Estirnited Enrol ltoent:_ 15 - 20 When will the course first he offered:______

once each year

llo of ten

vi

11. the course be off

çred:

3.

JIJSTJFIC/iTION:

see attached sheet

4.

RES)t'RCfS:

Which Faculty member will

normally teach

the

course:

?

-

Seememorandum date?

What are the budgetary

$ffip1i(atiOfls

of tiiitntiug the cot'rr.e:_

28 May 1980 from

Are there sufficient Library r.'.ource'; (append teaih):

See

library

evaluation. SumElary

appended.

Appended: a)

Outline of

the C.nir;e

?

.

?

(Appendix ill)

b)

An indication of

the cou'ctcnre of

the Faculty mei;i,er to give

the

course.

c)

Library

resnurCe

Approved:

Departmental Gr'diiate Studies

FaciiI ty Gradis

?

nil

I ...

:011

ItA

tc

:

_

_. ?

l)atc:_

•Fncu

1 Y

:_ _

?

-... ?

.- __.__• __hat.e

:jL

Seus:uI ' Crad

ate

t ud (..; C;ui

tte ?

.....

.-____

flatr

Pat

C.

-

I ?

Sesu:uI.:

---

Justification ?

BISC 652 Problem Analysis in

Environmental Toxicology

This course is one of the core courses for the proposed extended studies

diploma program in environmental toxicology, and is designed to provide

practical experience in advanced laboratory and field methods currently

used to monitor toxic agents in the environment. This proposed course

will provide practical backup for the industrial, and food and drug toxi-

cology options described earlier.

.

.

33

---

.

BISC 652-3

?

Problem Analysis in Environmental Toxicology

A practical course in environmental toxicology. Specific

environmental problems will be analyzed in depth at the

theoretical as well as the practical level using the most

advanced techniques available.

Environmental problems specific to the students' area of interest will be

selected and subjected to a detailed Investigation, including problem

identification, sampling methods, application of appropriate biological and

chemical analytical techniques, data evaluation, and integration with the realm

of environmental toxicology in order to generate the appropriate data base for

the design of possible recommendations.

Suggested texts and reference material:

?

-

Environmental Impact Data Book. Golden, Quellette, Saari and Cheremisinoff.

Ann Arbor Science, 1979.

Instrumental Methods of Analysis. Willard, Merritt and Dean. 5th ed.

Van Nostrand Company, 1974.

Methods in Immunology. Campbell, Garvey Cremer, Sussdorf 3rd ed. W. A.

Benjamin, Inc. New York 1977.

Work, T. S., and Work, E. 1979. Laboratory Techniques in Biochemistry

and Molecular Biology. Vol. 7.

Knoll, G. F. 1979. Radiation detection and Measurement. John Wiley.

---

S

Course Descriptions

(lxistinp Courses)

131St'. 405

?

Cell Physiology

The physiology of cells with emphasis on the Physical and

chemical natures of specialized activities.

B [Sc

?

329 ?

Jut

roduct ion to Ixper I inenta I Techniques.

This course is designed to introduce the students

to basic

measurement methods

and i nst

rument at i on as used I u inodt' ru

biology.

BISC. ?

432

Chemical Pesticides and the Environment.

the properties, uses, modes of action, and good and bad

consequences of the use of chemicals to prevent or control

pest damage and plant diseases.

J1s(;.

?

846

Insecticide Chemistry and Toxicology

.

The chemistry of insecticides, with emphasis on their

toxicology, metabolism and fate in the environment.

CHEPI. ?

357

Chemical and Instrumental Methods of Identification of

Organic Compounds.

Basic principles of infrared, ultraviolet, nuclear magnetic

resonance and mass spectroscopy as applied to the identification

of organic compounds.

dIEM. ?

416

Modern Methods of Analytical Chemistry

• instrumentation, techniques and scope of application of

analytical methods based on optical properties, electrochemical

phenomena and interphase separations.

?

Applications to problems

in pure and applied chemistry and biochemistry.

---

A

Appendix 1

?

36. ?

- a

The Follow i r ?

iii

ioniii

t

ioo was gathered, Ly mean:; ;

?

1 w:.t.

I

on;t

irc.

and personal cummunicitjon, from students enrolled in a pilot

course iii LEvi

i'onnu.ntal Toxicology, BISC. 172

?

VV.

?

4-all ,

1978.

ii

Credit students ?

36

Audit students ?

4

Special audit students

?

8

Total enrollment ?

48

i!yPe of Students

Undergraduates

?

21

Graduate and MR.

?

4

Other ?

23

Ilic 23 students belonging to the last group were made up out of

such

representatives

as:

from various industrial and government aencics

?

-0

- Department of Health and Welfare

- Ministry of the Environment

-- Municipality of Burnaby

- ILC.M.P.

- B. C. Hydro

- hospitals

- ILC.J.T.

- Labour Movement

- Environmental consulting companies

- Pest control companies

- Government laboratories.

I

Most, if not, all, of these representatives possessed a B.Sc. and

often h I glier degrees, including Ph.D.'s (3)

'Ihe

FCUSOI1S

for taLing this course are the same as those already

outlined in the introduction of this proposal.

