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SIMON FRASER UNIVERSITY
MEMORANDUM
To: Senate
?
From: Senate Committee on
Undergraduate Studies
Subject:
Department of Biological
?
Date: October 15,
1986
Sciences - Curriculum Changes
Action undertaken by the Senate Committee on Undergraduate Studies
at its
--
meeting of October 15, 1986 gives
risto
the followingmotion: ?
-
"That Senate approve and recommend approval to the Board
of Governors, as set forth in S.86-
72,
the proposed
is
?
New courses - BISC 416-3 Fish Biology
BISC 423-4 Biotechnology - Industrial
?
Applications
BISC 431-4 Molecular Biotechnology
Deletion of - BISC 421-3 Biotechnology"
Subject to the approval by Senate and the Board of Governors the Senate
Committee on Undergraduate Studies approved waiver of the normal two-
semester time lag requirement to permit first offering of BISC 416 and
B!SC 431 in Spring 87-l.
0
SIMON FRASER UNIVERSITY
?
MEMORANDUM
To: R. Heath, ?
From:
P. Dobud
Secretary to Senate
?
Administrative Assistant
to the Dean of Science
Subject: ?
Calendar Changes,
?
Date:
October 2,1986
Biological Sciences Program
This is to inform you that the Faculty of Science, in its meeting held on Monday September 29,1986
has approved the following motions with regards to calendar changes for the Biological Sciences
Program. I would appreciate it very much if you would place these items in the agenda of the next
SCUS meeting for consideration and approval.
a) —
New
urSeppdl BlSc4i6-37BlSc423-4&BISC431-4. - - - - -
--
(PAPER: FSC86-2)
To approve the following new course proposals:
BISC 416-3 Fish Biology
. (3-0-4)
An i ntroduction to the biology of fishes with an emphasis on classification, evolution,
anatomy, physiology, and ecology.
.
?
Prere q
uisites: B/SC 316, or permission of the Department.
BISC 423-4
Biotechnoloav
- Industrial Applications. (2-0-6)
The use and manipulations of microbial cultures for production and extraction of industrially
important compounds will be studied.
Prere q
uisites: BISC 303, B!SC 321 recommended.
B/SC 431-4 Molecular Biotechnolo
gy . (3-0-6)
Laboratory with accompanying lectures to give practical experience in the application of
recombinant DNA technology to basic and applied research.
Prere q
uisites: B/SC 321, or permission of instructor. Recommended B/SC 401 and! or
B/SC 402 concurrently
.
"To delete B/SC 421-3 Biotechnology from thi
Department of Biological Sciences."
cc: Dr. L.M. Srivastava, Chairman Department of Biological Sciences.
SENATE COMMITTEE ON UNDERGRADUATE STUDIES
NEW COURSE PROPOSAL FORM
Department: Biological Sciences
Credit Flours: 3
?
Vector:
i±EiiIS
1. Calendar Information
Abbreviation Code: BISC Course Number: 416
Title of Course: Fish Biology
Calendar Description of Course:
An introduction to the biology of fishes with an emphasis on classification,
evolution, anatomy, physiology, and ecology.
Nature of Course Lecture and Laboratory.
Prerequisites (or special instructions)
BISC 316, or permission of the Department.
What course (courses), if any, is being dropped from the calendar if this course is
approved: None.
2.
Scheduling
How frequently will the course be offered?
?
Biennially
Semester in which the course will first be offered? 87-1
Which of your present faculty would be available to make the proposed offering
possible?
B.A. McKeown
?
0
3.
Objectives of the Course
To develop an appreciation of the diversity of fishes with respect Ito
structure, function and ecology through lectures.
Laboratory sessions will be designed to exhibit various species in
association with different habitats as well as identification and
classification methods. Labs will also introduce students to fish
anatomy, behaviour and physiology.
4. Budgetary and Space Requirements (for information only)
What additional resources will be required in the following areas:
Faculty
Staff
Library
Audio Visual
Space
Equipment
5.
Approval
Date:
?
i,
4/October/1986
Department Chairman
?
'- ?
Dean ?
Chairman, SCUS
SCIJS 73-34b:- (Wh r ?
omDletinq this form, for
instructions
see Memorandum SCUS 73-34a.
SiMON FRASER UNIVERSITY
?
File: D5
MEMQRANIUM
?
F$ 8 -
I
0
o . .Eac.ult.y. of.
?
jegraduat.........
From.
M. Srivastava, Chairman
Cur.ric.uhmL comuiit.tee...............................Dept. of Biological Science.
