SiMON FRASER UNIVERSITY
?
.
MEMORANDUM
Senate
From. ?
...qf.
qa
•
4iate Studies
SubIed.9
U
...
.ç ?
Changes ..Qr
of Chemistry
Date .........
November ?
I.
1986
.
Action undertaken by the Senate Graduate Studies Committee,
at its Meeting on November 10, 1986, gives rise to the, following
motion:
MOTION:
"That Senate approve and recommend approval to the
Board of Governors, as set forth in
S.86-88
the proposed changes in the Department of Chemistry:
Delete: Chem 851-3
Chem 852-3
Chem 853-3
Chem 854-3
Chem 855-3
Stereochemistry
Physical Organic Chemistry
Modern Synthetic Techniques in Organic
Chemistry
Chemistry of Natural Products
Biosynthesis of Natural Products
Add:
?
Chem 750-3 Advanced Organic Chemistry I
Chem 751-3 Advanced
.
Organic
'Chemistry II
Chem 752-3 Bio-Organic Chemistry
Chem 753-3 Photo-Organic Chemistry
Chem 754-3 Carbohydrate Chemistry"
Rationale for these changes is attached.
B.P. Clayman
Dean of Graduate Studies.
O ?
.mm/
attach.
S
To: Dr. B. Clayman,
Dean of Graduate Studies,
Chairman of the Senate Committee
on Graduate Studies
Subject: Curriculum Changes
Ftart
G. Geen, Dean
Dean of Science
Date: October 6, 1986
SIMON FRASER UNIVERSITY
?
MEMORANDUM
.
Please find attached the documentation related to the Curriculum Changes to the Graduate
Program of the departments of: Chemistry, Mathematics and Statistics , and Physics. These
Curriculum Changes were approved by the Faculty of Science Graduate Studie s Committee and
by the Faculty of Science.
I would appreciate it very much if you would place these items on the Agenda of the next Senate
Graduate Studies Committe for consideration and approval.
a)
"To approve the new Course proposal for STAT 650-5 : Quantitative
Analysis In Resource Management and Field Biology as contained In
paper FSC 86-7 ".
?
Jb)
?
'70
approve the Changes In the Graduate Course Offering of the Chemistry
Department as contained In the paper FSC 86-8."
?
c) ?
'70
approve the new graduate course PHYS 875-3: Advanced Nuclear
Physics (PAPER :FSC 86-9)."
Thank you.
-::-•
?
cc: ?
Dr. A. R. Freedman, Chairman Faculty of Science Graduate Studies Committee,
Chairman Department of Mathematics and Statistics.
Dr.C. H. W. Jones, Chairman Department of Chemistry.
Dr. J. C. Irwin, Chairman Department of Physics.
SiMON FRASER UNIVERSITY
1%cc
MEMORANDUM
Fculty
a
Graduate Studies Committee
To
...................................................
Faculty of Science
........ Propsed
Change in
Chniitry ........
Organic Graduate Cose
Subiect
......................
.....................
ur s
F. W. B. Einstein, Chair
From.....
Dept: Crdnte"Progr
?
tn•te.
Department of Chemis
September 16, 1986
?
F0 -- ------
Date
....
.
SEP7•7J••
OF?
OFFiCE
We suggest
changes
to the
Chemistry graduate courses, in the area of"
chemistry,
as detailed below.
Delete
CHEM
851-3
(Stereochemistry)
CHEM
852-3
(Physical Organic Chemistry)
CHEM
853-3
(Modern Synthetic Techniques in Organic Chemistry)
CHEM
854-3
(Chemistry of Natural Products)
CHEM855-3
(Biosynthesis of Natural Products)
Add
CHEM
750-3
(Advanced Organic Chemistry I)
CHEM
751-3
(Advanced Organic Chemistry II)
CHEM
752-3
(Bio-Organic Chemistry)
CHEM
753-3
(Photo-Organic Chemistry)
CHEM
754-3
(Carbohydrate Chemistry)
It is proposed that the organic graduate courses consist of 750-3 - 754-3
inclusive and CHEM 856-3 (Selected Topics in Organic Chemistry).
Scheduling
CHEM 750-3 and 751-3 will be offered regularly in the Fall or Spring. They will
be the courses of choice for entering graduate students in organic chemistry and
could also serve as core courses for chemists enrolled in a graduate chemistry
program.