Many

government i"Hid

industrial agercie are presently being contacted

and their response to the proposed proprain will be compiled in the

near future. ?

S

---

37.

S

?

Aj)pen,li x 1 ,

?

I1II1

Enrollment

chRracterIS ic

?

f flC. 472, Sehcted Topics in Invirflnmeflt%I

Toxicology, Fall, 1979.

l:ipIIre

for

iir. 472

9

Fail

1979

are

.

shown for

comparison.

Enrollment

?

Iall, 1078

?

Pail,

?

1979

Credit Students

?

52

4 ?

3 ?

Audit

8 ?

17 ?

Special Audit

Total Enrollment

Type

of

Student

Undergraduates

?

21 ?

35

4 ?

3 ?

Graduate

Other

Students

23 ?

34

The 34 students belongin

p

to the last group were representatives from:

. ?

- B.C.I.T.

- B.C. Hydro

- Can-Test Ltd.

- City Analyst Laboratory (Coroners Lab)

- City of Vancouver, Health Department

- Environmental Consulting Companies

- G.V.R.D., Parks Department

- Health and Welfare Canada

- HacHhllan and Bloedel

- National Water Research Institute

• - Provincial Health Ministry

- R.C.H.P., Crime Detection 1.ah

- Vancouver General Hospital

- Workers' Compensation Board.

2rd

---

is

38.

Appendix If

July 12, 1979.

Or. Paul B. Hammond,

Professor of P.nvironmental Health,

University of Cincinnati, Medical Center,

3223

Eden

Avenue,

Cincinnati, Ohio 45267,

U • S. A.

pear Sir,

I am in the process of preparing a report on the feasability

of starting a program in environmental toxicology

at Simon Fraser

University. It is

i'ny understanding that you

are the director of

the toxicology training program which is available at the University

of Cincinnati. Consequently in that capacity, could you provide me

with some helpful information. The questions I have

at this time

are as follows:-

- What are the projected requirenents for

individuals with

training in environmental toxicology

by government

and

industry both at the B.Sc. and the Ph.D.levels?

- What is the student demand for training in this area and

what is their background?

- If my information is correct the

University of Cincinnati

also offers

a program in Industrial Hygiene and, although I

personally can see the need for a separate program in

toxicology, what were the original reasons for separating

those two related fields and not combining them as often

appears to be the case at other

universities?

- What other

IJniversities in the U.S.A. offer programs in

toxicology, specifically environmental toxicology?

If you could provide me with some information regarding the

above questions, I would greatly

appreciate it.

Yours sincerely.

r:. van ';etten, M.P.

CvN/lt

---

0__

3223 Eden Avenue

Cincinnati, Ohio 45267

39

I

University of Cincinnati Medical Center

INSTITUTE

OF ENVIRONMENTAL HEALTH

KETTERING LABORATORY

(513) 872-5700

August

23,

1979

Dr. C.

van Netten

Department of Biological Sciences

Simon Fraser University

Burnaby, B.C. ,- Canada VSA lS6

Dear Dr. van Netterl,

I must apologize for the unseemly delay in responding to your letter

of July 12. Hopefully, this will still be of use to you.

In answer to your first question, there are no reliable projections

as to the demand for toxicologists.

A

couple years ago I served as co-

chairman of a committee which attempted to evaluate the supply-demand

situation in a number of environmental health disciplines including toxico-

logy. We

really were unable

to make any definitive estimate as to demand

. ?

for

toxicologists.

I can only tell you that the placement service of the

Society of Toxicology has been unable to provide enough

qualified applicants

to satisfy the

needs

of poteI4titi employers. I enclosed one summary of our

studies concerning supply and dzind.

In connection with your first question, however, I would like to offer

a personal opinion concerning the demand for B.Sc.'s in toxicology. I do

not feel there is much

demand for this type of graduate. What would he do?

I suspect he would operate at the level of technical assistant on research

projects.

His

background would likely be rather diffuse. It seems to me

that research assistants do not need to know very much about environmental

issues and concepts to serve effectively in this capacity.

1 am not sure that I understand your second question, but I suppose you

want to know how much interest students have in the field. If that is what

you mean, I can tell you that I receive more than 100 inquiries concerning

our program. Most of these students have or are receiving baccalaureate de-

grees in chemistry, biology, or a combination thereof.'

In regard to your third question, the distinction between industrial

hygiene and toxicology seems quite clear to us. The emphasis in industrial

hygiene is on the monitoring and control of exposure to toxic sub-stances.

The

focus in toxicology is on the toxic effects of exposure to chemical

substances. The industrial hygiene students are required to take a single

course in toxicology. It is a survey course which deals with the principles

of toxicology, tie methods used in the evaluation of toxicity and some

.

r)ç

it)

---

Di. C. van Nettfl

August.

23,

1979

Page 2

?

.

3gb

examples of toxic i:robiem

,

.y. heavy metal , ;ases and vapors and economi

poisons (rodenticid ç

s, insecticides, herbicides).

Your question concerning other programs in environmental toxicology

cannot be answered with assurance as to completeness. I know that the Uni-

versity of California, Davis offers a B.S. degree in toxicology. I know of

no other such programs. At

the

graduate level, the major programs I know

of are at the University of

Rochester, Departments of Pharmacology and Radio-

biology, University of Texas, Department of

Pharmacology, University

of Kansas,

Department of Pharmacolo(jy, University of Tennessee, and

Purdue University,

School of Pharmacy. If you want a complete list,

I suggest that you contact

Dr. Margaret Hitchcock. She has received a contract from the National Insti-

tute of Environmental Health Sciences to undertake a continuing

survey of

supply and demand in the area of toxicology. Her address is:

Dr. Margaret Hitchcocc

Yale University

School of Medicine

Department of Epidemiology and !ublic Health

60 College Street

New Haven, Connecticut 06510

I enclose three items

which provide further

details regarding our toxico-

logy program:

?

1) brochure

2) course requirements

and ?

3) course descriptions.

I hope they are helpful.

Sincerely,

Paul

P

B. Hammond,

13.

D.V.M.,

/4t

.

-k

Ph.D.

Professor

of Environmental Health

PHil/rn] I

i-:nclosures

':1.0

---

I ?

S

PMfl

2

Dr. t. Widsac. Vacuity of Education

Dr. J. Dickins

o n,

gi861030gY

Dr. E. V. Roberts, L.L. & L.

New

Course

DISC 311-3

Dr. K. Mackauer. Chairman.

Dept. of Biological Sciences.

April 2, 1980.

I an

enclOsiDS

herewith a new course proposal (Introduction to

?

SnvirooaulIIt

ToxiCOlOV.

DISC 311-3) for conaid.rattofl of course overlap.

If I do not hear from you by April 18 1 will

aesuas

that there is

no overlap and .ubit the proposal to our Vacuity Undergraduate Curriculum

CoittSe.

K. Nackau.r.

MK/ms

End.

L]

4

---

SIMON FRASER UNIVERSITY

?

MEMORANDUM

........

Siib 1

ccl

?

NW

(:uI$c i'roI

m;;I

I

RISC 311, 422, 650, 651, 652.

Datc

I thought you might wish to have copies of the attached memoranda

?

from Sheila Roberts, Secretary of the Faculty of Arts Curriculum Committee.

Copies

of the above course proposals were sent.to the Faculty of Arts,

Education and Interdisciplinary Studies for consideration of course

overlap. Please note that I asked for a reply by 18 April, failing that,

I.

WO(Il(l

assume the absence of overlap. A reply was received only from the

Faculty of Arts, and EducatiO1.

?

.

I ?

(

(/

'

Cckauer. ?

. ...

MN/nis ? .

Enc l..

.. ?

'•,j'-.

---

S.,

•pine.nt. ,q.

Subject.

..

s

.c:

?

.?2

From...

3el

.

14

RlTt ?

Cetary

.u1t.Y.

p..Mt...

.

rcw çtc.

Date.....

.

ay21

,

190

.....................

...........

D ?

IiVI'L'

J

I

IIrL,I.

?

' 1*

MEMORANDUM

The Faculty of

Arts

Curriculum Committee at its meeting of May

8,

1980,

considered..11

and

1

422 in terms of )verlap and found no substantial.

overlap with the courses offered in the Faculty of At-

fs

.&L aA— ,

)Q&

S. Roberts

c.c.

H.M.

Evans

SR/md

S

/

P1ii2

1^1

---

MEMORANDUM

A.G. Sherwood, Chairman

?

From ?

Marvin Wideen

Undergraduat

e

Programs

Faculty

of

Science U.C.C.

?

Faculty of Education

ubject

?

NEW COURSE CHEM. 371-3

?

Date ?

February 2th, 19%

Ii

Please be advised that there is no overlap between the

P

roposed course, Chem. 371-3 - Chemistry and the Environment

and any offered in the Faculty of Education.

Marvin Wideen

Undergraduate Programs

Faculty of Education

MW: vs

?

is

.

£1

---

SIMON FRASER

UIN1VEKUIY

?

3

MEMORANDUM

..r.

?

ja,C1t1,

To ....... Dr. j.M.Webste

.

.

?

.............. ...... .From ....

Dean of Science.

Subject. ?

wtrPiiiOM.. .tQXiCQ

J

,Q g

Y. Jg.gpt.....

Dept. of Biological Sciences.

?

Date .....

KAY

.28,.19?O.................................

My

earlier

submission for Faculty of Science approval of a proposal

leading to a Minor and E.S.D. in Environmental Toxicology did not address

the question of resources required for mounting the Program.

The Program Incorporates some existing as well as the following 6 new

courses:

RISC 311-3

?

introduction to Environmental Toxicology (Vector 3-1-0)

CHEM 371

?

Chemistry of the Environment - 1

?

(3-0-1.)

GEOG 319

?

Physical Interactions in the Environment (2-0-2)

BISC 650

?

Industrial Toxicology

?

(3-1-0)

BISC 651

?

Food and Drug Toxicology

?

(3-1-0)

RISC 652

?

Problem Analysis in Environmental

?

(1-1-6)

Toxicology

. ?

All BISC courses are proposed to be offered once a year, CHEM 371 will

be offered once a year or as needed, and GEOC 319

will be offered once in

2 years. The CHEM and GEOG courses can be mounted without additional resources,

at this stage, according to tü.tr Department submissions.

However, the 4 new BISC courses will require additional resources, both

in faculty as well as some equipment. The main requirements are the following.

2 new Faculty positions, one at the Assistant Professor level and one

at the Assistant/Associate Professor level

$50,000 Capital funds to set

up

RISC 652.

Justification

All core courses will be offered once a year to enable students to

complete their program in a reasonable period of time. Assuming that Faculty

hold the tutorials in the upper levels courses, though not necessarily in the

lover level RISC 311, the total number of faculty contact hours generated by

the new courses is 16 hrs per annum, which is equivalent to 1-1/2 faculty

workloads. The remaining 1/2 faculty position is needed for program co-ordina-

tion and liaison with industry.

As there will be considerable start-up work in developing the new courses

and in particular in setting up and testing laboratory exercises for BISC 652.

both Faculty

positions

should be established as

early as possible,

that

is,

as soon as we receive UCEC approval. In the absence of

such approval inclusive

of approval for the

new

positions the Department will not be able to offer

the Progam.

./2

---

-2-

l)i.

.1. M.

Webster, ?

May 28, 1980.

Re: Environmental Toxic l2

Ido not anticipate any additional requirements for staff (excepting

(TAs as Justified by enrolments), AV, space, or equipment (excepting the

(uftia]. cost of equipping BISC 652 and the usual annual operating costs in

materials and supplies or minor equipment). However, it may be desirable

at a later time to provide technical support through LI-Is rather than

through GTAs.

?

.

?

&

Ma èkauer

MM/ms

cc C. van Netten

?

C. L. Kemp

R. C. Brooke

—0

L)

---

1MJ1"1 r

hJ%F.fl ui'i i' r4nt I.

•

MEMORANDUM ?

l'" '

To ?

PrQ.A..S.hrWQOd ........... ......

?

From ...........

.........einstin

......acv.l.ty..of.

Science. .U.C,C..

Subject ............

New. Course. .CHEM. .37.l.3

..............Date...........

80/031.1

I...............................

This is to confirm that library resources are,adequate to

support new course CHEM

371-3,

as stated on the new course

proposal form.

S

ah

4 r.;

---

Eva1uaon of Library Rsou:ces

in S

upp

o

rt cf

?

Environmrtal Toxicolc'iy

as dscribed in a

'Proposal for a Minor and an Extended S

tu

d-

- ,?

s Di

p

loma Program

?

in Envircnmental Toxicology'

?

by

Dr. C. van NEtten

?

Bicicgical Sciences

?

2 October

1979

.

-.

Maurice Deutsch

24 February 1980

?

Library

5incn Fraser University

raf 4 ?

copy ?

#2

^.8 0

---

Th1c of Contc..ts

P

u:pOse . . . . . . . . . . . . . . . . , , . • • • • • • .1

Tbc-

ProgrIID . . . . . . . . . . . .

?

. . . . . . . . • . . .1

Tb .

? Library's Collct1cnS . . . . . . . . . . . • .. . ?

. .

2

Books and

Monographs . . . . . . . . . .. . . . . . . . .2

Bock Candi lates Published in 1

58C . . . . . . . . . .4

Book candidates Published in 1979 . . . . . . . . . .4

Book Cariidates publisheJ in 1978 . . .. . . . • . .5

Book candidates Publshd

an

n

1977

Earlier . . . .7

Journals

3nd pricdicals . . . . . . . . . . . . . . . .8

Journal

Candidates Not Available

lfl B.C.. . . . . .

.8

Journal

Candidates Available

in B.C.. . . . . . . . 10

Indexes. Abstracts, and Caline Computer

Searches . . . 11

Summary . . . . . . . . . . . . . . . . . . . . . . . . . 13

.

?

ii

4;9

---

Purpose

The purpo ?

cf

his r- port is to uinarize tn' Lib:ary's

hook and noncqraph, jcu:nal, arid inx and abst:act

ccll

v

?ctions with a view to supportinq 3 new and 2 modifiel

ccurses and

1 h a

p:oposd program in Er.v1.ronant3l

Toxicology.

The Program

The fcllcwinq

n

o

w

cr modified courses are proposed for the

Environmerta 1. Tox icoloqy Prcqram:

New Courses

-

?

Introduction to Environmntil Toxicology,

Bisc

L$XX

Undrqraduate;

-

?

Industrial

Toxicoicqy, Bsc 5xz

Graduate;

-

?

Food and Drug

Toxicology, Disc

5xx,*

Graduate;

Modified Ccurses

-

?

Evironmntal

Chemistry, Chem 3xx, Undergraduate;

- ?

Physical Interactions in the Environment,

Geog

4XX,k

Undergraduate.

Other courses required

by this program ara already offered

by the Biology, C)emisry, and

Geography

Departments and

are

curr

e

ntly supported ty the Library.

Thcsc Colt rS('S Ilav(' Subsequently been designated RISC 311-3, RI SC 050-3,

RI.(: 051 -3, CIIIM 371-3 and (;IOC 319-3 respectively.