Sub
jed
......CALENOAR .CHM
?
QS...........................o.??e....51.
.ate
.1 ?5..............................
The following new courses were approved at a Department Meeting held on
October 9, 1985 and now require your consideration and approval:
BISC 416-3
?
Fish Biology
BISC 423-4
?
Biotechnology - Industrial Applications
BISC 431-4 Molecular Biotechnology.
Note that the introduction of BISC 423-4 and BISC 431-4 will be coupled with
the removal of BISC 421-3 from the Department offerings.
Course proposal forms and relevant documentation are attached.
L
Lalit M. Srivastava
LMS/ms
Ends.
cc C. L. Kemp
NOV
New course pposa1 - Fish Biology - BISC 4
Rationale
The Biological Sciences Deportment historically has offered
courses on various basic aspects of life sciences such as cell biology,
genetics, developmental biology, ecology, physiology, marine biology,
microbiology, evolution, parasitology, morphology, toxicology and
pest management. The department has also emphasized experimental
techniques used in the life sciences. In comparison to other
universities, less emphasis has been devoted to plants and animals at
the organismol level. More recently, the deparment has introduced
courses on invertebrates, entomology, ornithology and mammology.
Fish represent a major and diverse group of vertebrates and a number
of faculty members in the department (Belton, Dill, Farrell, Geen,
Gross, Low, McKeown, Oloffs, Smith and Webster) use or have used
fish as experimental models in their research. Fish biology has been
offered as a special topics course five times on a more or less
biennial basis with good student enrolments. The department is
moving towards an undergraduate stream in marine biology and with
existing faculty and student interest in fish biology it is now
proposed to offer this academic area as a regular component of the
undergraduate curriculum.
Since fish biology has already been offered five times, it has been
a course that has required teaching assignments previously. If this
new course is offered on a biennial basis it would thus not require
any more teaching commitment than has been provided for in the past.
Thus, no other course(s) in the department should be required to be
dropped. This course has been offered at the Bamfield Marine Station
as well as at SFU. Museum specimens are already available at
Bamfield and are starting here at SFU. Library facilities here at SFU
as well as at Bamfield are already adequate for this course.
Lectures
A.
Classification and evolution - on introduction to what fish are and
where they live. The scope, aims and methods of classification.
The vertebrate ancestry and major groups of extinct fishes and
those represented as living forms.
B.
Form and function. Including,
1.
Integurnentary system. Including scalation, scale derivatives,
barbels, colouration, light organs and poison glands.
2.
Respiration and circulation - gill structure and function in
major fish groups. Mechanisms of gas exchange and transport in
blood. Air breathing in fishes.
3.
Swim bladders - development, structure and function. Removal
and concentration of gas from blood and by the rete mirabile.
Air bladders and sound production and reception.
o
• ?
New course proposal - Fish Biology - 6SC-4X(
4.
-Nervous system and senses - structure and function of the
central and peripheral nervous systems. Fish senses including
the lateral line system, electric organs, electromagnetic
reception, equilibrium, hearing, sight, temperature reception
and chemoreceptiori.
5.
Chemical messengers. Typical vertebrate endocrine tissues and
their hormonal elaborations. Specialized endocrine
developments in fishes such as urophysis, corpuscles of
Stannius and ultimobranchial glands.
6.
Reproduction. Gonadal structure and development. Viviparity in
fishes.
C.
Ecology and behavior. Including predator-prey relationships,
--
------__cornpet-i-t-ion,-i-n-tra-spec-if4c--interac-tions--ond--odaptht1on to vartous
environments. ?
-
D.
Migration with emphasis on patterns, orientation, bioenergetics
and physiology.
Laboratory
Anatomy.
Dissection of 3-4 differing species that are available at the time
and are of an adequate size (salmon, rockfish, dogfish, hagfish,
flounder, ling cod).
Identification and classification.
In addition to museum specimens, students will make their
UWfl
day and night collections by a variety of means (scuba, beach
seine, hook and line, trawl). In order to relate various species
with different habitats fish will be collected from estuaries,
rocky intertidal, exposed beaches, mud flats, sea grass flats, kelp
beds, near-shore rocky bottom, near-shore soft bottom, deeper
sublittoral and mesopelagic areas as well as stream and lake
habitats.
Field trips to natural spawning grounds (Carnation Creek, Sweltzer
Creek), artificial spawning grounds and rearing facilities
(Robertson Creek, Capileno Hatchery, Weaver Creek) and
equaculture operations (Pacific Biological Station, Tidal Rush
Marine Forms).