CHEM 752, 753 and 856 will be offered regularly, in organized fashion to suit
demand.
Rationale for the Change
1.
The new course, 750, fulfills the need for an organic course accessible to
all chemists enrolled in a graduate chemistry program.
2.
The new course, 751, fulfills the need for a second organic course acces-
sible to students specializing in organic chemistry. This will ensure that
an organic graduate student receives a solid training in all fundamental
aspects of organic chemistry. The combination of 750 and 751 in one course
is not feasible owing to the extensive nature of the material to be
presented.
3.
The deletion of old courses, 851, 852 and 853 would avoid duplication of
material presented in 750 and 751. In addition, some of the topics
presented in 852 (Physical Organic Chemistry) will now be covered in the
-2 -
core course, 860 (Advanced Physical Chemistry).
4.
The old courses 854 and 855 no longer reflect current faculty interests and -'
the new courses 752-754 accomodate current faculty interests and expertise.
5.
The selected topics course 856 allows flexibility in the organic teaching
and will be retained.
6.
The revision allows a student requiring a full 15 hours of organic graduate
work to be easily accomodated.
F. W. B. Einstein
att.
Proposed
CHEX
750-3 Advanced Organic
Chemistry
I
An advanced treatement of mechanism
and structure in organic chemistry
and the use of physical methods as
probes of structure, stereochemistry
and conformation.
CHEN
751-3 Advanced Organic
Chemistry II
An advanced treatment of strategy in
organic synthesis. The principles
and use of modern synthetic methodol-
ogy.
CHEM
752-3 Bio-organic chemistry
An advanced treatment of the use of
enzymes in organic synthesis, the use
of stable- and radio-isotopes in the
study of enzymatic processes, and the
design of enzyme inhibitors.
CHEM
753-3 Photo-Organic Chemistry
Discussion of energy transfer, elec-
tron transfer, excited states, photo
physics, and mechanistic and synthet-
ic aspects of photochemistry in solu-
tion.
CHEM
754-3 Carbohydrate Chemistry
A detailed treatment of the structure
and reactions of monosaccharides,
the use of carbohydrates as chiral
templates in organic synthesis, ad-
vances in glycoside synthesis, the
occurrence, chemistry, and conforma-
tional analysis of complex carbohy-
drates and their role in biological
systems.
CHEM
856-3 Selected Topics in Organic
Chemistry
An advanced treatment of specific
topics related to the study of
organic compounds. Topics which will
be discussed will vary from one
semester to the next.
Current
CHEM
851-3
Stereochemistry
A study of
the structure of organic mol-
ecules and reaction mechanisms with
specific references to configuration and
conformation.
CHEM
852-3 Physical Organic Chemistry
Consideration of physio-chemical aspects
related to reaction mechanisms such as
transition state theory, activation
energies, acidity scales, kinetics and
isotope effects.
CHEM
853-3 Modern Synthetic Techniques
in Organic Chemistry
Discussion of some recent and important
methods of synthesis of organic com-
pounds of applied or academic interests.
CHEM
854-3 Chemistry of Natural
?
Products
Consideration of occurrence and chem-
istry of organic compounds of natural
origin with particular emphasis devoted
to alkaloids, steroids, terpenes and
phenolics.
CHEM
855-3 Biosynthesis of Natural
Products
A detailed treatment of the mode of
biological elaboration of representative
compounds belonging to alkaloid,
terpenoid and phenolic groups.
CHEM
856-3 Selected Topics in Organic
Chemistry
An advanced treatment of specific topics
related to the study or organic com-
pounds. Topics which will be discussed
will vary from one semester to the next.
9
Approved: Departmental Graduate Studies Committee:
WPFi1e : crsprop . frni,dgsl
SIMON FRASER UNIVERSITY
New Graduate Course Pro
p osal Form
?
Form GS.8
CALENDAR INFORMATION:
Department: ?
Chemistry
?
Course Number: 750
Title: ?
Advanced Organic Chemistry I
Description: An advanced treatment of mechanism and structure in organic
chemistry and the use of physical methods as
p
robes of structure, stereochemistry
and conformation.
Credit Hours:
?
3 ?
Vector: 3-0-.0
?
Prerequisite(s) if any:
2.
ENROLLMENT AND SCHEDULING:
Estimated Enrollment: ?
8 ?
When will the course first be offered:
?
