S.88-77
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SIMON FRASER UNIVERSITY
MEMORANDUM
TO: Senate
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FROM: ?
J.W.G. Ivany
Chair, SCAP
SUBJECT:
New Graduate Course
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DATE: ?
Nov.
15,
1988
- KIN 812-3
Action undertaken by the Senate Committee on Academic Planning/Senate
Graduate Studies Committee gives rise to the following motion:
Motion:
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that Senate approve and recommend approval to the
Board of Governors as set forth in S.88-77 the proposed
new graduate course
KIN 812-3 ?
Molecular and Cellular Cardiology
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sl:Y YRAR UiViSlTY
"ev Crouate Course Pro
p
osal rorm
cALF:mAR lFOR'ATION:
Department:Kinesiology ?
_Course Number:KIN 8
Title: ?
MoLec'iilar and Cellular Cardiology
Description: This course involves biochemical and biophysical analyses of cardiac
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function. Topics for dicussion include excitation, contraction., E-C coupling and
the regulation of pIlj.
Credit flours: ________
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Vector: ?
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Prerequisite(s) if any:_________
Introductory biochemistry and biophysics
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ECft.LMENT AND SCHEDULING:
Fstitcd Enrollment: 5-10
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_Then will the course first be offered:
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Fall '87
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flow often will the course be offered:Once ever
y two years
JUSTIFICATION:
There is no such course offered in this department or any other
department on campus. This course has been offered several times
as KIN 806 and has had wide student appeal.
RESOURCES:
'hich Faculty ne'ber will normally teach the course:
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(-'i
Tihbjt-
what are the budgetary im
p
lications of mounting the course: none
Are there sufficient Library resources (anoend details):
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Yes
Appended: a) Outline of the Course
b)
An indication of the competence of the Faculty member to give the course.
c)
Library resources
Approved: Departmental Graduate Studies Co:.mittee:
///7j
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•Z._—_Date:
12-
Faculty Graduate St dies Committee:
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,,t-f L.— Date: I
ITY
Faculty.
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-
Date:
Senate Graduate Studies Comrnittee:
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_Date:
Senate: ?
______ Date:
MOLECULAR & CELLULAR CARDIOLOGY?
COURSE OUTLINE
1.
Morphology and Ultrastructure
analysis of myocyte ultrastructure from electron micrographs
2.
Contraction
contractile protein biochemistry, Ca
2+
requirements for contraction
3.
Electrophysiology and Membrane Transport
biophysics and molecular biology of Na, K, Ca channels and the
Na/Ca antiporter
4.
Excitation-Contraction Coupling
calcium-induced calcium release and 1P
3 models of SR Ca
2+
release
5.
Regulation of Contractility
B
agonist, cAMP and calmodulin regulation of intracellular calcium
6.
Heart as a Pump
muscle biomechanics, Starling, pressure-volume and force-velocity
relationships in the myocardium
7.
Myocardial Metabolism
glycolysis, B-oxidation
8.
Coronary Blood Flow
vascular smooth muscle biology, autoregulation of CBF
8. ?
Atherosclerosis
etiology of plaque development in coronary arteries, molecular
biology of lipoproteins and mitosis of vascular smooth muscle
9.
Ischemia
regulation of pH
i , Na/H antiporter, free radicals and other
mechanisms of ischemia-induced cell damage
10.
Adaptation to Stressors
intrinsic myocardial adaptation to both pressure and volume overload
conditions; myosin isozyme shifts, alterations in E-C coupling and
hypertrophy
S
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