Lab experiments in physiology and behavior in areas of faculty
research - predator-prey interactions, cardiac physiology,
- -
?
endocrine regulation and fish toxicology.
Text
Fishes:An Introduction to IchthyQiQgy, P.B. - Moyle and J.J. Cech,L,
Prentice- Hall, ç, 1962.
?
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SENATE COMMITTEE ON UNDERGRADUATE STUDIES
NEW
COURSE PROPOSAL FORM
?
?
AMMENDED: FACULTY OF SCIENCE?
29/ Sept./86
1.
Calendar Information ?
Department: Biological Sciences
Abbreviation
Title of Course:Code:
?
BISC
Biotechnology
?
Course
-
Number:
Industrial
423
?
Applications
Credit Hours: 4 Vector:
--I
Calendar Description of Course:
The use and manipulations of microbial
?
:ultures for production and
extraction of
?
important compounds will be studied.
industrially
Nature of Course Lecture and Laboratory. Two - three hour laboratories per week
Prerequisites (or special instructions)
?
are required.
BISC 303, BISC 321 recommended.
What course (courses), if any, is being dropped from the calendar if this course is
approved:
BISC 421
2.
Scheduling
How frequently will the course be offered? Once/year
Semester in which the course will first be offered? UKA 87-3
Which of your present faculty would be available to make the proposed offering
possible?
?
L.J. Albright
3.
Objectives of the Course
Biotechnology is a rapidly expanding field in which industry is using bacteria,
fungi, viruses and plant and animal tissue cultures to obtain useful materials.
This course will show students how to select industrially important microbial,
plant and animal cells, maintain them, modify them to enhance their product
formation in bioreactors and to isolate the desired product.
4.
Budgetary and Space Requirements (for information only)
What additional resources will be required in the following areas:
Faculty ?
None
Staff ?
None
Library ?
Subscription to: Applied Microbiology and Biotechnology
Audio visual None
Space ?
None
Equipment ?
$1,000 for bioreactors, $3,000 for a tissue culture incubator with
ancillary glassware, $4,000 for niicrolitre pipettes, microfuge, etc.
5.
Approval
Date:
a
l
lo
41 October/1986.
Department
('^j
Chairman
?
Dean
?
Chairman, SE-IS
SCUS 73-34b:- (When comoletin
q
this form. for instructions see Memorandum SCUS 73-34a.
41 ?
•e
.
S
LECTURE SCHEDULE
Lecture
?
1
?
Introduction to Biotechnology
?
2
?
Culture collections
?
3 ?
Bioreactors: Design and Operation
?
4 ?
All Propagation: Viral, Bacterial, Fungal, Algal and Plant and
Animal Cell Growth Patterns
?
5 ?
Cell Propagation: Batch Cultures
?
6
?
Cell Propagation: Continuous Cultures
?
7 ?
Cell Propagation: Continuous Cultures
?
8 ?
Midterm Exam
?
9 ?
Anaerobic Pathways Useful for Product Formation
?
10 ?
Anaerobic Pathways Useful for Product Formation
?
11 ?
Bioreactor Products Related to the TCA Cycle
?
12 ?
Bioreactor Products Related to the TCA Cyle
?
13 ?
Idiolite Production
?
14 ?
Idiolite Production
?
15
?
Microbial Adherence
?
16
?
Production and Use of Immobilized Cells
?
17 ?
Production and Use of Immobilized Enzymes
?
18 ?
Midterm Exam
?
19
?
Automation and scale-up of Biological Process Engineering
?
20
?
Manipulation of yeast for Desired Product Formation
?
21 ?
Brewing and Spirits Production in Theory and Practise
?
22 ?
Microorganisms and the Oil Industry
?
23 ?
Genetic manipulation of viruses and bacteria for commercial
vaccine production
?
24 ?
Applications of microbial biotechnology in agriculture and
forestry
?
25 ?
Use of microorganisms in mineral extractions
BIOTECHNOLOGY - INDUSTRIAL
APPLICATIONS
WEEK
1
Selection and Preservation of Industrial Cell Strains.
Demonstration of bioreactor Types.
WEEK 2
Batch culture of Penicillium:
?
Kinetics of Cell Growth and
Penicillin Formation.
WEEK
3
Batch Culture of Penicillin:
?
Penicillin Purification and
Bioassay.
WEEK k
Continuous Yeast Culture: ?
Part I.
WEEK
5
Continuous Yeast Culture:
?
Part II.