87-3
How often will the course be offered: Each Fall or Spring semester.
3.
JUSTIFICATION:
• ?
CHEM 750 fulfills the need for an organic course accessible to all chemists
enrolled in a graduate chemistry program.
4. RESOURCES:
Which Faculty member will normally teach the course:
?
Drs. Pinto or Chow
What are the budgetary implications of mounting the course: None
Yes, no additional
Are there sufficient Library sources (append details):
?
holdings are required
Appended: a) ?
Outline of the course.
b)
An indication of the competence of the Faculty member to give the
course.
c)
Library resources.
Faculty Graduate Studies Committee:
Faculty: ?
25A----
'V4t
Senate Graduate Studies Committee:
Senate:
Date:
?
O---
'VL
Date:
Date:
GS. 18/1/71
DEPARTMENT OF CHEMISTRY ?
Fall 1987
CHEM 750-3
Advanced Organic
Chemistry I
Instructor's Name: Drs. Pinto or Chow
Prerequisites:
Course Content:
?
An advanced treatment of mechanism and stucture in organic
chemistry and the use of physical methods as probes of
structure, stereochemistry and conformation.
To p
ics Included: ?
1. ?
Molecular Structure and Chemical Reactivity
2.
Isotope Effects Upon Chemical Reactions
3.
Catalysis
4.
Solvent Effects on Rates and Equilibria
5.
Principles of Stereochemistry and Conformational
Analysis.
6.
Conformational and Steric Effects on Reactivity
7.
Physical Methods as Probes of Structure,
Stereochemistry and Conformation.
8.
Aromaticity
Textbook(s): ?
"The Physical Basis of Organic Chemistry", H. Maskill,
Oxford Science Pub., 1985
"Advanced Organic Chemistry" Pt. A, Carey and Sundberg,
Plenum Press, 1984.
Faculty Com p
etence: Drs. Pinto and Chow are specialists in the above areas.
0
SIMON FRASER UNIVERSITY
?
WPFile: crsprop . frm, dgs I
New Graduate Course Pro
p osal Form
?
Form GS.8
.j. CALENDAR INFORMATION:
Department: ?
Chemistry ?
Course Number: 751
Title: ?
Advanced Organic Chemistry II
Description:
?
An advanced treatment of strategy in organic synthesis. The
p rinci p
les and use of modern synthetic methodology.
Credit Hours: 3
?
Vector: 3-0-0
?
Prerequisite(s) if any: \
2.
ENROLLMENT AND SCHEDULING:
Estimated Enrollment: ?
8
?
When will the course first be offered: 88-1
How often will the course be offered: Each Spring or Fall Semester
3. JUSTIFICATION:
CHEM 751 fulfills the need for a second course accessible to students specializing
in organic chemistr
y
. This will ensure that an organic graduate student receives
a solid training in all fundamental as
p
ects of organic chemistry.
4. RESOURCES: ?
Drs. Oehlschlager
Which Faculty member will normally teach the course:
?
or Pinto.
What are the budgetary implications of mounting the course: None
Yes. No additional
Are there sufficient Library sources (append details):
?
holdings required
Appended:
..
a)
?
Outline of the course.
b)
An indication of the competence of the Faculty member to give the
course.
c)
Library resources.
Approved: Departmental Graduate Studies Committee:
?
1rFit
/
Faculty Graduate Studies Committee:
?
Date:____________
Faculty: ?
4
?
Date:
Ii
Senate Graduate Studies Committee:\
?
Date: 1)
Senate:
?
Date: ?
_
GS.l8/l/7l
[1
DEPARTMENT OF CHEMISTRY
?
Spring 1988
CHEM 751-3 Advanced Organic Chemistry II
Instructor's Name: Drs. Oehlschlager or Pinto
Prerequisites:
Course Content: ?
An advanced treatment of strategy in organic synthesis.
The principles and use of modern synthetic methodology.
To p
ics included: ?
1.
?
Planning a synthetic Route
2.
Carbon-Carbon Bond Forming Reactions
3.
Methods of Ring Formation
4.
Electrocyclic Reactions, Sigmatropic Rearrangements
Cycloaddition and Cycloreversion Reactions
5. Normal
vs.
Reverse Reactivity
6.
Carbon-Carbon Double-Bond and Triple-Bond formation,
and Allene Formation
7.