---

P

2

The Library's Collections

Lc2.

rcr cor.vr.iece ?

relevant po:ticns of the book and

mcr.oqraph collect icn

(rfrerce works, t'?xtbook

S,

trtiJes,

har:dbooks, gcve:rmeiit publications, proceiings of symposia,

ccnfer€ncs, ccr.qresses, etc.)

hive been

arranged in the

fcllowinq I broad

subject

areis outlined below. This

r c pre.s*nts approximately 12,745 volumes in suppert of the

nw proqraw and the 5 poposd courscs. The 500 volume

tcxlcoloqy subst (A1lO - RAl270)

will

probably

become cri

ct th most ipr,rtar.t and

useful

parts of the hcck

ccllEctiofl fcr

students in this

projrim.

- ?

Hy'lrolcgy and Hydrosciences; Phy3ic21 Geclogy, Farth

Surface, Landforms, Geomorphology; Surface and

Und e rqround Water; Oceans, Lakes, Rivers, Estuaries;

Snow, Ic c

,

Glacirs, Prnafro3t

.

;

R

c

mcte

Sensing

* GB7 - GC1580 ?

2200 v.'

- ?

Meteoroicqy, Climate,

Weather

I QC851 - QC98 ?

1200

V.

- ?

Geoloay, Mineraicqy, Petrology, Dynamic and Structural

G'ology

• ?

QE1 - QE654

?

5150 v.

- ?

Biogeography; marine, Freshwater, arid Brackish Water

Biology, Ecolcgy,

and Pollution

$ QH83 - QH199 ?

730 v.

-

Ecology; Ecicgical R

e

search, Interactions,

IntorrElatioLEhis: Environmental Chemistry, Pollution,

Contamination; Bios-Geos Interactions

* QU5

1

40

-

Q115145

?

1

730 v

-

?

FnvircLmn'al Health, Medicine, Hygiene, Quality,

Hazards, Safety, Contamirar.ts, Pollutants (Air, Soil,

Water)

I RA565 - RA591

?

100

V.

-

?

Toxicology; Toxic Effects

of Pesticides, Food Additives,

Smoke

,

and Smoking, Drugs, organic and Inorganic

Chemicals (Man-made or Natural), Noise, Radioactve

Substances, etc.

I hA1190 - iAl270

?

500 v.

1

ApprxiP.at

q

number cf volumes.

si

---

3

- ?

fl:Qust:ial ?

icire and IIyqjn;

0CCUptOa1 DiSeaS'S

#

ic63 -

RC967

?

35 v.

- ?

pharmacology

I QP 903 - QP981, PM ?

500

V.

E -

EnvironmEntal Mcr.itoriflq, ChenistLy, IrAstrunentatiCfl,

and Engineering; Treatment of all Aspects of Polluted

Env 4

rOflmrLt3; Environmental Assessments and Studies

* TD5 -

TD94

?

1500 v.

Online

information retrieval systems prcvida a modern,

fficier.t and expedient means' of obtaininy titles cf books,

reference works, journals, proceedings of

conferences,

symposia, etc., from machine readable card catalogs and

icurnals' lists produced byCISTI (Canada institute for

Scientific and Technical Information, previously known as

the Naticnal. Science Library) and the

HIM (U.S.

National

Library cf Medicine).

CPN/OLE (Cdnada/Oflhifle Enquiry System, Ottawa) and

MEDLINE (Medical Infcrmation Online, Bethesda. Maryland),

two government supported information retrieval systems, warp

used to search CISTI's card catalog (OON) and the

HIM's

card

catalog (CATLINE) for took material received since January

1 q

78. Searches were

keyed into a terminal located on

the

fifth ficor cf the

Library

and connected

to remote

computers

by telephone accessil:16 data communications networks

(DATAPAC and TELENET). Printouts

of the retrieved citations

were wailed to the Library and

were received in

about a

week. The fcllowing subjects were searched:

food, drug', perfume, and cosmetics tcxicology;

tcxicology of

substances;

environmental

industrial an

diseases, and

envl rcnwental

intEractiOflS.

other organic and inorganic

toxicology and

environmental diseases;

d occupational hygiene, medicine,

tcxico logy;

chemistry

and environmental

The bcok and monograph collecti)fl can adequately

unport the proposed courses and the proposed prcgram.

Weaknesses occur in such areas as:

- ?

industrial and occupational diseases, medicine,

hy qene;

---

a

4

- ?

liu.Dfl trtit,

?

ni: ?

::fl'j, dnd

tcho1cqy;

-

?

f-,cl al.1 flavor science

and 'cnology;

-

?

drugs a

r

id pharmacy;

-

p.-^rfumo

and cosmetics science and

'

t

e

chnology.

The

Library's chief means of obtaining science books

nd

aor.cgraphs, an applicaticr. of computerized inform

a

tion

rE'rieval to

took

selection and

distribution,

is throuqh

the

spcification of a ccmp:hensiVe set of subject headinqs (a

prc file cf interest) designed and used by BNA (Blackwell

Ncrth

America) Book Agents. Th BNA profile ensures that

English

language

material

in apprcpriate areas of the life

and physical sciences i

nd most ar-as cf tcxicolcqy will be

receivEd automatically by the Library.

A list of suggested book purchases (titles cnly for the

sake

of brevity) foll3ws; arrangement is by publication

date.

Rook Cand1dates

Published

in

Dvelcrmnts in Occupational Medicine.

Book Candidat

.

tj Publshei

in iB

Advances in PestiLe Scienca: Plenary Lectures

Presented at the Fourth Interntational Congress

of Pesticide Chemistry, Zurich, Switzerland,

July 24-28, 1978.

Aquatic ioxicology: Proceedings of the Second Annual

?

Symposium on Aquatic Toxicology: A symposium

Sponsored By ASIM Committee E-35 on Pesticide,

Clev e

land, Ohio,

31 Oct. -

1

Nov. 1977.

Controversial Chemicals: A Cit1zn's Guide.

Current AFprOCheS to Occupational Medicine.

Forensic Tcxicolcgy: Controlled Substances and

Dangerous Drugs.

Fundawen315 of Indu3rial Hygiene.

Hazardous and Toxic Effects of Industrial Chemicals.

S

53

---

5

Halth EffCtS of Ha1oqe:at:1 Aromatic Hydrocarbons.

L'cture Nct's or occupational Medicine.

TLVS: Threshold Limit Values for Ch

c

nical suts'ances

in workroom Air Adopted by ACGIH for 1979.

Toxicology.

Toxicology and occupational Medicine.

Eook CanlidateS Published in 1978

Asbestos and Disease.

Canadian occupational Safety and Health Law.

Cancer and chemicals.

Cadmium studies in Japan:

A Review.

Chemicals and Agriculture:

Problems

and

Alternatives; proceedings of a Seminar Held.at

Echo Vall

q

y Centre, Fort Qu'Appelle,

Saskatchewan, November 3 and 4

0

1977.

clinical Toxicology Manual.

The Diseases of Occupations.

Distribution of Trace Elements Related to the

Occurrence

of Certain Cancers, Cardiovascular

Diseases,

and

Urolithiasis.

Factors Influencing Metabolism and Toxicity of

Metals: Proceedings of an

International Workshcp

meeting organized by the Scientific Committee cn

The icxicology of Metals of the Permanent

Commission and international AssociatiCfl on

occupational Health: Stockholm, July 17-22,

1977.

Fluorocarbons, An Industrial

Hygiene Survey of

Worker Exposure in

Four

Facilities.

Folk Name and Trade DiseaSeS.

Haiards of MdiCatiOfl: A Manual on Drug

Interactions, Contraindications, and Adverse

Reactions with Other Prescribing and Drug

Information. ?

i.

-

---

I ?

*

b ?

-.

Health of Women

At

work.

HepatOtoxiCitY:

The Adverse Effects of Drugs and

other Chemicals on the Liver.

Industrial and Environmental XenobiotiCs: In Vitro

versus In Vivo Siotr3nsfOrmatcfl and Toxicity:

proceednqS of an International Conference Held

in Prague, Czechoslovakia, 13-15 September nil.

MthCdOlCqiCal Approaches to Deriving Environmental

and occupatiCral Health Standards.

NIOSH Puilicatiors Catalog.

occupational

Haalt. and Safety Conc

e

pts: Chemical

and processing Hazards.

occupational Health as Human Ecolcgy.

Patty's Industrial Hygiene and Toxicology.

Pharmacological Methods in ToxicoiCqy.

Phosphorus

in

the Environment: Its Chemistry and

• ? Biochemistry.

Principles of

EcotcxcOlOgY.

proceedinqs of the Zirst International Congress on

Toxicology.

Solvents, Adhesives, and Aerosols: proceedings of a

Seminar Held in Torcnto in May, 177, by the

Ontario ministry of Industry and Tourism in

Cooperation With the Addiction Research

PcUn dation.

sympcsluix on the Handling of Toxicological

informatiCfl.

The Third Advanced Course in Industrial loxicoloqy.

Underwater PhysicloqY.

Work Capatility and Physiological Effects in He-02

Excursions tc Pressures of 400-8001200 and 1600

Feet of Sea Water.

0

---

Book Candidates Futlished in 177 and EaLlij

Analytical Tozicolcjy Methods Manual.

Chemical MutagGnE.

Chemistry in

the

Natural World.

Conference on Women and the workplace, June 17-19,

1976, Washington, D.C.: Proceedings.

Electron Microsccpy and X-Ray Applications to

Environmental and Occupational Health Analysis.

Environment and Resource Management: Presented at

27th Canadian Chemical Engineering Ccnference,

Calgary, Alberta.

?

(23-27 Oct. Hi?)

Environmental. Chemistry.

Environmental Toxicology.

The Evaluation of Toxicological Data for the

Prot.ction of Public health,

Guidebook, Toxic Substances Control Act.

Guidelines for Analytical

Toxicoicqy Program.

Industrial Health.

Information Sourcebook: Cccupational Safety and

Health.

International Directory of Applied Research for the

Protection of Man at Work,

introducticn to Ecological

Biochemistry.

Lead.

Occupational Health and Safety.

Occupational Health in Canada: Current Status.

p

roce.dings, Workshop on Behavioral Toxicology.

Trace Metals in Urban Aerosols.

p

ermi5sflle L.?v€ls of Toxic Substar.cs in the

Working Environment.

7

.

---

Jcurnals

and PeriodiCal3

The

Uflifl

List

of Scientific Serials in Canadian

Libraries

(ULSSCL,

part of the CAN/OLE System) , a daatase

of more

than 43,000 jouznals and

annuals

held by 248

Canadian libraries, and

CATLINE

were searched online for

jcurnal titles in the followinq broad areas:

- ?

tcxicology

-

?

industrial hygiene

The following list of 28 possible journal and

supplement

acquisitions

is divided in two groups, those

already available in

B.C.

and those not available in the

province. Subscription prices are those found in Ulrich's

International Periodicals Directcry, 18th

ed.,

1979-1980

(P.R. Bowker, N.Y., 1979).

p

rices are in U.S. dollars. An

asterisk indicates estimated average cost based on the 1978

average price of medical periodicals reported in Library

Jcurnal, July 1978, pp. 1356-1361. Formula used to

calculate estimated current price is:

((((57 .06z0. 112) +57.06)

zO.

112) +63. 45) =70.55

( ( (7 C. 15*0. 15) +7 C. 55) *0. 1) .8 1. 13=89.

214

0

?

rcunded to $90.00.

Jour ?

Candidates

Not

Availae in B.C.

Advances in Modern

Toxicology.

Archives cf Tcxicclocjy.

Archives Cf Toxicology.

Supplement.

hejcal-tOXicOlCgiCal Series,

Bulletin.

Clinical 'roxicolcqy Bulletin.

Current Topics in Environmeltal

and

TcxicOlOgical

Chemistry.

DvelcpaefltS

in 'toxicology and

Environmental

science.

* 90.00

$ 234.00

* 90.00

* 90.00

• 90.00

* 90.00

* 90.00

ki

Environmental

Mutgen Society. Newsletter.

?

* 90.00

European Society cf

ToxicCiOqy.

proceedings.

?

* 90.00

5I'

---

S

Haza:dcus an1 To xic Subs'ace.s.

*

9C.00

Hl'h, ?

sfy

?

and

?

Education.

*

90.00

1ct.rrAatiCnl

?

Jc''irn1 ?

of ?

Ci::iC.31

PhatLacicJY, ?

Therapy

?

and Toxicolcyy.

*

C.0O

Jourrl ?

ef Aralyticil TcxicolCy.

$

30.00

JouLnl cf Envircflm?fltal Pthclojy anI

Toxicoloqy.

$

33.00

Journal ?

cf ToxicciOgiCal Scier.cS.

*

90.00

Journal of

!nvircnmantal

Sciences and

Health. ?

Part C:

?

Environmental Health

Scienc3.

$

14t4.00

Modern

PharmacolC9yTOXiCCl0gY.

*

90.00

NeurOtcXicology.

$

60.00

p?sticide ?

and Toxic Chem.

-cal,

?

Ncws.

?

- $

200.00

Progress in TcxicolOgy.

*

90.00

Revi

?

vs

?

in Biochemical Toxicology.

*

90.00

Toxic Sutstnces.

?

(National Institute for

occupational Safety

?

and Health).

*

90.00

Toxicological European Research.

?

Recherche

europ'er1fle ?

en tcxiccloqie.

*

90.00

Toxicology.

$ 208.00

Tcxicology Annual.

* 90.00

Toxicology Letters.

* 90.00

¶OX-TIPS.

$

25.00

veter1nay ?

u.d Human Toxicololy.

S

---

V

10

Journal

?

Can1idatES Available

?

in B.C.

Clinical

?

TcxiCOlCJy.

82.50

Drug and cheic3l Toxicology.

$

40.00

European

EnVironmEntal

Jou

r

nal cf

Hyq.€fle.

Toxicology and

* 90.00

journal cf

Irdustril Hygiene

and

*

30.00

tcxicology.

journal

cf Toxicology and Environmental

$

58.50

H Ealth.

Modern Trends in Toxicology.

• 90.00

Toxicological and

Environmental Chemistry

*

90.00

REVIEWS.

ToxicDfl.

Toxicology).

?

(International

Society on

$

108.00

---

11

Tndex ?

Abs-ractsL and Online Coutr Searches

The real ky to the published literature in the life

sciences is the index and abstract collection. Below is a

list of indexes and abstracts which the Library subscribes

tc and which provide access to environmental and

cxcological citaticr.s in journals, society publications,

proceedings cf corferences, symposia, congresses, etc.,

technical and research reports, Ph.D.

dissertations,

gcvrnmettal publications, and evan

plannedard ongoing

rEsearch projects.

-

?

Biological Abstracts and Biclogica], Abstracts/RRN

- ?

British Cclumtia Government Publications Monthly

Checklist

-

?

Chemical Abstracts

- ?

Current Contents -

a.

Agr1cultur, Biology and Environmental Sciences

b. Life Sciences

c. Physical and Chemical Sciences

-

?

Dissertation Abstracts International

- ?

Envircnment Index and Abstracts

- ?

Excerpta Medica

-

?

Geo Abstracts

-

?

Government Reports Announcmnts (NTIS)

- ?

Index Nedicus

-

?

i€tecrcicgica.l and Geoastrophysicl Abstracts

- ?

Monthly Catalog cf Canadian Gcvernment Publications

-

?

monthly Catalcg ct United Stites Government Publications

-

?

Psticdes Abstracts

- ?

Pollution Abstracts

- ?

Scier.c€ Citation Index

bu

---

12

- ?

l€

?

.d ?

rr Psci:ces Abt:

The only omssicn is 'h.

Bibliojzaphy and Index of

G .

cioqy, a publicaiCn which provides access to many aspcs

of environmenal int'ractiofls. This itiex would cost about

$1,000 per ya:.

Each of the above printed indexes,

excluding

Mecrolcqical and

GecastrophysiCal

Abst:acts, is accessible

online frcm differ

.

nt commercial and government Subsidizdd

systems in Canada and the U.S. and can be searched by temcte

terminal from the Library.

1

As a quid.?, a typical srch

consis t

ing of one database and about 40 printed references

averages about $15.

In additicn to the above,

there

are two outstanding

online databases cne of which, TOXLIMF, has no printed

equivalent,

and one nct

e

worthy, convnticna1ly printed drug

and toxicoloqy reference work which is

it

its 17th edition:

- ?

1QJJNE, 1966- , is one of the most valuable toxicology

databases consisting of references and citations

selected from 11 indexes (8 of which are still currently

published) rather than from the original literature.

Provide access to information about naturally occurring

and man made crgartic, inorganic, and radioactive

chemicals, drugs, pesticides, pollutants, food

additives, cosmetics, etc.

Registry Cf Toxic Effects of ghemical Substances is

available in both ardcopy and cnline. Provides access

to documental toxicity data for 36,851 substances,

accessible by 125,000 names, and includes threshold

limit values, recommended standards in air, aquatic

toxicity data, CA registry numbers (for about 20,000

substances) , LD50, molecular formulas, synonyms, toxic

effect, rcutes, crgan affected, etc. Prepared by the

U.S. National Institute for Occupatcnal Safety and

Health (NIOS1fl.

Martilil

.A

r ?

is an outstanding

thorcughIy comprehensive a

?

encycicpedic compilation of

infcrmaticn (including tcxicologlcal) about drugs,

pharmaceuticals, cosmetics, crams, loticns, as well as

organic atd inorganic chemicals used in their

'two sparate booklets ara attached describing online

literatir sea:ching in Life Sciences, and Phys±cal Sciences

and Technology at the SFEJ Library.

.

6i.

---

'3

pro paticr..

/ ?

Summary

The Icurnal collection may need to be

strer.gthened

depending on the activity and growth 3f the anticipated

program ar.i the speed

with

which artic].s are needed.

The most sensible approach at

this time

is to watch the

develcpw€nt of this new p:oqzam and enlarge the

coll€cticn if and when a demand for additional material

arises.

tnt€rlibrary Loans can usually obtain books and

photocopi e

s of articles not available at SF0 from UBC in

about five to ten days. Interlibrary Loans is currently

t c

stinq an online crdering

system

(part of CAN/OLE) for

books and journal photoccpies not

available in

B.C. from

CISTI in Cttawa. So far response time has teen qocd,

about ten to twenty

days.

62

---

4

• p

?

SiMON FRASER UNIVERSITY

MEMORANDUM

To

.............. Mr....Har.y...Evans,..etary ......................

?

From ..... .

Sheila Roberts, Secretary

Senate Committee on

?

Faculty of Arts Curriculum Committee

.............

Ura

.te...

?

Dean of Arts

NEW COURSE PROPOSAL -

Subject .... PEP ?

n

..NT ...

Q

?

QcRAPH ?

....*

....................

?

Date .........

.198O-O4-.16

The new course proposal from the Department of Geography listed below has been

approved by the Faculty of Arts Curriculum Committee at its meeting of April 10,

1980.

As the Faculty of Science Curriculum Committee is also involved in examining

various course proposals which will become part of the Toxicology Program,

I would suggest that you check with them before putting this course on the

agenda of SCUS.

Thank you.

.

?

S. Roberts

SR/md

Attachments;

GEOG. 319-3, Physical Interactions in the Environment

c.c.Dr. C. Van Netten, Biological Sciences

Dr. D. R. Birch, Assoc. Vice-President, Academic

APR 171980 ?

REc

7

1

.'5 OFFICE

MAIL DESK

63

---

SIMON FRASER UNIVERSITY ?

MEMORANDUM

The tparbrnt of Geography approved a new course proposal at its

departrrental committee meeting Thursday, January 31, 1980. The

title of the proposed course is "Physical Interactions in the

Environment" and its suggested course nuirber is Geography 319-3.

This course will be integrated into the proposed EnvixonnEntal

Toxicology

Program which, in turn, will becaiE a part of the Extended

Studies Diploma Program.

As the Faculty of Science Curriculum. Committee will be involved in

examining various course proposals which will also become part of

the

Toxicology

Program, I would suggest that faculty coordination

would be helpful.

AA.,4j0L&LL

L4Lt

co: Dr. C. Van Netten, Biological Sciences

Secretary, Faculty of Science Curriculum (bninittee

OFFICE OF THE DEAN

FEB-6t

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F

ACULTY OF ARTS

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