WEEK
6
Mechanisms of Bacterial Adherence:
?
Reversible and
Irreversible Attachment*.
WEEK 7
Production and bioassay of a Bio-insecticide.
WEEK
8
Fusion as a Technique for Altering Industrially Important
Yeasts*.
-
? WEEK
9
Product Formation by a Hybridoma*.
WEEK 10
Klenow Fragment Preparation from Escherichia coli*.
WEEK
11
Scale-up Problems in Industrial Bioreactors*.
WEEK
12
Ethanol Production by Immobilized Yeast.
WEEK
13
Glucose Isomerase:
?
An Important Industial Immobilized Enzyme.
S
L]j
?
4 ?
,-
SENATE COMMITTEE ON UNDERGRADUATE STUDIES
NEW COURSE
PROPOSAL FORM
1.
Calendar Information ?
Department: Biology
Abbreviation Code: BISC
?
Course Number: 431
?
Credit Hours: 4
?
Vector: 3-0-6
Title of Course: Molecular Biotechnology
Calendar Description of Course:
Laboratory with accompanying lectures to give practical experience in the
application of recombinant DNA technology to basic and applied research.
Nature of Course
Prerequisites (or special instructions)
BISC 321, or permission of instructor. Recommend BISC 401 and/or BISC 402
concurrently.
?
- - - - - -- -
What course (courses), if any, is being dropped from the calendar if this course is
approved:
BISC 421
2. Scheduling
How frequently will the coarse be offered?
?
once/year
Semester in which the course will first be offered? XCC 87-1
?
. ?
Which of your present faculty would be available to make the proposed offering
possible?
Dr. B. Honda (Drs. Baillie, Smith also possible).
3.
Objectives of the Course Biotechnology and recombinant DNA methodology are
rapidly finding wide applications in various areas of biology (from taxonomy
to evolutionary studies), as well as in applied fields. The purpose of this
course, following the theoretical background of BISC 321, is to provide practical,
hands-on laboratory experience with technical aspects of recombinant DNA
technology. BISC 421 was split into two courses because: (1) the two areas
covered are so different in requirements and scope, and (ii) to allow material
in each area to be covered adequately in more depth.
4.
Budgetary and Space Requirements (for information only)
What additional resources will be required in the following areas:
Faculty
Staff
Library Ref. list attached with course outline.
Audio Visual
Space Lecture room (20-25), and lab space for two afternoons/week.
Equipment Most required equipment already available; some small items
(pipetmen, power supplies) and disposables necessary.
5.
Approval
Date:
?
4/October/1986
Department Chairman
?
Dean
?
Chairman, SCtj
SCUS 73-34b:-
(W
.......
cornoleting this form, for instructions see Memorandum SCUS 73-34a.
BISC 41,21 , X ?
MOLECULAR BIOTECHNOLOGY
Lectures and laboratories coveringthe following topics:
Introduction: Overview of molecular biology
bacteria:
?
growth and maintenance
vector-host system--
Manipulating DNA: ? restriction enzymes
other enzymes used in molecular cloning
gel electrophoresis
hybridization, blots
F'lasinid vectors: ?
properties, construction
isolation from bacteria
cloning protocols
Phaqe vectors:
?
properties, construction
growth and maintenance
cloning protocols, packaging
Cloning strategies: ?
making cDNA
probes, selection, characterization of
desired genes
DNA sequencing: ?
Maxain and Gilbert (chemical) sequencing
Sanger (enzymatic) methods
Expression of eukaryotic genes in bacteria: production of biologically
important substances
Eukaryotic vector systems:
?
yeast
mammalian cells
transgenic organisms
plant vectors and prospects
Tissue culture technology, monoclonal antibodies
REFERENCE LIST
)'niiatis, T. et al. Molecular Cloning (A Laboratory Manual), New York,
Cold Spring Harbor Laboratory (1982). ISBN 0-87969-136-0
Wa t
s
on,
J.D. et al. Recombinant DNA: A Short Course. W.H. Freeman, NY,
(1983). ?
ISBN 0-7167-1484-1
Recombinant DNA Methodology, Dillon, Nasirn and Nestmann eds, Wiley and
Sons, Toronto, (1985). ISBN 0-471-89851-1
Rodriguez and Tai t , Recombinant DNA Techniques, An Introduction, Addison
Wesley, Don Mills (1983),
Genetic Engineering, R. Williamson ed. , VOL
3 4
Academic Press (1982).
Also various scientific journals and reference texts presently held'in the
library.
S