Oxidation and Reduction Reactions
8. Protecting Groups
9. Multi-Step Syntheses
10.
Use of Organometallic reagents in organic synthesis
Textbook(s):
?
"Advanced Organic Chemistry" Pt. B, Carey and Sundberg,
Plenum Press, 1984.
Primary literature sources.
Faculty Com
p
etence: Drs. Oehlschlager and Pinto are specialists in the above
areas.
.
.
WPFi1e : crsprop. frm, dtclO
SIMON FRASER UNIVERSITY
New Graduate Course Proposal For
?
Form GS.8
. 1. CALENDAR INFORMATION:
Department: ?
Chemistry ?
Course Number: 752
Title
?
Advanced Bio-organic Chemistry
Description: An advanced treatment of the use of enz
ymes in organic synthesis,
the use of stable- and radio-isoto
p es in the study of enzymatic
p
rocesses, and the
design of enz
y me inhibitors.
Credit Hours: 3\
?
Vector: 3-0-0
?
Prerequisite(s) if any: \
2.
ENROLLMENT AND SCHEDULING:
Estimated Enrollment: ?
8 ?
When will the course first be offered: 88-3
How often will the course be offered: Once a year
?
-
3. JUSTIFICATION:
CHEM 752 allows a greater flexibility in organic teaching and accomodates current
faculty interest and expertis.
4.
RESOURCES:
Which Faculty member will normally teach the course:
?
Dr. Oehlschlager
What are the budgetary implications of mounting the course: None
Are there sufficient Library sources (append details):
?
Yes
Appended: a)
?
Outline of the course.
b)
An indication of the competence of the Faculty member to give the
course.
c)
Library resources.
Approved: Departmental Graduate Studies Committe
?
Date:
Faculty Graduate Studies Committee:
?
te:
Faculty:
___________________________________________
Senate Graduate Studies Committee:
2 ?
Date:LU
Senate:
CS .18/1/71
DEPARTMENT OF CHEMISTRY
?
LFall 1988
?
I
CHEM 752-3 Advanced Bio-organic Chemistry
Instructor's Name A. C. Oehlschlager
?
Instructor's Office:
?
C9044 ?
Prerequisites:
Course Descri
p
tion: An advanced treatment of the use of enzymes in organic
synthesis, the use of stable- and radio-isotopes in the
study of enzymatic processes, and the design of enzyme
inhibitors.
To p
ics included:
A. ?
Use of enzymes in organic synthesis
1)
Oxido reductases - specificity/active site topology/methods of
cofactor regeneration.
2)
Hydrolases - specificity, effects of solvent, active site topology.
3) Ligases.
B. ?
Use of stable- and radio-isotopes in the study of enzymatic processes.
1)
Synthesis and analysis of chiral methyl groups.
2)
Steric course and mechanism of enzymatic Claisen and Aldol
condensation.
3)
Biotin-dependent Carboxylations and enzymatic carbàxylation, of
phosphoenol -pyruvate.
4)
Pyridoxyl phosphate-dependent enzymatic reactions.
5)
Addition and elimination reactions.
6)
Stereochemis try of terpenoid biosynthesis.
7)
Stereochemistry of phosphoryl group transfer reactions.
C. ?
Design of enzyme inhibitors.
Topics in this section to be drawn from current literature relating to
design of theraputic and pesticide agents.
Faculty Com
p
etence: Dr. Oehlschlager is a specialist in the above areas.
Textbook(s): ?
Primary Literature sources
Mark Distribution:
[J
La
WPFi1e:crsprop.frm,dgsl
SIMON FRASER UNIVERSITY
New Graduate Course Pro
p
osal Form
?
Form GS.8
1.
CALENDAR INFORMATION:
Department:
?
Chemistry ?
Course Number: 753
Title:
?
Photo-organic Chemistry
Description: ?
Discussion of ener
gy
transfer, electron transfer, excited states,
p hoto p
h ysics, and mechanistic and s
ynthetic as p ects of
p
hotochemistry
in solution,
Credit Hours: 3
?
Vector: 3-0-0 ?
Prerequisite(s) if any: \
2.
ENROLLMENT AND SCHEDULING:
Estimated Enrollment: ?
8 ?
When will the course first be offered: 88-3
How often will the course be offered: Once a year
3. JUSTIFICATION:
CHEM 753 allows a greater flexibility in organic teaching and accomodates current
faculty interests and exPertise.
•:
?
RESOURCES:
Which Faculty member will normally teach the course:
?
Drs. Chow or Hill
What are the budgetary implications of mounting the course: None
Are there sufficient Library sources (append details):
?
Yes
Appended: a)
?
Outline of the course.
b)
An indication of the competence of the Faculty member to give the
course.
c)
Library resources.
Approved: Departmental Graduate Studies Committee;
Faculty Graduate Studies Committee:
Faculty:
Senate Graduate Studies Committee:
Senate:
Date:
Uàte:
Date: ?
Qc4— 1
Date:______
Date:__________
GS. 18/1/71
DEPARTMENT OF CHEMISTRY
?
LFal1 1988
CHEM 753-3
Photo-organic Chemistry
Instructor's Name: Y. L. Chow or R. Hill
?
Instructor's Office:
?
C----
?
Prerequisites:
Course Descri
p
tion: Discussion of energy transfer, electron transfer, excited
states, photophysics, and mechanistic and synthetic aspects
of photochemistry in solution.
To p
ics included:
1)
The interaction of light and matter - basic concept.
2)
Transition between two state-energy surfaces - the Franck-Condon Principle
3)
Absorption and emission spectroscopy - photophysics.
4)
Excited states - physical and chemical properties.
5)
The concept of radiationless transition.
6)
Organic photochemistry - MO theory.
7)
Mechanistic photochemistry in solution.
8)
Energy transfer - electron transfer.
9)
Synthetic applications.
Faculty Com
p
etence: Drs. Chow and Hill are specialists in the above areas.
Textbook(s): ?
Primary Literature sources
Mark Distribution:
ei
SIMON FRASER UNIVERSITY
?
WPFi1e:crsprop. frm,dgsl
New Graduate Course Pro
p osal. Form
?
Form GS.8
. 1. CALENDAR INFORMATION:
Department:
?
Chemistry ?
Course Number: 254
Title:
?
Carbohydrate Chemistry
Credit Hours: 3
?
Vector: 3-0-0
?
Prerequisite(s) if any: \
2.
ENROLLMENT AND SCHEDULING:
Estimated Enrollment: ?
8
?
When will the course first be offered: 89-1
How often will the course be offered: Once a year
3.
JUSTIFICATION:
CHEM 754 allows a greater flexibility in organic teaching and accomodates current
faculty interests and expertise.
. 4. RESOURCES:
Drs. Pinto or
Which Faculty member will normally teach the course:
?
Slessor
What are the budgetary implications of mounting the course: None
Are there sufficient Library sources (append details):
?
yes
Appended: a)
?
Outline of the course.
b)
An indication of the competence of the Faculty member to give the
course.
c)
Library resources.
Approved: Departmental Graduate Studies Committee:
Faculty Graduate Studies Committee:
Faculty:
Senate C
Date:__________
Date:
Date:
Oc- /o/I
Date: I
7
Senate:
?
-
Date:__________
CS . 18/1/71
0
DEPARTMENT OF CHEMISTRY
?
DAX,Spring 1989
CHEM 754-3 Carbohydrate Chemistry
Instructor's Name: B. M. Pinto or K. N. Slessor Instructor's Office:
?
C----
Prerequisites:
Course Descri
p
tion: A detailed treatment of the structure and reactions of
monosaccharides, the use of carbohydrates as chiral
templates in organic synthesis, advances in glycoside
synthesis, the occurrence, chemistry, and conformational
analysis of complex carbohydrates and their role in
biological systems.
To p
ics included:
1)
Structure and configuration of monosacchar ides.
2)
Stereochemistry and conformational analysis of monosaccharides.
3)
Reactions of monosaccharides.
4) Glycosylation Reactions.
5)
Use of carbohydrates as chiral templates in organic synthesis.
6)
Biosynthesis of Saccharides.
7)
Carbohydrate Antibiotics.
8)
Nucleosides and Nucleotides.
9)
Complex Carbohydrates: occurrence, chemistry and their role in biological
systems.
10)
Conformational analysis of oligosaccharides.
11)
Molecular Recognition.
Faculty Com
p
etence: Drs. Pinto and Slessor are specialists in the above areas.
Textbook(s): ?
Primary Literature sources.
Guthrie and Honeyman, "Carbohydrate Chemistry"
Sharon, "Complex Carbohydrates"
Mark Distribution:
