S.95-18

48

?

SIMON FRASER UNIVERSITY

OFFICE OF THE VICE-PRESIDENT, ACADEMIC

?

MEMORANDUM

To: ?

Senate

From: ?

J. M. Munro, Chair

Senate Committee on Academic Planning

Subject: ?

Proposed MBB Graduate Program

Date: ?

February 13, 1995

Action undertaken by the Senate Graduate Studies Committee and the Senate Committee

on Academic Planning gives rise to the following motion:

• ?

"That Senate approve and recommend approval to the Board of Governors

as set forth in S.95 - 18, the proposed graduate program in Molecular

Biology and Biochemistry including:

New courses:

MBB 801 - 2 ?

Student Seminar in Molecular Biology and Biochemistry I

MBB 802 - 2

Seminar in Molecular Biology and Biochemistry II

MBB 806 - 3

Ph.D. Graduate Research Seminar

MBB 811 - 1

Techniques in Molecular Biology and Biochemistry

MBB 812 - 2

Techniques in Molecular Biology and Biochemistry

MBB 813 - 3

Techniques in Molecular Biology and Biochemistry

MBB 821 - 3

Nucleic Acids

MBB 822 -3

Biological Membranes

MBB 823 - 3

Protein Structure and Function

MBB 824 - 3

Physical Biochemistry

MBB 825 - 3

Bioenergetics

MBB 826 - 3

Molecular Immunology

MBB 827 - 3

Mechanisms in Enzyme Catalysis

MBB 828 - 3

Spectroscopic Methods in Biochemistry

MBB 829 - 3

Special Topics in Biochemistry

MBB 831 - 3

Molecular Evolution of Eukaryote Genomes

2

---

MBB 832 - 3

Molecular Phylogeny and Evolution

MBB 833 - 3

Developmental Genetics

MBB 834 - 4

Topics in Developmental Biology

MBB 835 - 3

Genome Analysis

MBB 836 - 3

Gene Expression

MBB 837 - 3

Molecular Genetics of Signal Transduction

MBB 839 - 3

Special Topics in Molecular Biology

MBB 871 - 1

Directed Readings in Molecular Biology and Biochemistry

MBB 872 - 2

Directed Readings in Molecular Biology and Biochemistry

MBB 873 - 3

Directed Readings in Molecular Biology and Biochemistry

Deletion of:

CHEM 823 - 3

Selected Topics of Special Biochemical Interest

CHEM 825 - 3

Bioenergetics

BISC ?

881 - 3

Special Topics in Cell and Molecular Biology.'

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Agreement has been reached between the Faculty of Science and the Library

in the assessment of library costs associated with the new courses

0

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.

SIMON FRASER UNIVERSITY

OFFICE OF THE DEAN OF (;RADI ATE STUDIES

Memorandum

TO: Senate Graduate Studies Committee

?

FROM: Bruce P. Clayman

Dean of Graduate Studies

SUBJECT: MBB

Graduate Program

?

DATE: December 23, 1994

This is to provide clarification of the nature and status of the Molecular Biology and Biochemistry

(MBB) Graduate Program proposed by the Faculty of Science. As you will note from page 2 of

the letter from Dean Cohn Jones dated June 23, 1994, this program is

not

really a new degree

program.

It is essentially a set of MBB graduate courses and MBB degree requirements, expressed in terms

of those courses; there is an MBB steering committee that guides the program and makes recom-

mendations to the departmental Graduate Program Committees in Biological Sciences and Chem-

istry. All students are enrolled in one of those two departments and receive their M.Sc.

or Ph.D.

degrees from Senate upon recommendation from that department. Graduate degree parchments

do not specil\' the area of concentration and thus will simply confer an M.Sc. or Ph.D. The MIBB

courses are creatures of both departments and therefore new and revised courses require the ap-

proval of both departments as well as that of the Faculty of Science.

I note that implicit in this proposal is the deletion of

CI-IEM

823 and 825 and BISC 881. Any

motion for approval should include this explicitly.

I view this as an interestin

g

and positive example of inter-departmental cooperation and collabo-

ration in an area of common interest. I recommend approval b

y

the SGSC in the hope that imple-

mentation in fall

95-3

will be possible.

in

..

?

P.r\l. \Vrcun

B. Brandhorst

C.H.W. Jones

S

MDE23SOSDOC 23-l94

---

ACNGP 94-1

PROPOSAL FOR M,SC. & PHD IN

?

MOLECULAR BIOLOGY & BIOCHEMISTRY

?

Nov 1992 ?

Approved "in-Principal" by Senate Committee

on Academic Planning

?

23 Jun 1994

?

Approved by Faculty of Science Graduate

?

Studies Committee

?

11 Jul 1994

?

Received by the Dean of Graduate Studies

?

06 Dec 1994

?

Reviewed by Assessment Committee for New

?

Graduate Programs

?

09 Jan

1995 ?

Reviewed by Senate Graduate Studies

Committee

COV-MBB.DOC 12/20/94

---

SIMON FRASER UNIVERSITY

DEAN OF GRADUATE STUDIES

?

Memorandum

TO: ?

B.

P. Clayman

?

FROM:

Phyllis M. Wrenn

Chair ?

Associate Dean

Senate Graduate Studies Committee ?

Chair, ACNGP

SUBJECT: MSc

& PhD in Molecular Biology ?

DATE:

December 20, 1994

&

Biochemistry

The Assessment Committee for New Graduate Programs (ACNGP) has approved and

recommends to the SGSC for approval a proposal for an MSc

and a PhD in Molecular Biology

& Biochemistry. The first draft of the proposal was received on 23 June 1994. The ACNGP

decided to recommend approval of the programs without requiring an external review. The

ACNGP noted that these programs, offered jointly by the Departments of Chemistry and of

Biological Sciences, will be included in the next External Review of the Department of Biological

.

?

Sciences.

Please place this proposal on the agenda of the January 9, 1995 meeting of the SGSC. By copy of

this memo, I am inviting B. Brandhorst to attend this meeting as a representative of the proposed

programs.

rN

it

End.

C: ?

B. Brandhorst?

C. Jones

M. McGinn

CMT\AC'N(;I'h1-SC,SC5.I)0C 12/20/94

?

L^-

---

SIMON FRASER UNIVERSITY

DEAN OF GRADUATE STUDIES

Memorandum

?

.

TO: ?

B.

Brandhorst ?

FROM: Phyllis M. Wrenn, Associate

I1M1BB ?

Dean of Graduate Studies,

•Chair, ACNGP

SUBJECT: MSc and PhD in Molecular Biology

?

DATE: December 16, 1994

& Biochemistry

I am pleased to confirm that the Assessment Committee for New Graduate Programs (ACNGP)

voted to recommend that the proposal for an MSc and PhD in Molecular Biology and

Biochemistry be forwarded to the Senate Graduate Studies Committee, subject to the following

changes, to be completed to the satisfaction of the Chair of the ACNGP (myself).

1.

The proposal should be revised to eliminate apparent duplication (clearly differentiating

calendar entry

from descriptive proposal), and to clarify the history of previous offerings (as

Special Topics) of courses included in the proposal, in order to make clear what is new and what

is not.

2.

A timing matrix - projection of course offerings / staffing (4 - 6 years) should be included, and

related to previous offerings.

?

0

3.

Course outlines should be revised as required to include a specific statement of faculty

competence (example BISC83I, etc.).

4.

A covering statement pointing Out the relevance of the format of the Library review to the

bibliographic format/aims of the proposed courses would be useful.

I look forward to receiving your revised proposal as soon as the changes requested are complete,

and will forward it for inclusion on the agenda of the next meeting of SGSC, as soon as possible.

S

M-SGSC5ADOC 12/16/94

---

. ?

SIMON FRASER UNIVERSITY .

JU

1'94

MEMORANDUM

To: ?

B.P. Clayman, Dean

?

From: C.H.W. Jones, Dean

Graduate Studies

?

Faculty of Science

Subject:

MBB Graduate Programme

?

Date: June 23, 1994

I am pleased to forward to you a proposal for the establishment of a graduate

programme in Molecular Biology and Biochemistry which will be offered by both the

Departments of Biological Sciences and of Chemistry as a stream within the graduate

programmes of those two Departments.

The Context

The Institute of Molecular Biology and Biochemistry was established in the

summer of 1987 to "...enhance and promote basic research in molecular biology and

biochemistry and to coordinate graduate education in those disciplines." The Funds

for Excellence in Education Programme provided funding which allowed the

establishment of six new faculty positions in this area (Drs. Brandhorst, Price, Boone,

Borgford, Sen and Scott), and these appointments were made within the Departments

• of Biological Sciences and Chemistry. These positions were in addition to those

faculty in Biological Sciences and Chemistry already in the areas of Molecular Biology

and Biochemistry (Drs. Honda, Smith, Baillie, Beckenbach, Cushley, Richards and

Cornell). On the basis of this developing new initiative, the University was successful

in securing funding for a new building (the South Science Building) which would

accommodate the graduate teaching and research programmes of the Institute, as well

as providing additional research and undergraduate teaching space for the

Departments of Biological Sciences and Chemistry. Construction of this building was

completed in May 1993 and the building was formally opened in November 1993.

With the arrival of the new faculty in the Institute, the need for a clearly defined

graduate programme in molecular biology and biochemistry quickly became apparent.

In June 1992 the IMBB brought forward a Statement of Intent for the establishment of a

new, independent graduate programme and this was forwarded to the Departments of

Biological Sciences and Chemistry for their input. In October 1992 the Faculty of

Science voted to approve the Statement of Intent, and it was then forwarded to the

Senate Committee on Academic Planning, which approved it in November 1992. The

detailed planning of the new graduate programme proposal then began.

The Graduate Pr

pQr

p

mme in Molecular Biolo

gy

and Biochemi

While the original intent was for the programme to be quite independent,

discussions with Biological Sciences and with Chemistry during Fall 93 and Spring 94

led to the conclusion that a graduate Molecular Biology and Biochemistry programme

---

0

CHWJ:ln

c:

?

B.P. Brandhorst

B.A. McKeown

A.C. Oehlschlager

S. Thomason

3

)V)

C.H.W. Jones

that V'öUld be offered both Within Biological Sciencesand within Chemistry would best

suit the needs of the students in the 'programme and of the parent Departments.

The key features of the proposal are:

1.

A new programme of MBB courses is established which will service MBB

graduate students in both Biological Sciences and Chemistry and will be

offered by these two departments under the aeis of their degree programmes;

2.

The requirements for the M.Sc. and Ph.D. degree programmes are specified in

terms of these MBB courses;

3.

Graduate applications in the area of Molecular Biology and Biochemistry will be

screened for admission by the MBB Steering Committee and will be

recommended to the appropriate Departmental Graduate Studies Committee

for admission into that Department;

4.

Graduate supervisory committees and thesis examining committees will be

ratified by the Department GSC's on the recommendation of the MBB Graduate

'Programme Committee;

5.

The MBB GPC will make recommendations on students eligible for Fellowships

and Scholarships to the appropriate Department GSC for consideration along

with other graduate students in that Department;

6.

The MBB graduate students will enjoy all the benefits and privileges of being a

student of their home Department;

This proposal has been approved independently by the Departments of

Biological Sciences and Chemistry and by the Faculty of Science as a whole

(May 26, 1994).

Recommendation

That the proposal for a new graduate programme in Molecular Biology and

Biochemistry within the Departments of Biological Sciences and Chemistry be

presented to the Senate Graduate Studies Committee for their consideration and

approval.

---

• ?

To:

Dean,

Dr.

Faculty

Cohn Jones

of Science

??

From:

Director,

Dr.

IMBB

Bruce Brandhorst ,

fr

of

Budgetary

the Graduate

implications

Program

of

in

implementation

Molecular

?

June 8, 1994

Biology and Biochemistry

I have outlined below the budgetary implications that I foresee of

creating a Graduate Program in Molecular Biology and Biochemisty as

streams of graduate programs in the Departments of Chemistry and

Biological Sciences:

1.

Faculty staffing. The Institute of Molecular Biology and Biochemistry

(IMBB) was founded in 1987 to promote graduate training and research.

The establishment of a graduate program in molecular biology and

biochemistry was anticipated at the time. Since then an allocation of Funds

for Excellence in Education (FEE) has resulted in the hiring of 6 new faculty

members as well as administrative and secretarial support staff. The 13

faculty members of IMBB will be able to mount the proposed graduate

program of 10-12 courses per year while continuing their balanced and

reasonable commitment to undergraduate teaching programs in Biochemistry

and Biosciences. However, it will be essential that teaching replacement

funds be provided for faculty who are unavailable to teach e.g. because of

sabbaticals or leaves. A replacement for the vacant position in Biochemistry

eliminated in recent (92-93) budget cuts will be sought.

2.

Library collection: The proposals for new courses for the program

included a list of books and journals which are desirable, though not

essential, for the proposed program. These include some books and serials

already identified as essential for courses in the undergraduate programs,

but not yet acquired by the library. Most of the serials listed have high

impact ratings and have been requested by several faculty members (mostly

new recruits); they would be important additions to the research collection

of the library. Ralph Stanton at the Library has estimated that the one time

cost for books is $388 and the recurring cost to acquire all serials is $3,517

per year. I would prefer to see these serials acquired through adoption of

an appropriate user-based assessment mechanism designed to allow the

collection to evolve to meet the changing needs of its users. However,

have

uncommitted

proposed.

FEE funds could be used for the library acquisitions, as you

3.

Office staff: There will be a requirement for some secretarial help with

the processing of inquiries and applications to the program, which the IMBB

will be handling. We also anticipate tracking the progress of our students

(currently 42) through the program. There will be no immediate increase in

the number of graduate students in Departmental programs and only modest

increases are anticipated over the next few years. It may thus be possible

for the Departments of Chemistry and/or Biological Sciences to provide this

secretarial support.. Alternatively, uncommitted FEE funds could be used to

create a part-time position of graduate secretary, as you have proposed.

C

0

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..................

i'..

?

rr

1'

1;

i:.:4'.• ?

J.

From: Bruce Brandhorst

Director, Institute of Molecular Biology and Biochemistry

Re: Proposal for the Graduate Program in Molecular Biology

and Biochemistry.

A revised set of documentation is attached. It

includes:

1.

"Proposal for a Graduate Program in MBB" written in the

format of the University President's Committee form for new

programs. It includes a description of the proposed

program, complete with history, justification, documentation

of the need for the program and projected enrollments,

organization of the program, and financial considerations.

verbatim

The proposed

from

"Organization

the original

of

"Proposal"

the program"

document

is derived

approved by

the Faculty of Science; this document has now been deleted

to avoid confusion with the "Calendar Entry" document.

2.

Appendix 1. The proposed "Calendar Entry", describing

the admission and degree requirements, as well as the

courses to be offered. The course descriptions have been

shortened in several instances.

3.

Appendix 2. This is a summary of the relationship of

proposed courses to existing CHEM and BISC courses. In

addition, a tentative 4 year cycle of MBB graduate course

offerings is included (starting in 95-3).

4.

Appendix 3. A discussion of the budgetary implications

with respect to library acquisitions, which have become

negligible. It refers to Ralph Stanton's report, but I have

not included his report. We currently regard the library

resources to be adequate to mount the proposed courses,

which should not be surprising since most courses have

previously been offered in the past three years.

5.

Descriptions of each of the proposed MBB courses. In

many instances these have been revised to provide ample

indication of the competence of the instructor (where

applicable) and a consideration of the library resources,

which we currently regard as adequate. The "justification"

sections have been expanded in some instances.

I have not included other documentation from the Dean

of Science, Cohn Jones.

I hope these modified documents will facilitate the

next steps in the consideration of this program. Please

contact me at any time if more information is required.

To: Dr. Phyllis Wrenn

Associate Dean, Graduate Studies

---

.

?

Proposal for a Graduate Program in Molecular Biology and Biochemistry at

Simon Fraser University

I.

General Information:

Title: Graduate Program in Molecular Biology and Biochemistry.

Credentials to be awarded to Graduates: M.Sc. and Ph.D.

This interdepartmental program will be administered by a Steering

Committee consisting of Members of the Institute of Molecular Biology and

Biochemistry (IMBB), who are drawn from the Departments of Biological

Sciences and Chemistry of the Faculty of Science. In addition, Associate

Members drawn from these Departments as well as from other Departments

and Faculties (e.g., Kinesiology, Applied Sciences) may participate in the

program. The MBB Graduate Program will operate as two parallel streams in

the graduate programs of the Departments of Chemistry and Biological

Sciences.

Date of Senate Approval: ?

A Statement of Intent (submitted in June, 1992) has been approved by the

Faculty of Science (Oct. 5, 1992) and SCAP (Nov. 4, 1992). The proposed

program has been approved by the Departments of Chemistry and Biological

Sciences, and by the Faculty of Science (May 26, 1994).

Projected starting date: September, 1995.

II.

Program Description and Related Matters.

Objectives of the Program

The objective of the proposed program is to provide advanced

education at the graduate level in research methods and state of knowledge

of molecular biology and biochemistry. The program will emphasize training

in basic research, but the knowledge and experience gained will be useful

for more applied research problems.

Relationship to the Role and Mission of SFU

The role and mission of the University is to educate students and

discover important new knowledge concerning the natural world and the

human experience. Graduate education in the sciences is a research

apprenticeship which should focus on the frontier areas in which important

new knowledge is rapidly generated. Molecular biology is the vanguard of

the revolution in the biological sciences and has been at the forefront of

biomedical research for over two decades. Biochemists now rely on the

methods of molecular. biology

(viz

cloning, sequencing, and manipulation of

genes and their protein products) as an essential component of their

. ?

research on the structure, function, and regulation of activities of

macromolecules. The methods of molecular biology are now being applied

to all the traditional disciplines of the life sciences, offering opportunities for

important new advances. The IMBB includes members having a range of

---

-2-

interests in biochemistry and biology who all rely on applications of the

methods of molecular biology.

History and DurDose of the JMBB

The interdepartmental Institute of Molecular Biology and Biochemistry

(IMBB) was founded by SFU in 1987 to promote basic research in these

disciplines and to coordinate graduate education. The establishment of the

MBB Graduate Program is a fulfillment of the graduate education component

of that mandate. Members of the IMBB currently train graduate students

through graduate programs in their respective departments of Chemistry and

Biological Sciences. These departments have substantially different degree

requirements and focus on traditional disciplines. Formal graduate course

offerings in molecular biology and biochemistry have been irregular,

infrequent, and unintegrated. The establishment of the MBB Graduate

Program will allow the implementation of a rational and integrated training

program more appropriately designed for its students. The Director of the

IMBB, as Chair of the Graduate Program Committee, will be responsible for

the planning and implementation courses in the MBB Graduate Program.

Scheduling of MBB courses will be through regular consultation involving

the Director of IMBB, the Chair of the interdepartmental Biochemistry

Curriculum Committee, and representatives Of the Departments of Biological

Sciences and Chemistry. The Dean of Science will supervise this

consultative process.

The IMBB initially included 6 founding members, too few to offer a

coherent graduate program. Six new members, including a Director, were

externally recruited using an allocation of Funds for Excellence in Education.

Two members were recruited internally and one resigned. Currently there

are 13 members. In addition, there are 10 Associate and 2 Affiliate

members holding appointments in the Departments of Biological Sciences,

Chemistry, and Kinesiology. Students of Associate members may be

accepted into the program.

RelationshiD to other

g

raduate programs in British Columbia

Somewhat similar programs in B.C. are offered by the Department of

Biochemistry and Microbiology at U. Victoria and the Department of

Microbiology at UBC. These Departments are oriented toward applications

of molecular biology and biochemistry to microbes and viruses, as well as

some problems of immunology. The recently renamed UBC Department of

Biochemistry and Molecular Biology is mainly focused on traditional

problems of human medical biochemistry, though the techniques of

molecular biology are frequently used. The proposed MBB program is

unique in that it focuses on the application of molecular biological and

biochemical methods to a range of basic research problems concerning a

broad variety of eukaryotic organisms. The interdepartmental Genetics

Graduate Program at UBC is similar in design to the proposed MBB Graduate

Program, but concentrates on traditional genetics.

The

IMBB

has focused its research efforts on developmental and

molecular genetics, molecular evolution and phylogeny, cellular signalling,

and macromolecular structure, recognition, and function. The research

tends to take an interdisciplinary approach and the MBB Graduate Program

---

-3-

will emphasize this. In terms of research interests and focus, the MBB

Graduate Program is distinct from other programs of B.C. Universities.

Or g anization of the program

(As approved by the Faculty of Science, May 26, 1994)

The interdepartmental MBB Graduate Program is administered by a

Steering Committee consisting of members of the Institute of Molecular

Biology and Biochemistry (IMBB), and chaired by the Director, IMBB.

Members of the IMBB have appointments in the Departments of Biological

Sciences or Chemistry. In addition, the IMMB has Associate Members from

these and other departments who may participate in offering the graduate

program, including serving as Senior Supervisors (or Co-Supervisor in the

case of Associate Members not in the Departments of Biological Sciences or

Chemistry).

A student in the MBB program is defined as a student whose Senior

Supervisor is a Member or Associate Member of the IMBB and who has

been admitted to the MBB Graduate Program.

The MBB Graduate Program Committee (GPC) is elected by the MBB

Steering Committee and coordinates operation of the MBB Graduate

Program. It reviews and selects applicants recommended for admission,

ranks MBB students for scholarships and fellowships, recommends the

• appointment of Supervisory Committees, monitors progress of students in

the program, and recommends Thesis Defense Committees in accordance

with SFU General Graduate Regulations.

The Graduate Supervisory Committee of each student will consist of

the Senior Supervisor and at least two other members recommended to the

GPC by the Senior Supervisor in consultation with the Student. At least one

member of the Supervisory Committee must be a member of the MBB

Steering Committee.

Students recommended for admission to the MBB Graduate Program

must also be admitted to the Graduate Program of the department of the

Senior Supervisor. The Departmental Graduate Studies Committee of that

Department will review and ratify the recommended Graduate Supervisory

and Thesis Defense Committees of each MBB student. The ranked list of

MBB students applying for SFU Graduate Fellowships and other scholarships

will be submitted to the appropriate Departmental Committee for

consideration with other departmental candidates. A member of the

Chemistry Graduate Studies Committee will be selected by mutual consent

of the MBB Steering Committee and the Department of Chemistry.

Curriculum and degree re

q

uirements of the program

(Approved by the Faculty of Science, May 26, 1994)

•

?

?

Students in the MBB Graduate Program will meet its admission and

degree requirements. The curriculum and requirements of the MBB graduate

program, including a list of faculty and their research interests, is attached

as a proposed Calendar entry as Appendix 1.

1/.

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-4-

Several of the proposed graduate course offerings already exist as

courses in Chemistry and Biological Sciences. These would be replaced

with MBB courses, but would continue to serve interested graduate students

in those Departments. Most of the other proposed courses have been

offered in recent years as Special Topics courses in Chemistry or Biological

Sciences and will now be formalized. Some are new courses, to be offered

by newly recruited faculty or in response to need and opportunity. A

tentative 4 year schedule of MBB courses and an outline of the relationship

of new courses to existing courses is included as Appendix 2.

Ill. ?

Need for the program.

Im p

ortance of the Disciplines

Many of the important recent advances in biomedical research and

their application to clinical practice have been based on the results of basic

research in molecular biology and biochemistry, and the closely related

disciplines of genetics, cell biology, developmental biology, and

microbiology. Further improvements in health care will undoubtedly

continue to benefit from the efforts of researchers trained in molecular

biology and biochemistry. Such scientists also form the research core of

the burgeoning biotechnology industry, which should continue to offer great

opportunities for generating employment as new knowledge is applied to

important problems. Molecular biologist have been the driving force behind

the widely acknowledged revolution in the life sciences, and will continue to

be at the forefront of scientific research for many years to come.

Demand for the program

A

pp

licants: A large fraction of inquirers and applicants to the graduate

programs of the Departments (40-50% in Biosciences; 20-30% in

Chemistry) express an interest in molecular biology or biochemistry. Based

on the numbers of qualified applicants interested in molecular biology and

biochemistry applying to these Departments, there is sufficient student

demand to mount this independent graduate program.

Current enrollment: Currently there are 22 M.Sc. and 22 Ph.D. students

supervised by members of the IMBB. Since 1987 members of the IMBB

have graduated 19 M.Sc and 18 Ph.D. students. Since the students in the

MBB Graduate Program would otherwise enter programs in existing

Departments, there will be no immediate impact on current graduate

enrollments. Laboratory space is no longer a serious constraint on student

numbers since the occupancy of the new South Sciences Building.

Projected demand: The highly visible and exciting successes of molecular

biology and biochemistry, and the breadth of employment opportunities, are

attractive to many prospective graduate students, including those with

strong qualifications. Thus we anticipate that demand for entry into the

program will continue to outstrip positions, enabling the selection of

excellent students.

Projected enrollment: The number of students in the MBB Program should

increase as recently recruited Assistant Professors expand their programs.

?

0

/.

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- 5 -

•

?

It is anticipated that most faculty participants in the Program will each

supervise 3-6 graduate students. The number of students in the program

will be limited by resources available to support graduate students and their

research and by the number of faculty members associated with the

program. Because of the key role of molecular biology and biochemistry at

the forefront of research in most disciplines of the life sciences it is

anticipated that the number of faculty and graduate students involved in the

MBB Graduate Program will increase substantially over the next several

years as retiring faculty in traditional biology disciplines are replaced by new

faculty using the methods of molecular biology. The number of students

admitted to the program may also be influenced by changes in employment

opportunities for students in the program. The program can operate

effectively with the 8-12 students admitted each year recently, but it is

anticipated that more will be accepted in future.

Opportunities for em

p lo y

ment of graduates.

Graduates of the M.Sc. program will find job opportunities in technical

positions in research laboratories of universities, government agencies, and

industries. Graduates of the Ph.D. program are likely to seek further post-

doctoral training before taking academic positions or making careers in

government laboratories or industry, especially the expanding biotechnology

and pharmaceutical industries.

We are not aware of detailed estimates of the current numbers of

• ?

candidates or employer demand for candidates trained in molecular biology

and biochemistry. A 1992 Ernst and Young report on Canadian

Biotechnology projected rapid growth of an industry that already employs

7,175 scientists in Canada. This industry depends on Universities to train

its prospective employees, most of whom will be molecular biologists. The

biotechnology industry in the USA is growing by 15% per year and provides

additional employment opportunities for Canadian graduates.

Although molecular biology has existed as a discipline for only about

30 years, its practitioners now dominate biomedical research in numbers

and scientific productivity. Of 31 "Hottest Research Fields" recently

identified by citation analysis by the Institute for Scientific Information from

all scientific disciplines, 25 were classified as molecular biology. This trend

is likely to. continue as molecular biological techniques are applied to other

disciplines; such novel applications are an important feature of the IMBB

research and graduate training programs. A large fraction of the

advertisements for Ph.D. scientists placed in the interdisciplinary

international journals

Science

and

Nature

require training in molecular

biology.

A recent report (released November, 1994) by the Royal Society of

Canada entitled "Molecular Biology and Canada's Future" points out the

critical importance of the discipline in medical research and projects a great

demand for young scientists trained in molecular biology in various key

industries, especially pharmaceuticals and biotechnology, as well as

agriculture, forestry, and aquaculture, in which Canada and B.C. have

particular interest.

/.

---

All of the graduates supervised by members of the IMBB have either

found full time employment or continued their education at leading

institutions. A recent survey of 785 Ph.D. graduates from Canadian

Universities in the life sciences between 1983-1992 indicates that about

95% are employed in science (NSERC Life Sciences Allocation Reports),

IV. ?

Present and Projected Resources and Requirements

Administrative re

q

uirements and resources

The IMBB already has a Director, who will Chair the MBB Steering'

Committee. The IMBB already has an Office and an Administrative

Assistant, who will be responsible for administering financial aspects of the

program and insuring that proper records are kept. IMBB graduate students

already receive their mail from the IMBB office, which oversees the budgets

of all IMBB research grants and appointments of IMBB staff and students.

Since initially there will be no net increase in the number of students in

either host department, clerical services for the program can be provided by

the Departmental Graduate Secretaries. As the program expands it may

become more effective to consolidate these clerical services in the IMBB;

uncommitted FEE funds remain available for this purpose.

Facult y

re q

uirements and resources

The faculty required to mount the MBB Graduate Program are already

in place in their respective Departments. A replacement for a departed

IMBB member would be useful for the program, though not essential for its

initiation. No TA positions will be required to offer the program. MBB

graduate students will have first priority access to Teaching Assistantships

in their respective Department in which their senior supervisor holds an

appointment and has teaching duties.

Librar

y

resources

The current SFU Library serials collection is adequate. Recent

additions made possible by cancellations have improved the quality of the

serials collection. In particular, additions to the serials collection originally

requested in proposals for MBB courses, and analyzed by Ralph Stanton of

the Library, have been ordered. The interlibrary loan system, proximity of

the superior UBC Library collection, and other methods for rapidly acquiring

copies of publications, make the limitations of the SFU collection tolerable.

The IMBB faculty place personal subscriptions of key journals, including

several not carried by the library, in a reading room. Most of the courses

are based in large measure on recent literature in serials and make little use

of texts and monographs, except for background reading, since such books

tend to be out of date upon publication. The utility of electronic media is

rapidly improving and will reduce the dependence on traditional library

collections.

Facilities available and ca

p ital requirements

The IMBB occupies the recently completed South Sciences Building

which provides well designed space for MBB graduate research training.

Capital allocations and equipment grants have already provided a good

19.

---

MAE

S

.collection of modern equipment housed in shared rooms. Besides research

laboratories which include desk and bench space for graduate students, the

building provides rooms for seminars, meetings, tissue culture, microscopy,

photography, video documentation, glassware washing, media preparation,

centrifuges, ultrafreezers, fermentors

'

radioisotope use, sea water tanks,

biohazard containment, maintenance of constant temperature, distribution of

mail, photocopying, and computers (including- an IMBB local network Unix

server, printers, and a variety of software and databases). The new 600

mHz NMR Spectrometer occupies IMBB space and is available for graduate

research. New capital allocations are not required to mount the MBB

Graduate Program, which will be administered through the IMBB Office,

which is already outfitted with furniture and office equipment. The

laboratory courses which may be offered will rely on shared and loaned

research equipment and facilities of the teaching labs.

Financial Resources for Graduate Training and Research

External funds for IMBB research and graduate training are currently

derived from several government agencies as well as some contracts with

private companies. In general, graduate students are not engaged in

contract research, though they benefit from the associated infrastructure

and presence of several highly skilled technicians. It is not anticipated that

external funds will be required or sought for the graduate program per Se.

The IMBB has received donations and gifts in the past which have helped

fund the completion and outfitting of the South Sciences Building and an

S ?

endowment for the MacMillan Bloedel-IMBB and Hemingway Nelson

Architects graduate scholarships for some IMBB graduate students; The

IMBB would welcome more such gifts, but its operations are not dependent

on them.

The faculty members participating in this program all hold NSERC

and/or MRC research grants. The 13 members of the IMBB hold research

grants totalling $1,230,047 for the current fiscal year (1994-95); total grant

(research and equipment) and contract income was $1,862,899. The value

of grants and contracts should increase as newly arrived members expand

their programs. Funding is received from the NSERC, MRC, BCHRF, CGAT

Genome Project, NIH (USA), Muscular Dystrophy Association, the U.S.

Army, and the B.C. and Yukon Heart Foundation, as well as from private

companies. The average NSERC Research Grant held by members of the

IMBB is $46,149, which for a department would be one of the highest in

Canada. The current and anticipated research funding for members of the

IMBB is sufficient to mount an active program of graduate research training.

.

-

---

B.P. Brandhorst

D.L. Baillie

A.T. Beckenbach

C.M. Boone

T.J. Borgford

R.B. Cornell

R.J. Cushley

B.M. Honda

J.V. Price

W.R. Richards

J.K. Scott

D. Sen

M.J., Smith

S

Appendix I (Calendar Entry)

?

The Graduate Program in Molecular Biology and Biochemistry

(MBB)

Location: 8166 South Science Building

Telephone: 291-5630

Director: Bruce P. Brandhorst AB (Harvard), PhD (California)

The interdepartmental MBB Graduate Program is administered by a

Steering Committee consisting of members of the Institute of Molecular

Biology and Biochemistry (IMBB). Members of the IMBB have appointments

in the Departments of Biological Sciences and Chemistry. In addition, the

MBB has Associate Members from these and other departments who may

serve as Senior Supervisors.

Faculty and Areas of Research

Biological Sciences (developmental biology and gene

regulation)

Biological Sciences (developmental genetics)

Biological Sciences (population genetics, molecular

evolution)

Biological Sciences (molecular genetics; cellular

signalling)

Chemistry (protein structure and function)

Chemistry (membrane bound enzymes)

Chemistry (high field NMR)

Biological Sciences (molecular biology and gene

regulation)

Biological Sciences (developmental genetics; cellular

signalling)

Chemistry (protein biochemistry; photosynthesis)

Chemistry (immunochemistry; immunology)

Chemistry (nucleic acid biochemistry; chromosome

structure)

Biological Sciences (molecular phylogeny and

development)

Associate Members and Department

A.J. Bennet

A.H. Burr

B.J. Crespi

L.D. Druehl

N.H. Haunerland

E. Käfer

A. Kermode

M.M. Moore

B.M. Pinto

A. Plant

G.F. Tibbits

Chemistry

Biological Sciences

Biological Sciences

Biological Sciences

Biological Sciences

Biological Sciences

Biological Sciences

Biological Sciences

Chemistry

Biological Sciences

Kinesiology

IL

---

-2-

Information

Information about the MBB Graduate Program and the research

activities of its faculty can be obtained from: The MBB Graduate Secretary,

IMBB, Simon Fraser University.

Admission

For admission requirements, refer to the

SFU Graduate General

Regulations.

Applicants should normally have completed some advanced

course work in biology or biochemistry.

Degree requirements

All students will be assigned a Graduate Supervisory Committee

which has the authority to specify an appropriate program of course work

meeting or exceeding the minimum requirements stated below.

All students are expected to attend the IMBB Research Seminar Series

and to participate regularly in a journal club.

M.Sc. Program

Course Work

?

9

The minimum requirements consist of 12 semester hours of graduate

course credits including MBB 801-2 and 802-2.

Research

A major part of the M.Sc. program will be devoted to original

?

research. A thesis describing the work must be submitted and defended in

accordance with

SFU Graduate General Regulations.

Ph.D. Program

Course work

For students entering with a B.Sc. or equivalent: a minimum of 20

semester hours of course credits of which at least 15 must be at the

graduate level, including MBB 801-2, MBB 802-2, and MBB 806-3. Ph.D

students must normally enroll in MBB 806-3 at the earliest opportunity

following 4 semesters of registration in the program. With the approval of

their Supervisory Committee, students in the M.Sc. program may apply to

the MBB Graduate Program Committee for transfer to the Ph.D. program.

For students entering with the M.Sc. degree: 8 semester hours of

course credit of which at least 6 must be at the graduate level, including

---

-3-

S ?

MBB 802-2 and MBB 806-3. MBB 806-3 must be taken at first opportunity

following two semesters registration in the program.

Research

The major portion of the Ph.D. program will be devoted to original

research. An original Thesis which contributes to new knowledge must be

presented and defended at the end of the degree program in accordance

with SFU Graduate General Regulations.

In addition, all MBB Ph.D.

candidates must present a public seminar on their research.

MBB Graduate Courses

MBB

801-2 Student Seminar in Molecular Biology and Biochemistry I

Discussion of recent literature through student seminars and written

reports. Cannot be taken for credit in addition to CHEM 801.

MBB 802-2

Student Seminar in Molecular Biology and Biochemistry II

Discussion of recent literature through student seminars and written

• ?

reports. Prerequisite: MBB 801 or an M.Sc. degree.

Cannot be taken for

credit in addition to CHEM 802.

MBB 806-3 Ph.D.

Graduate Research Seminar

Oral presentation and defense of a written Ph.D. research proposal.

Students will be examined on their progress and grasp of knowledge

relevant to the proposed research and their capacity to complete the

proposed thesis research. Open only to students in the Molecular Biology

and Biochemistry graduate program. Cannot be taken for credit in addition

to CHEM 806.

MBB 811-1., MBB 812-2, MBB 813-3

Techniques in Molecular Biology and

Biochemistry

Consideration of methods applied to research in molecular, cellular,

and developmental biology; genetics; and biochemistry.

Can be repeated

with permission of the instructor.

MBB 821-3 Nucleic Acids

An examination of recent literature about the structure and function

of DNA and RNA.

MBB 822-3

Biological Membranes

A review of recent literature on the structure, dynamics, function, and

biosynthesis of membrane lipids and proteins.

---

-4-

MBB 823-3 Protein

Structure and Function

Transition state theory; specificity in enzyme catalyzed reactions; use

of recombinant DNA techniques to describe and modify enzyme catalysis,

the function of enzymes in organic solvents, and the development of new

catalytic activities through monoclonal antibody techniques.

MBB 824-3

Physical Biochemistry

The physical properties of biomacromolecules; modern physical

methods applied to biomolecules; properties and analysis of membrane

systems.

MBB 825-3 Bioenergetics

Consideration of important processes for biological energy

transduction. Structure/function relationships of membrane components

and other interacting macromolecular systems.

Cannot be taken for

credit in addition to CHEM 825.

MBB 826-3

Molecular Immunology

An overview of cellular and humoral immunology with emphasis on

the molecular basis of immune recognition and response.

MBB 827-3

Mechanisms in Enzyme Catalysis

The study of enzyme mechanisms by a variety of techniques including

spectroscopic, kinetic, radioisotopic exchange, and site-directed

mutagenesis.

MBB 828-3

Spectroscopic Methods in Biochemistry

Application of spectroscopic methods including multidimensional

NMR, fluorescence, circular dichroism, and FuR for determination of

biomacromolecular structure. Includes elements of protein conformation.

Cannot be taken for credit in addition to CHEM 828.

MBB 829-3

Special Topics in Biochemistry

Consideration of recent literature concerning selected contemporary

research topics. Can be taken more than once with permission of the

instructor.

MBB 831-3

Molecular Evolution of Eukaryote Genomes

Examination of the dynamics of change in eukaryotic nuclear,

mitochondrial, and chloroplast genome structure and organization.

MBB 832-3

Molecular Phylogeny and Evolution

Examination of the basic methods applicable to analyses of molecular

phylogeny and evolution.

VA

---

-5-

• ?

MBB 833-3

Developmental Genetics

Selected topics on the developmental genetics of

Drosophila.

MBB 834-3

Topics in Developmental Biology

Selected topics including pattern formation, morphogenetic

determinants, inductive interactions, and differential gene expression in

embryos.

MBB 835-3

Genomic Analysis

Consideration of topics related to the structure and function of the

genome with emphasis on genome mapping and sequencing projects, and

computational methods for genomic sequence analysis.

MBB 836-3

Gene Expression

A consideration of the mechanisms and regulation of gene expression

in eukaryotes and prokaryotes.

MBB 837-3 Molecular Genetics of Signal Transduction

Consideration of mechanisms of signal transduction using molecular

genetic approaches with emphasis on the yeast

Saccharomyces cerevisiae.

Cannot be taken in addition to BISC 861.

BISC 839-3 Special Topics in Molecular Biology

Consideration of recent literature concerning selected contemporary

research topics. Can be taken more than once with permission of the

instructor.

MBB 871-1,

872-2, 873-3

?

Directed readings in Molecular Biology and

Biochemistry.

Programs of directed reading and critical discussions offered by staff

members to individual students according to their needs. Study programs

must be approved by the MBB Graduate Program Committtee.

MBB 898

?

M.Sc. Thesis

MBB 899

?

Ph.D. Thesis

Courses offered in other SFU Programs

Attention is drawn to CHEM 752-3 Advanced Bio-Organic Chemistry,

CHEM 754-3 Carbohydrate Chemistry, CHEM 811-3 Crystal Structure

Analysis, a

?

BISC 8xx Plant Molecular Biology and Biotechnology, and

BISC 8xx Molecular Biology of Plant Development.

MM

---

Graduate Course Work at other Universities

Upon the recommendation of the Supervisory Committee, and with

the approval of the Graduate Program Committee, up to 6 credits of course

work taken taken elsewhere not resulting in a degree may be applied toward

degree requirements at SFU, but not exceeding more than half of the course

credits required in addition to MBB 801-2, MBB 802-2, and 806-3.

.

L

---

• ?

Proposed Changes to the Calendar under Graduate Science

p

307-308: Delete entire section concerning the Institute of Molecular

Biology and Biochemistry

p.

310: Under the section Biochemistry and Molecular Biology replace the

existing paragraph with:

Students wishing to undertake graduate studies in molecular biology or

biochemistry should refer to the description of the Molecular Biology and

Biochemistry Graduate program in the

Graduate Science

section.

p

312: Under the section Biochemistry replace the existing

paragraph with:

Students wishing to undertake graduate studies in biochemistry should refer

to the description of the Molecular Biology and Biochemistry Graduate

program in the Graduate Science

section.

.

0

---

• ?

Appendix 2

Graduate Program and Molecular Biology and Biochemistry

Relationship of

p ro p

osed courses to existing CHEM and BISC

g

raduate courses.

MBB 801, 802, and 806 are new courses, but in essence replace CHEM 801, 802,

805 and 806 (which will continue to serve Chemistry students)

MBB 811-813 are new courses but will not be given with regularity.

course.

MBB 821, 822, and 823 were previously offered as CHEM 823, a special topics

MBB 824 is a new course; a less sophisticated version has been offered as BICH 424.

MBB 825 replaces CHEM 825.

MBB 826 is a new course.

MBB 827 is a new course.

MBB 828 has been offered as CHEM 824

MBB 829 replaces the special topics course CHEM 823

expanded

MBB 831 and

to two

832

courses.

have been offered as a special topics BISC course, which is being

MBB 833 has been offered as a special topics BISC course.

MBB 834 has been offered as a special topics BISC course

MBB 835 has been offered as a special topics course.

MBB 836 has been offered as a special topics BISC course

MBB 837 has been offered twice as BISC 861

MBB 839 replaces the special topics course BISC 881

MBB 871-873 are new courses, offered in place of Directed Reading courses in CHEM

and BISC. They will be offered infrequently.

Summary: Effectively, four new courses are proposed to be offered on a regular

basis in this graduate program. The addition of six new faculty to the IMBB over the

past 6 years make it possible to mount these courses on the projected schedule.

A tentative four year schedule of MBB courses is attached. Some deviation

may result from sabbaticals etc. The program can be mounted without interfering

. ?

with undergraduate teaching responsibilities in the Biochemistry and Biosciences

programs, which have taken a priority in creating this projected schedule. According

to this schedule 11-13 MBB graduate courses per year would be offered, or

approximately one for each IMBB faculty member.

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---

Appendix 3

Graduate Program and Molecular Biology and Biochemistry

Budgetary Implications for the Library (December, 1994)

After the courses proposed for this new program were compiled,

including lists of serials and books, the cost to the Library for projected

acquisitions was analyzed by Ralph Stanton in his report (Feb. 23, 1994).

He identified a one time cost of $388 for monographs/books and a recurring

cost of $3517 for serials. Of the monographs, the only essential addition is

a $35 book for MBB 832; other books listed by Mr. Stanton constitute

additional copies and/or are not essential, only desirable background

reading. A recent reevaluation of the serials collection by the Faculty of

Science Library Committee resulted in several cancellations,, making possible

the acquisition of most or all of the serials on our required list. It thus

appears that the serials collection is adequate for mounting the proposed

courses.

Our graduate courses rely almost entirely upon the use of recent

literature published in serials. Books and monographs, which are almost

immediately out of date for a course oriented toward current research, are

generally used only for unassigned background reading, and the library

collection is adequate for this purpose (though some of the books are kept

on reserve for undergraduate courses, which may restrict access).

SThe library books and serials collection can thus be described as

adequate. We assume that important books will continue to be added to

the collection as needed (and we are willing to provide guidance in this

respect). We also anticipate that the science serials collection will be

reviewed periodically to ensure that it efficiently serves a broad base of

users whose learning, teaching, and research activities are evolving.

Some MBB courses may need to make use of interlibrary loans,

electronic media, serials loaned by faculty members who hold personal

subscriptions (in particular for back issues of serials not previously held by

the Library), or methods for rapid acquisition of copies of articles from

serials not held by the library.

The Dean of Science has indicated that the Faculty will make funds

available to acquire any essential books and serials not already held.

There will be no further requests for new acquisitions by the library

specifically associated with the courses of the proposed MBB Graduate

Program (most of which have been previously taught). However, the

evolution of these courses and development of new courses may generate

requests for acquisitions in the future.

---

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Molecular Biology and Biochemistry

?

Course Number:_MRR

Title:

Student Seminar in

Mo1ec-iilr T'iinlgv nnd

RjnrhPTn4cry

I

Description:

Students will present seminars and prepare written reports on important

research topics in the current literature.

Credit Hours:

?

2

? Vector:

7-0-0

?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:_in-

15

?

When will the course first be offered:. 53_________________

How often will the course be offered:_

Once per year.

JUSTIFICATION:

• ?

Studentsrecuire experience interpreting, evaluatin g ., and presenting the results

of experiments. A range of topics will be selected to provide a

sampl i

ng of current

research fronts. It will be part of the 1B graduate program.

RESOURCES:

Which Faculty member will normally teach the course:

?

TBA

What are the budgetary implications of mounting the course:

Nrn

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

I

S

•

Approved: Departmental

Faculty Graduate

Graduate

Studies

Studies

Committee:______

Committee:

Faculty:

Senate Graduate Studies Committee:

e:

J//1

ate:

ate: \J t

iS

Senate:

---

MBB 801-2

STUDENT SEMINAR IN MOLECULAR BIOLOGY AND BIOCHEMISTRY I

Instructors:

To be selected from the staff of the Graduate Program in Molecular

Biology and Biochemistry.

Course Format:

Students will present seminars on important research topics in the

recent literature. Topics will be selected from a list suggested by staff and

will vary from year to year. Students will be expected to read literature

related to each topic, write reports on selected topics, and participate in

discussions.

Evaluation:

Students will be evaluated on the basis of the quality of their

seminars, written reports, and participation in discussions.

Comoetence of the Instructors:

The instructors have research expertise and teaching experience in

molecular biology

,

and biochemistry.

Librar y

Resources:

The library serials collection is adequate

0

---

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

?

Molecular Biolo

g

y and Biochemistr y ?

Course Number:

HER fl?.-

Title:

Student Seminar in Molecular Biology Pnd

Binrhinctry IT

Description:

Students will present seminars and

p

repare written reports on impnrtPnt-

research topics in the current literature.

Credit Hours:

?

Vector:_2-0-0

?

Prerequisite(s) if any:

_

fWR

fl1

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

?

10

-15 ?

When will the course first be offered:

95-1

How often will the course be

_-Ye.

offered:

JUSTIFICATION:

Students require experience interpreting.

?

evaluatin

g

,

?

and _presenting

_the _rectlltQ

•

?

of

experiments.

?

A range of topics will be selected to provide a samplinZ

of current

research fronts.

?

It will be part of the MBB

g

raduate program.

RESOURCES:

Which Faculty member will normally teach the course:

_TBA

What are the budgetary implications of mounting the course:

?

None

Are there sufficient Library resources (append details):

?

Ye

Appended: a) Outline of the Course

b) An indication of the competence of the Faculty member to give the

course.

c) Library resources

S

Approved:

Departmental Graduate Studies

Faculty Graduate Studies Committee:_

D

ate: _____________

'-"-' ?

\

oate:

\1I_\

Faculty:

Senate Graduate Studies Commiuee:_

ateI1_-'

Senate:

?

CV

Date_____________

---

MBB

802-2

STUDENt SEMINAR

iN

MOLEcULAR lOLOY

A .

N BiotEMj

g

t'

II

Instrucmrs:

To be selected from the Staff of the Graduate Progarn iti Molecular

Biology and BiOchemistry.

Course Format:

Students will present seminars on important research topics in the

recent literature. Topics Will be selected from a list suggested by staff and

will vary from'

year to yer. Students will be expeoted to read literature

related to each topic, write reports on selected topics, and participate in

discussions.

Evaluation:

StUdenth will be evaluated on the basis of the Oublity of their

seminars, written reports, and participation in

discussions.

Comretence.of the Instructors:

The instructors have research expertiSe àhd t6bdhihg ëxperiêñce in

mOlecUlar biology and biocheh-ilStry.

Librar

y

Resources:

The library serials ibllection is adequate.

LI

Mal

---

Faculty Graduate Studies Committee:

Faculty:

Senate Graduate Studies Committee:

Senate: ?

-

? Dat_

ate:

\'%( \

ate::-''

1 y /

,

SiMON FRASER UNPIERSITY

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

Program:

?

jo.che.misxy ?

______________

Course Number:

_MBB_806

TiUc:_ih,D_._c-radUate Research Seminar

Description:

±.writtefl

research proposal. orI presertatrrn- and defense of the Ph.D.

research project.

Credit Hours:

?

Vector: ?

3-0-0 ?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:_ ?

10 ?

_When will the course first be offered____91

How often will the course be offered:

?

Once per year

JUSTIFICATION:

•

?

The course

is

presented in lieu of a Ph.D. cand1dcy

(qiiaHf)zing) exa

m ?

Tr i11

evaluate thepra.p.oc

ed

th

p

ss

rcrrJprnjaC.t,

ard provide useful prart4re

In grnr

writing, formal presentation of scientific arguients, and defense of one's point

of

view.

It will be part of the ?B graduate program.

RESOURCES:

Which Faculty member will normally teach the course

?

TBA

What are the budgetary implications of mounting the course:

?

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:_

.

---

MBB 806-3

Ph.D. GRADUATE RESEARCH SEMINAR

Instructors:

Two or three instructors will be selected each year from among the

staff of the Graduate Program in Molecular Biology and Biochemistry. In

addition, the members of the Graduate Supervisory Committee for each

student will be present as examiners.

Course Outline:

Each student will prepare a written proposal of Thesis Research using

the format of the NSERC Grant Application Form. The proposal should

include a statement of the goals for the research program a review of the

most significant literature related to the research topic, a summary of

research progress, and a description of the proposed research, including a

consideration of the methods to be used. The student will present a

seminar on the proposed thesis research project, and will be examined by

the course staff. Students enrolled in the course will attend the

seminar/examination and may participate in the questioning.

Evaluation:

This course is offered in lieu of a candidacy exam. Failure to pass

this course will result in withdrawal from the program. Students who do

not initially pass this course may be granted an Incomplete grade and given

a second opportunity to pass the course within an agreed period of time.

Evaluation will be based on the student's capacity to effectively

communicate concerning the subject matter of the proposed Thesis

Research, the grasp of knowledge relevant to the proposed research, and

the capacity to complete the proposed program of Thesis Research.

Competence of Course Staff

The instructors will be selected to represent a broad view of

molecular biology and biochemistry. Members of the Graduate Supervisory

Committees are selected on the basis of their expertise in the area of

proposed research.

Library

Resources:

Library resources are adequate. Studeçits may need to use other

resources to obtain all the pertinent literature related to their research topic.

S

0

---

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

_Molecular Biolog

y

and Biochemistr

y

?

Course Number:MBB 811, 812, 813

Title: Techniques in Molecular Biolo

gy

and Biochemistry

Description: Practical experience in current methods used in molecular biolo

gy

and

biochemistry.

Credit Hours: 1. 2, 3, respectively Vector:QO,-9

?

Prerequisite(s) if any:

?

None

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: ?

3-10 ?

When will the course first be offered: TBA

How often will the course be offered: _Intermittentl

y

,

_asneeded.

JUSTIFICATION:

The three courses allow the rapid mounting

of

courses

(of

appropriate credit weieht)

considering important new methods as they emerge or established methods

of

broad

utilit y . ?

It will

be part of

the MB

g

raduate program.

RESOURCES:

Which Faculty member will normally teach the course:

?

TEA

What are the budgetary implications of mounting the course:

None _

at_presenr._In

_future.

acauisjtion

of a pp ro p

riate equipment might be required.Supplies

will beprovided

through funds from the IMBB operating budget.

Are there sufficient Library resources (append details):

?

Yes.

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:

?

72/,,/g_?

Faculty Graduate Studies Committee:_ Date:

_____________

Faculty:_-_

?

-

Date:

VW

Senate Graduate Studies Committee:-'b

?

-

?

Date: ?

)L_

1-

Senate: ?

DateV

.

---

MBB 811-1, 812-2, 813-3

TECHNIQUES IN MOLECULAR BIOLOGY AND BIOCHEMISTRY.

Instructors:

Will be selected from among the staff of the Molecular Biology and

Biochemistry Graduate Program.

?

-

Outline:

These courses will offer laboratory training in specific specialized

techniques. Possible topics will include methods applied to contemporary

research in molecular, cellular, and developmental biology, genetics and

biochemistry, including laboratory demonstrations, hands-on exercises, and

computer workshops. Course content will depend on student demand and

opportunities provided by the development of important new technologies.

Scheduling will depend on availability of appropriate laboratory space and/or

facilities. Courses will be offered during all or part of a semester, but

usually as an intense but short course having appropriate credit weighting.

The course can be repeated with permission of the instructor.

Com

p

etence of the Instructor:

The instructor offering the course would be one experienced with the

techniques.

Library Resources:

The library resources are adequate for offering these courses.

---

•

Approved:

Departmental Graduate Studies Commi

Faculty Graduate Studies Committee:_

Faculty:

Senate Graduate Studies Commi

Senate: ?

'S ?

Date:____________

ate:

ate: _

\'

1t

ate:

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

Proaram:

?

• ?{olecular Biology and Biochemistr

y ?

Course Number:

MBB 821-3

Title: ?

Nucleic Acids

Description:

An examination of recent literature for revelations about the structure and

function of DNA & RNA, drawing on a variety of chemical, biochemical and molecular biolo-

gi

cal

H

perspectives.

Credit ours:

?

3 ?

Vector:

3-0-0 ?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: _8_

-

_10—When will the course first be offered:

?

961

How often will the course be offered:

Tre

every

three

years

JUSTIFICATION:

•Nucleic- r-- -

?

It will be part of the ?

B

g

raduate Program.

acids are crucial elements of the genetic structure and function of all

cells. Familiarity with nucleic acids is required for all:môleulár biologists and

biochemists engaged in genetic manipulations. Replaces CHEM 823, Special Topics.

RESOURCES:

Which Faculty member will normally teach the course: ?

Dr. Dipankar Sen

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

Yes. Two textbooks recommended for the

Appended: a) Outline of the Course ?

course are kept on reserve.

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

---

A) ?

Outline of the course:

MBB821-3 ?

NUCLEIC ACIDS

The course will be conducted as a combination of lectures by the instructor and

short presentations on current research papers by individual students.

The following topics will be covered:

1.

Sugars, bases, and nucleotides

2.

DNA structure

3.

Chromatin

4.

DNA superhelicity

5.

RNA structure

6.

RNA - ligand interactions

7. Catalytic RNA

8.

DNA - ligand interactions

•B) Instructor's competence:

Dr. Sen received training in nucleic acid biochemistry at Yale and Harvard

Universities. With Nobel laureate Walter Gilbert he published several seminal

papers on DNA structure and function in the leading journals

Nature

and

Biochemistry.

His current research continues to focus on novel structures of

nucleic acids and their function, as well as chromosome structure and function.

He has taught this course twice previously as a very popular special topics

course (CHEM 823).

C) Library resources:

The library resources are adequate. Copies of the text books are already

placed on reserve when the course is offerred. They are "Principles of Nucleic

Acid Structure" by Wolfram Saenger (Springer Verlag) and "Nucleic Acids

Chemistry and Biology" by G.M. Blackburn (IRL Press). The essential journals

are already part of the collection.

0

---

I

SIMON FRASER UNiVERSITY

?

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

o ram:

Molecular Biolog

y

and Biochemistry

?

Course Number:MBB

872-1

Title: ?

Biological Membranes

Description:

Survey of recent literature on the structure, dynamics. function, and

biosynthesis of membrane proteins and lipids.

Credit Hours:

?

3

?

Vector: 3-0-0

?

Prerequisite(s) if any:

....Permission _of

Instructor.

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: ?

1OWhen will the course first be offered:

?

96-1

How often will the course be offered:_.

_T7iceevery threeyears.

JUSTIFICATION:

•

?

Rpia.

aces CHEM8:23i.Spèciàl

Tikcs

Will_be_ part

_of_ the

_MBB_ g raduate

_program.

Biologicalmembranessurroundallcellsandhaveessentialroles _in_

the _structure .

function, organization, and communication of cells. The courseconcernsoneof

topics of research focus of the MBB Graduate Program..

RESOURCES:

Which Faculty member will normally teach the course:

?

Dr. _

R.B.

_Cornell

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

•

Approved:

Departmental Graduate Studies Committee:

Faculty Graduate Studies Committee:

?

Date:

Faculty: ?

j ?

Date:

\

I'

I

Senate Graduate Studies Committee:-

_Q(_-

21,

_ate:::/

Senate: ?

Date______________

---

MBB 822-3

.

BIOLOGICAL MEMBRANES

Instructor:

?

A. Cornell

Prere q

uisites: ?

Permission of instructor

Re q uired Text: ?

Biomembranes, by Robert Gennis

I. MEMBRANE STRUCTURE AND DYNAMICS

CHAPTER IN GENNIS

A.

Diversity and similarity in biological membranes

?

1

- Membrane Models

- Membrane Composition

B.

Thermodynamics of micelle/membrane assembly

?

2.3

- The hydrophobic effect

C.

Lipid polymorphism ?

2

- Determinants of micelle size and shape

- Lipid polymorphism and the regulation of membrane

lipid composition ?

(10.5)

D.

Phospholipid structure from crystals

?

2.1

E.

Phase transitions of pure lipids and lipid mixtures

?

2.2

- Influence of acyl chains

?

2.4

- Influence of polar head groups

- Effects of pH, cations, cholesterol

- Phase separations

F. Phospholipid dynamics

?

5

- Spectroscopic methods for characterizing the

interior of the bilayer.

G.

Rotational and lateral diffusion rates of lipids and proteins

?

5

- Implications for protein-protein interactions

H.

Lipid Asymmetry and Trans-bilayer Flip-flop

?

4

I.

General themes in the structure of membrane proteins

?

3

- Classification

- Predictive algorithms for topography

- Crystal structures

J.

Domains in Membranes

?

4

Lipid and protein

?

0

3:.

LI

---

I

.

II. LIPID-PROTEIN INTERACTIONS

A. Covalently Bound Lipid

B.

Lipid boundary layers

- Conflicts and resolution of NMR and ESR data

2

CHAPTER IN GENNIS

3.8

5.5

C. Solubilization, Reconstitution and Purification of Membrane

proteins

D. Enzyme requirements for specific lipids

?

6

- Acetylcholine receptor

- Cytochrome oxidase

- Cytidylyltransferase

E. Model systems for studying lipid-protein interactions -

amphiphilic peptides and liposomes

Ill. TRANSPORT OF SMALL MOLECULES AND

IONS THROUGH MEMBRANES

?

8

A. Thermodynamics of Transport. ?

Categories of transporters.

C

B. Channel structure and function exemplified

by

K+

channel.

C.

ATPase ion pump structure and function.

IV. MEMBRANE BIOGENESIS

A.

Mechanism of protein translocation across membranes

during biosynthesis ?

10

- Thermodynamic models ?

10.1 - 10.3

- Signal Hypothesis

B. Requirements for Protein Translocation:

- Signal Peptides

- Unfolded conformation

C.

Regulation of membrane lipid synthesis and transport

?

10.4

-

E. coil,

yeast, mammalian cells

V. ROLE OF PLASMA MEMBRANES IN SIGNAL TRANSDUCTION

?

9

.

A.

Receptors - classification and characteristics

B.

Membrane lipids involved in signal transduction

- PIP

2

metabolism (inositol-P signaling system)

- Diacyiglycerol, modulation of protein Kinase C

- PC metabolism

VI. REPORTS FROM STUDENTS

-

?

9.7, 9.8

9.73

3,

---

N V 3

8 ''2-2

Com

p

etence of Instructor:

Dr. Cornell received graduate and postdoctoral training in the biochemistry of lipids

and membranes at U. Pennsylvania, UBC, and U. Toronto. She has published in

leading journals on membrane structure, lipid-protein interactions, and signal

transduction mediated by phospholipids; she has given many invited lectures. Her

research is supported by the Medical Research Council, for which she has served as a

member of a grant selection committee. Dr. Cornell has taught courses 4 times as a

special topics course (CHEM 823).

Library

Resources:

The library resources are adequate.

.

Oq

---

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Program:

Molecular Biology and Biochemistr

y

?

Course Number:

MBB_823-3

Title: ?

Protein Structure and Function -

Recent research in transition state theory; specificity in enzyme catalyzed

Description:

reactions, the use of recombinant DNA techniques to describe and modif

y

_enzyme

catalysis, the function of enzymes in organic solvents, and the development of new

catalyticactivitiesthroughmonoclonalantibodytechniues.

Credit Hours: _3

?

_Vector:_3-p-0

?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: 5-10

?

—

When will the course first be offered:__:

How often will the course be offered:

_ Once per year

JUSTIFICATION:

The course focuses on recent exDerimental approaches to understanding the structure

and function of proteins, esDeciallv enzN-mes. This is a focus of research activity in

the IMBB.It complements NEB827. Cannot be taken for credit in addition toBICH423.

It will be part of the MBB graduate program. Previously taught as a special topics course

RESOURCES:

Which Faculty member will normally teach the course:

_Dr. Thor Borgford

What are the budgetary implications of mounting the course:

?

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:

0 ?

Faculty Graduate Studies Committee:

Faculty:

Senate Graduate Studies Committee:

?

>_(_i-e_-------..---Da

Senate: ?

Da

te:

'U

I

f

p. /'-' /

/ ?

7 )

---

4

?

*

a)

Outline of the course

MBB 823-3 ?

4

PROTEIN STRUCTURE AND FUNCTION

Instructor: ?

T. Borgford

Course description:

?

This course is designed to familiarize students with

current topics in the study of protein (enzyme)

structure and function. Lectures will involve

discussion of recent publications in the subject

areas, in which all students will be expected to

participate.

Course outline: ?

Topics to be covered will include:

Transition state theory

The nature of specificity in enzyme catalyzed

reactions

The use of recombinant DNA techniques to

describe and modify enzyme catalysis

The function of enzymes in organic solvents

The development of entirely new catalytic

activities through monoclonal antibody

techniques (Abzymes).

Course evaluation: ?

Grades will be based on 5 written assignments and

?

one classroom seminar.

b)

Competence of instructor

• ?

Dr. Borgford received training in protein biochemistry and use of site

directed mutagenesis for protein engineering at U. Manitoba, U. Alberta, and

Imperial College, London. He has published in leading biochemistry journals

and leads a large contractual research team engaged in genetic engineering

of proteins. His research expertise is directly related to the topics of this

course. He has taught this course several times previously as a special

topics course.

c)

Library resources

Library materials are adequate and no additional requirements are

anticipated at this time. On-line databases of protein structural information

will be used.

I-/I

---

.

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Program:

Molecular Biology and Biochemistry

?

Course Number:

:

MBB 824-3

Title: ?

Physical Biochemistry

Description:

The physical properties of biomacromolecules and their use in determining

molecular weight and conformation; modern physical methods applied to biomolecules;

properties and anal

y

sis of membrane systems.

Credit Hours:

?

3 ?

Vector: 3-0-0

?

Prerequisite(s) if any:

CREM_261._BICH_321

(or BICH 301) or equivalent (see instruct

S

.

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

_5_ grad s

_

When will the course first be offered:

?

96-3

How often will the course be offered:

_Every _two _years

JUSTIFICATION:

For graduate students lacking an introductory course in physical

biochemistry.

Cannot be taken in addition to BICH 403-3.

?

It will be p

art of the MBB

g raduate progr m.

This introduction to ph

y

sical biochemistr y

is for students who do not

have the

equivalent of BICH 403, an essential course for all biochemistry students.

RESOURCES:

Which Faculty member will normally teach the course:

_Dr. R.J.Cushley

What are the budgetary implications of mounting the course:

?

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b) An indication of the competence of the Faculty member to give the course.

c) Library resources

Approved:

Departmental Graduate Studies Committee:________________________

Faculty Graduate Studies

_

Committee:

Date: _____________

<

Faculty:__"

?

->')

Date:

19-S

-

Senate Graduate Studies Committee:

Date-

L/Q?

Senate:

---

a) Outline of

the course

MBB 824-3

?

.

PHYSICAL BIOCHEMISTRY

Instructor:

?

Dr. R.J. Cushley

Prerequisites:

?

CHEM 261, BICH 321 (or BICH 301) or equivalent (see

instructor).

Course Description:

?

Section 1 - Physical Properties of Biomacromolecules

Thermodynamic Review

Solution Thermodynamics

Irreversible Thermodynamics

Phenomenological Theory

Diffusion

Hydrodynamics

Electrophoresis

Section 2 - Physical Methods (Structure and

Conformation of Biomacromolecules)

Light Scattering

ORP/CP

Laser Raman

Intensity Fluctuation

Fluorescence Spectroscopy

NMR

One tutorial per week will be given and will cover

review and update of related topics (e.g.,

thermodynamics,

,

mathematical methods), problem sets

and demonstrations appropriate to the subject matter.

Textbooks: ?

Biophysical Chemistry. Part II: Techniques for the

Study of Biological Structure and Function, C.R. Cantor,

and P.R. Schimmel, W.H. Freeman & Co. Publishers,

1980, ISBN 0-7167-1190-7 - Required.

and

Physical Biochemistry, 2nd Edition, K.E. Van Holde,

Prentice-Hall Publishers, 1985, ISBN 0-13-666272-2 -

Required.

Mark Distribution: ?

Midterm Examination

?

30%

Final Examination ?

70%

.

.

L1

---

C

b)

Competence of the Instructor

Dr. Cushley was trained in physical biochemistry and organic chemistry in

a leading Canadian research group at U. Alberta, did research at Sloane Kettering

Institute and Cornell, and served on the Faculty at Yale University. He has an

extensive publication record based on the use 'of physical biochemical methods to

investigate biological macromolecules. His particular research expertise is with

spectroscopic methods, especially high field nuclear magnetic resonance. A

recent sabbatical increased his expertise in 3-D NMR analysis.

c)

Library resources

The library collection is adequate.

0

---

Approved: Departmental Graduate Studies Committee:

.

Faculty Graduate Studies Commi

Faculty:

Senate Graduate Studies Commi

Date: ?

/ I2

Date:(

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Molecular Biolo

gy

and Biochemistry ?

Course Number:MBB

825-3

Title: ?

Bioenergetics

Description: Consideration of important processes for biological energy transduction.

Structure/function relationships of membrane components and other interacting macro—

molecular systems.

Credit Hours:

?

Vector:

1-n-0

?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: ?

5-10 ?

\Vhen will the course first be offered:

?

96-1

How often will the course be offered: Once every two years

JUSTIFICATION:

This course is a re—designation of

CHEM 825-3,

which will be dropped. The latter

course has been offered wanv times b

y

the Chemistry Department (the last time in 92-11

with good enrollments. It will be part

of the MBB graduate

progrP11.

RESOURCES:

Which Faculty member will normally teach the course: Dr. W.R. Rchrdc

What are the budgetary implications of mounting the course: _None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Senate:

---

MBB 825-3

BIOENERGETICS

Instructor: ?

Dr. W.R. Richards

Course descriDtion: ?

Consideration of important processes for biological

energy transduction. Structure/function reIatiohships of

membrane components and other interacting

macromolecular systems.

Course outline:

?

Specific topics will include:

1.

Introduction and review of membrane structure and

principles of bioenergetics.

2.

The nature of the "energized state" Of biomembranes

and mechanisms for the formatiOn of ATP during

electron transport reactions.

3.

Bacteriorhodopsin: The "photo-activated-proton-

pump" of Halobacteria.

4.

Bacterial and greenpiant photosynthesis.

5.

Attempts to construct an artificial biological "solar

battery."

6.

Mitochondrial oxidative phosphorylation,

mitochondrial inner membrane transport systems, and

thermogenesis.

7.

Bacterial electron transport chains, cytoplasmic

membrane transport systems, motility, chemotãxis,

and phototaxis.

8.

Eukaryotic membrane transport systems, including

cytoplasmic membrane, sarcoplasmic reticulum, and

neural membranes (nerve impulse transmission).

Competence of the Instructor:

Trained in protein biochemistry and biophysics at the University of

California, Prof. Richards carries out research on eznymes involved in energy

transduction in photosynthetic bacteria and plants and publishes in leading

biochemistry journals. He has taught this course as CHEM 825 several times.

Library resources

The collection of books and serials continuesto be adequate

for this biochemistry course.

qb

---

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

Molecular Biology and Biochemistry

?

Course Number:

_MBB 826-3

Ti

t

le: ?

mo

lec

ular Immunology

An overview of cellular and humoral immunology with emphasis on the molecular

Description:

basis of immune recognition and response. Areas to be covered: (i) the organi-

zation of the immune system, (ii) B-cells and the antibody response, (iii) T-cells and the

control of the immune response, and (iv) the diversit

y

of the immune response, including

immunity to pathogens, hypersensitivity, autoitnmunitY and tissue transplantation.

Credit Hours:

?

3 ?

Vector:32_-O

?

Prerequisite(s) if any:

BICI-1322 and BISC 3:

or equivalent.

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

?

10 ?

_\Vhen will the course first be offered:_

-.

How often will the course be offered:

?

Every year

JUSTIFICATION:

A course in immunology should be available in any undergraduate

or graduate program

• ?

in biochemistry, molecular and cell biology.

?

It will be part of the 1

, MB graduate

program.

RESOURCES:

Which Faculty member will normally teach the course:

?

Dr

-

?

Ttie 1.

?

Scott

What are the budgetary implications of mounting the course: _

minimal

Are there sufficient Library resources (append details):

?

(enr11y ?

eqii.te

two journals is

hnt the

additionf

strongly recommended.

Appended: a) Outline of the Course

b) An indication of the competence of the Faculty member to give

the course.

c) Library resources

Approved:

Departmental Graduate Studies Committee:_

Faculty Graduate Studies Committee:

Faculty:_

'- _

Senate Graduate Studies Committee.

Senate:

( ?

Date:

-iDate:

----Date-14"

?

/

Date:

---

a) Outline of the Course

MBB826-3

?

S

MOLECULAR IMMUNOLOGY

Instructor: Jamie K. Scott

Course descriDtion: An overview of cellular and humoral immunology with

emphasis on the cellular and molecular bases of immune recognition and

response. Areas to be covered include (I) the organization of the immune

system, (ii) B-cells and the antibody response, (iii) T-cells and the control of

the immune response, and (iv) the diversity of the immune response,

including immunity to pathogens, hypersensitivity, autoimmunity and tissue

transplantation. The course will comprise three hours of lecture and one

hour of student presentations of articles from the literature each week.

Course outline:

A. ?

The organization of the immune system

1.

The anatomy and physiology of the lymphoid organs

2.

Cells of the lymphoid system

3.

Effector molecules of the immune system

4.

Diversity of the immune response

5.

Ontogeny of the immune system

B. ?

B-cells

and the antibody response

1.

Antibody structure, function and genetics

2.

B-cell differentiation and the humoral immune response

3.

B-cell ontogeny

C.

?

T-cells and the control of the immune response

1.

The structure, function and genetics of 1-cell receptors and

major histocompatibility antigens

2.

1-cell differentiation and the cellular immune response

-

3.

?

1-cell ontogeny and the development of self vs non-self

recognition

D.

?

The diversity of the immune response

1.

Immunity to viruses, bacteria and parasites

2.

Hypersensitivity reactions

3.

Autoimmunity

4.

Tissue transplantation and graft rejection

b) Competence of the Instructor

Dr. Scott received Ph.D. training in molecular biology and

immunology. She then completed an M.D. degree and returned to

postdoctoral research in molecular immunology. With her mentor, she

invented the technology for producing and utilizing phage display epitope

libraries for a broad range of biomedical research problems, such as vaccine

Iff

---

. ?

development. She has given many invited lectures on this subject and

collaborates widely in her research. She serves on a grant selection

committee for the National Cancer Institute.

c) Library Resources.

The library holdings are adequate for the most part. The instructor will

make available copies of papers from her personal collection. Over a period

of time, the collection of serials should evolve to better represent the

biomedical sciences, a primary area of research activity for biochemists and

molecular biologists, but no further additions to the collection are essential

for this course.

.

.

'19

---

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

ProRram:

?

Molecular Biolog

y

arid Biochemistr

y

?

Course Number:

_MBB 827-3

Tide:

?

Mechanisms in Enzyme Catalysis

Description:

The stud

y

of enzvtne tnechans'.S b

y

a variet y

of techniques including spectro-

scopic, kinetic, radioisotopic exchange, and site-directed mutaenesiS. The participation

of coenz

y me

S

and amino acid functional groups in enz

y

me catalysis.

Credit Hours:

?

3

_Vector:_3°0— Prerequisite(s) if any: 96-3

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

?

When will the course first be

.

offered:

How often will the course be offered:

i

_once _every_two _years

JUSTIFICATION:

This course will examine enz

y

me mechanisms at an advanced level. It

?

PT-

n.

5

?

M3B 823, focusing on kinetic ap

p

roaches to investigatin

g

enz-me function,

Tr

w

ill

I-l

e

part of the Y3B graduate prop-rain.L part of the focus on protein . structure and funct on.

RESOURCES:

Which Faculty member will normallyteach the course:_W.R.

_RichardF._

T.J._Borgfnrd

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Comttee:

Faculty Graduate Studies Committee: _..Date:_

Faculty: ?

.

?

flte

Senate Graduate Studies Comrnittee:?"_L_-_----

_

i14tc.,rt

Senate:

n

---

a)

Outline of the course:

MBB 827-3

MECHANISMS IN ENZYME CATALYSIS

Instructor(s): ?

W.R. Richards, T.J. Borgford

Course descri

p tion:

?

The study of enzyme mechanisms by a variety of

techniques including spectroscopic, kinetic,

radioisotopic exchange, and site-directed

mutagenesis. The participation of coenzymes and

amino acid functional groups in enzyme catalysis.

Course outline:

?

Specific topics will include:

1.

The study of enzyme mechanisms by kinetic

techniques: ?

Pre-steady state

versus

steady

state kinetics. ?

Sigmoidal kinetics and allosteric

2.

enzymes.

Fast reaction kinetics: stopped-flow,

continuous-flow, and quenched-flow methods.

Relaxation kinetics: temperature-jump and

pressure-jump methods.

3.

Methods of detection of enzyme-catalyzed

reactions: spectroscopic and isotopic exchange

methods.

4.

Active-site directed and enzyme-activated

irreversible inhibitors: affinity labels and suicide

inhibitors.

5.

Substrate binding and enzyme-substrate

complementarity: transition state analogues

and abzymes.

6.

Examples of enzyme mechanisms. The

participation of coenzymes and amino acid

functional groups in enzyme catalysis.

?

The

stereochemical specificity of enzyme action.

7.

The use of site-directed mutagenesis in the

study of enzyme mechanisms.

b) Competence of the Instructor

Dr. Richards is a protein biochemist who has taught enzymology

(BICH 412) several times. He has research expertise on purification and

kinetic reaction mechanisms of enzymes and the use of photoaffinity labels.

Dr. Borgford's research interests include mechanisms of enzyme catalysis.

His experimental approach, using protein engineering techniques,

complements the more traditional purificationand kinetic approaches to

enzymology of Dr. Richards. This new course will benefit from the

complementarity of expertise of the two instructors.

.

.

51

---

c) Library resources

The library collection is adequate. It will be supplemented by

personal subscriptions and the use of on-line databases.

.

0

---

Approved: Departmental Graduate Studies Committee:_.fVAt7

.

Faculty Graduate Studies Committee:

ate: -

te•

kV

.<AJ—,

Faculty:

Senate Graduate Studies Committee: ' _\_

Senate:

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Prograin

Molecular Biology

v and Biochemistr

y ?

Course Number: _MBB

828-3

Tide: ?

Spectrosco

p i

c

Methods in Biochemistry

AplicatiOfl of spectroscopic methods including multidimensional NR, fluorescenc

Descripuon: circular dichroisi

p

. and FTIR for determination of biomacromolecular structure.

Emphasis will be on the determination of protein structure. Includes elements of protein

formation. e.g.. secondary motifs. predictive methods, epito

p e ma

pp in g

and protein foldi

Credit Hours:

?

3 ?

Vector:Q-0 ?

Prerequisite(s) if any:

BICH403

or

824

or equivalent

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: _5

—

When will the course first be offered:

How often will the course be offered: Every two years

JUSTIFICATION:

Replaces CHEM

824-3.

Course title better reflects course content, which emphasizes

application of spectroscopic nethods. M

ID

824-3 serves as a broader introduction to

physical biochemistr

y

. It will be part of the

KRB g raduate

prngra,part

of the

focus

on protein structure and function.

RESOURCES:

Which Faculty member will normally teach the course:

?

Dr. R.J. Cushley

What are the budgetary implications of mounting the course: None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

---

a) Outline of the course

MBB828-3 ?

0

SPECTROSCOPIC METHODS IN BIOCHEMISTRY

Instructor: ? Dr, R.J. Cushley

Course descrirtion: ?

Application of spectroscopic methods including

multidimensional NMR, fluorescence, circular

dichroism, and FTIR for determination of

bioniacromolecular structure. Emphasis will be on

the determination of protein structure. Includes

elements of protein conformation, e.g., secondary

motifs, predictive methods, epitope mapping and

protein folding.

Course outline: ?

I. Protein Structure

1.

Elements of protein structures

2.

Prediction of protein secondary structures -

Chou-Fasman, hydrophobic moments, etc.

3.

Epitope mapping

4. Protein folding

II. Spectroscopic Methods

1. ?

Multidimensional NMR

a)

Chemical shifts and scaler interactions

b)

Relaxation processes

c)

Nuclear Overhauser effect

d)

Resonance assignments and structure

determination

e)

Distance geometry, simulated annealing,

RMA

f)

"Nuts and Bolts"

g) New advances

2.

?

Fluorescence (if time permits)

a)

Fluorescent probes and protein and

nucleic acid structure

b)

Rotational correlation times

3. Circular dichroism and FTIR (if time permits)

b) Competence of the Instructor

Dr. Cushley was trained in physical biochemistry and organic

chemistry in a leading Canadian research group at U. Alberta, did research

at Sloane Kettering Institute and Cornell, and served on the Faculty at Yale

University. He has an extensive publication record based on the use of

physical biochemical methods to investigate biological macromolecules. His

IWO,

---

a ?

p

particular research expertise is with spectroscopic methods, especially high

field nuclear magnetic resonance. A recent sabbatical increased his

expertise in 3-D NMR analysis. He has taught this course previously.

c) Library resources

The library collection is adequate.

.

.

---

SIMON FRASER UNP/ERSITY

?

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

Molecular Biology and Biochemistry

?

Course Number: _MB 829

Tide:

Special Topics in Biochemistry

Description:

A detailed consideration of selected contemporarY research to

p

ics in

biochemistry.

Credit Hours:

?

3 ?

Vector: ?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: 5 - 10

?

When will the course first be offered: IBA

How often will the course be offered:

Intermittentl

y

, as recuired.

JUSTIFICATION:

. ?

This course provides an o

p

portunity to cuicklv mount a new graduate course in an

emerging research front or in accordance with special opportunities, such as the

• ?

arrival of a new faculty member. It will be

p

art of the MBB

g raduate program.

RESOURCES:

Which Faculty member will normally teach the course:

?

TRA

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

is

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Faculty Graduate Studies Committee:

?

Date:

Faculty: ?

_ ?

kk1/2

,KQJr.L-,_\ ?

Date:

Senate Graduate Studies Committee:

In

Th

S

Aonroved: Denartrnental Graduate Studies Committee:

Senate:

---

MBB 829-3

SPECIAL TOPICS IN BIOCHEMISTRY

Instructor:

To be selected from among the staff of the Graduate Program in

Molecular Biology and Biochemistry.

Outline:

A detailed consideration of recent literature concerning important

contemporary topics in biochemistry and related disciplines. Topics will

change from year to year, and this course can be taken more than once

with permission of the instructor. The topics will not be covered in depth in

other MBB graduate course offerings. This course allows an opportunity to

quickly provide graduate instruction in newly developing areas of research

or in response to special circumstances, such as the presence of a new or

visiting faculty member. The instructor(s) will decide on the format of the

course, with the approval of the MBB Graduate Program Committee.

Comoetence of the Instructor:

The course will be offered by an Instructor having research expertise

or specialized knowledge in the topic covered.

Librar y

Resources:

The books and serials collection of the library are adequate.

.

0

---

Approved: Departmental Graduate Studies Committee:

Faculty Graduate Studies Commi

7,/_

.

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Program:

?

MB

?

Course

Number: _83 1-3

TiUe:_l1olecu1ar Evolution of Eukar

y

ote Genomes

Description: Examination of the dynamics of chan

g

e in eukar

y

otic nuclear, tnitochondrjal,

and chlorolast genome structure and organization including mechanisms of gene conversion,

transposition, and duplication.

Credit Hours:

?

3

?

Vector: 3-0-0

?

Prerequisite(s)

if

any: Graduatestanding

in cell or molecular biology or per-

mission of the instructor.

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: -_15_When will the course first be offered: 971

-

How often will the course be offered: In alternate years, to alternate with MBB532.

JUSTIFICATION:

The organization of eukarvote Renomes has been molded over evolutionar

y hist or

y

by a

variety_ofgeneticprocesses,includinggeneduplication,geneconversion,transposition

of mobile elements. In order to understand how genomes function, it i2 essential to

examine the processes involved in their evolution. It will be part of the MBB graduate

Program.

RESOURCES:

Which Faculty member will normally teach the course:

?

pen-h,_Trith

What are the budgetary implications of mounting the course: None, the course will dependonthe

primarymolecularbiologyandevolutionliterature.BeckenbachandSmithhavealready

offered similar courses as special topics.

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Faculty:

?

flt

Senate Graduate Studies Commi

---

a) Outline of the Course

MBB831-3 ?

S

MOLECULAR EVOLUTION OF EUKARYOTE GENOMES

I. Nuclear genomes

A. Characteristics of its organization

i.

Exons, introns, regulatory elements and non-coding regions.

ii.

Clustered and dispersed repetitive DNA.

iii.

Satellite DNA, telomeres and pairing regions

iv. Transposable elements

v.

X-Y chromosome differentiation

B. Dynamics of change

i.

Gene duplication

ii. Concerted evolution

iii. Exon shuffling

iv. Origin of introns

v.

Transposition of mobile elements

II. Mitochondrial genomes

A. Organization of animal and plant mitochondrial genomes

B. Mechanisms of change

i.

Point mutations

ii.

Gene rearrangements

C. Mathematical models of gene organization changes

Ill. Chloroplast genomes

A. Organization and gene content

B. Mechanisms of rearrangement

C.

Transcription and RNA edition--evidence and mechanisms

IV. Nucleo-cytoplasmic interactions

A. Genetic interactions

B. Transfer of gene functions from organellar to nuclear genomes

b) Competence of Faculty:

Both listed faculty have been publishing internationally recognized research

in the area of molecular evolution for over 10 years. They have both been

elected as Associates in the prestigious Program of Evolutionary Biology of the

Canadian Institute of Advanced Research, have organized national symposia in

the area of molecular evolution, have presented numerous papers on this topic at

international meetings, and routinely review primary research publications for

journals such as Genetics, J. Molec. Evolution, Molecular Biol. & Evol. and

others.

c) Library Resources:

Present library resources, e.g., primary journal sources, review sources,

etc., are adequate for this course.

n

'No

---

I

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

is

CALENDAR INFORMATION:

?

MIBB ?

Course Number:

817-1

Title:

Molecular Phylogeny and Evolution

Examination of the basic methods applicable to detailed analyses of molecular

Description:_

phylogenv

and evolution includin

g

discussions of cladistic vs. distance nethod

tree construction and analysis, and the choice of appropriate molecular sequences for

na1yic

of various 1v1s of divergenre.

Credit Hours:

?

3 ?

Vector: 3-0-0

?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

5

-

12

When will the course first be offered:_

How often will the course be offered:

_Alternate years

JUSTIFICATION:

Molecular phylogenv and evolution represent important new applications of molecular

biology and are a focus of research efforts in the

MBB

g

raduate program. A similar course

has been offered as a Special Topics course, which will now be formalized and regulajy

scheduled. It will be part of the

KBB

graduate program.

RESOURCES:

Which Faculty member will normally teach the course:

_M.J.

Smith and A.T. Beckenbach

What are the budgetary implications of mounting the course:

_None

Are there sufficient Library resources (append details): _X

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

'I/J__1

ate:_/.

2//,/

/

/,

c,

-

Approved: Departmental Graduate Studies Committee:

Faculty .

Graduate Studies Committee:

?

hate:______________

Faculty:

?

Date: ?

)

9S

Senate Graduate Studies Committee:

?

_

Date: _)2YI

Senate: ?

Date;

---

a) Outline of the

Course

MBB832-3 ?

.

MOLECULAR PHYLOGENY AND EVOLUTION

The course will consist of faculty lectures and student seminars. Students

will be expected to become conversant with the classical and contemporary

literature in molecular evolution.

LECTURE/SEMINAR AREAS:

1) DNA and protein structure and sequence.

2) Sequence alignment algorithms.. .character weighting and gap penalty

assignment.

3) Molecular clocks and rate constance hypotheses.

4) Mutations, pathways and mechanism of change, transition to

transversion pathways, rations, and rates.

5) Protein evolution: amino acid changes:,

Codon families, synonymous versus non-synonymous nucleotide

changes;

Measures of homology and divergence:

?

PAM and BIOSUM matrices

6) Construction of phylogenetic trees and the discernment of descent

Cladistic methods...

Distance methods...

7) Genome structure and characteristics:

Organellar genomes

Chloroplasts

Mitochondrial genomes

Nuclear genomes:

Repeated sequences, micro- and minisatellites,

introns, exons, and genes.

8) Methods and approaches:

A) Choosing the right macromolecule

1)

Ribosomal genes, peptide coding genes, tRNAs,

introns, exons, satellites.

2)

Mitochondrial, chioroplast, or nuclear genome.

B) Methods:

1)

PCR, RAPDs, VNTRs, and Fingerprinting;

2)

DNA sequencing

•

?

3) RFLP analyses

9) Introduction to computer methods:

A)

Computer data bases:

e.g., EMBL, GenBank, Protein Data Bases

B)

Search and alignment algorithms:

e.g., FASTA, BLAST

Examples of relevant background texts:

1) Bishop, M.J. and C.J. Rawlings (eds.): Nucleic Acid and Protein Sequence

Analysis: A Practical Approach. IRL Press, 1987.

(0I

---

S ?

2) Davies, K.E. (ed.) Genome Analysis: A Practical Approach. IRL Press, 1988.

3)

Hulls, D.M., and C. Moritz. Molecular Systematics. Sinauer Assoc., 1990.

4)

Nei, M. Molecular Evolutionary Genetics. Columbia Univ. Press, 1987.

5)

Li, W-H. and D. Graur. Fundamentals of Molecular Evolution. Sinauér Assoc.,

1991.

6)

Doolittle, R.F. (ed.) Molecular Evolution: Computer Analysis of Protein and

Nucleic Acid Sequences. Methods in Enzymology: Vol. 183. Academic

Press, 1990.

b)

Competence of Faculty:

Both listed faculty have been publishing internationally recognized research

in the area of molecular evolution for over 10 years. They have both been elected

as Associates in the prestigious Program of Evolutionary Biology of the Canadian

Institute of Advanced Research, have organized national symposia in the area of

molecular evolution, have presented numerous papers on this topic at international

meetings, and routinely review primary research publications for journals such as

Genetics, J. Molec. Evolution, Molecular Biol. & Evol. and others.

c)

Library Resources:

Present library resources, e.g., primary journal sources, review sources,

etc., are adequate for this course.

S

0

IN,

---

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

KBB ?

Course Number: _833-3

Title:

Develo

p

mental Genetics

Description:

Selected To

p

ics in the Develo p

mental Genetics of Drosophila.

Credit Hours:

?

3

?

Vector: 3-0-0

?

Prerequisite(s) if any:

None

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

9-in ?

—When will the course first be offered:— ?

9.6-1

How often will the course be offered:

_Once ever

y two years

JUSTIFICATION:

Application of molecular genetic techni

q

ues to the development of Drosophila has

led_to_a_sri_es_of_hrkthrrigbs_n_tinersrnding_of_revei_oprt_-_

T)evel

genetics is a focus of the K3B graduate program. This course was offered previously

asaSpecialTopicscourse,whichshouldbeformalizedandscheduledonaregularbasis.

It will be part of the YLBB graduate program.

RESOURCES:

Which Faculty member will normally teach the course:

Dr. _James _V._Price

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

Currently _available _library

_resources

are sufficient.

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:

Faculty Graduate Studies Committee: ?

Date:

Faculty: ?

Date:

Senate Graduate Studies Committee:.

?

Date:J

Senate: ?

Date:'

I,

J -

/'

ff,

---

Appendix A.

MBB 833

?

.

Course Outline

This course will meet two times per week. Each meeting will be approximately 1.5 hours.

Original research articles from the current literature will be assigned as required reading.

The assigned articles will be discussed during class meetings. Short essays (less than one

page) discussing the assigned articles will be required after each class meeting.

Since the course is based on current literature, the specific content will vary. However the

course will follow the general progression indicated below.

Weeks 1- 4

Drosophila

Ooaenesis:the establishment of pattern in the egg.

Weeks 5 - 8

Drosophila

Embryogenesis: interpretation of the maternally imposed pattern

and implementation of embryonic cell fates.

Weeks 9 - 12 Neurogenesis and eye development in

Drosophila.

Week 13 Imaginal disks in

Drosophila

development.

Competence of the Instructor

Dr. Price received graduate training in molecular

biology and nucleic acid biochemistry from Nobel Laureate

Tom Cech. He then carried out postdoctoral research at

Princeton U. on the molecular and developmental genetics of

oogenesis and pattern formation in Drosophila, the most

advanced model of animal development. His research, which

has been published in leading journals (e.g.,

Science, Cell,

J. Mol. Biol.),

focuses on the subject matter of this course

and is funded by NSERC and MRC.

Library resources: This course will not require the acquisition of any new library

resources. The course will be based on original research articles from the current literature.

The journals that will be useful are alread

y

available in the library. The following serials

will be used in the course:

Cell

Development

Developmental Biology

Genes and Development

Genetics

EN4B 0 Journal

Nature

Proceeding of the National Academy of Sceinces (USA)

Roux's Archive of Developmental Biology

Science

L

W

---

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

PROGRAM:

DeçxzRt:

_Molecular Biology and Biochemistry

?

Course Number:

_MBB 834

Title:

Topics in Developmental Biology

Description:

Consideration of selected contemporary topics including pattern formation,

inorphogenetic determinants, inductive interactions, and regulation of gene expression.

Credit Hours:

?

3

?

Vector:

3-0-0 ?

Prerequisite(s) if any:

BISC_303._321_or

equivalent

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:_

5

. 0

_When will the course first be offered: 97-1

How often will the course be offered: In_1trnating_

yerc.

JUSTIFICATION:

Developmental biology is one of the most active disciplines in the biological sciences

5

?

and is a focus of the IKBB research programs. This course has been irregularly offered

asaspecialtopicscourse,butshouldbeformalizedandofferedonaregularbasis.

It will be part of the MEB graduate program. Complements MBB 833c:

RESOURCES:

Which Faculty member will normally teach the course:

_Dr. Bruce Brandhorst

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:

.'2-<77Z_

L

?

Faculty Graduate Studies Committee:

Faculty:

?

Date:

\) \

Senate Graduate Studies Committee:

Senate: ?

Date:

S

---

MBB 834-3

TOPICS IN DEVELOPMENTAL BIOLOGY

?

S

Instructor:

Prof. Bruce P. Brandhorst

Prerequisites:

Students should have the equivalent of BISC 333 (formerly 203),

DEVELOPMENTAL BIOLOGY, and BISC 321 INTRODUCTION TO

MOLECULAR BIOLOGY. Students uncertain about these prerequisite

courses should seek permission of the instructor.

Course format and outline:

This course will consider importantcontemporary topics in

developmental biology, concentrating on the recent literature. The course

will consist of lectures and seminars presented by the instructor and

students as well as discussions. In addition, some speakers in the IMBB

seminar series will be invited to meet with students to discuss their

research. The topics will vary from year to year and will evolve with the

literature but are likely to include the following:

?

5

1.

Overview of pattern formation in insects: nature of morphogens and

morphogenetic gradients, establishment of axes of polarity,

segmentation, and establishment of segment identities.

2.

Establishment of axes of polarity in other embryos, especially

vertebrates.

3.

The nature and role of inductive interactions in various embryos

including frogs, ascidians, sea urchins, and nematodes.

4.

Analysis of genes involved in cellular determination and differentiation.

Examples may include: myogenic transcription factors in vertebrates; the

nature and function of genes involved in binary cell fate decisions; and

genes involved in sex determination.

5.

Regulation of gene expression during embryonic development.

Transcriptional regulation in differentiating cells. Several examples of

post-transcriptional regulation will be examined, generally in connection

with other topics. Mechanisms which result in stable patterns of

specialized gene expression will be considered.

6.

Developmental mechanisms of evolutionary -change.

..

LE

V.

---

0 ?

MBB

834-3 ?

Topics in Developmental Biology

Readings:

Recent research reports and review articles will be assigned. Useful

background reading will be found in the following books:

1. Developmental Biology,

Scott F. Gilbert. Sinauer. (Fourth edition,

1994).

2. Developmental Biology,

L.W. Browder, C.A. Erickson, and W.R. Jeffery.

Saunders College (Third edition, 1991).

3.

From Egg to Embryo,

J.M.W. Slack. Cambridge Univ. Press (Second

edition, 1991).

4. The Making of a Fly,

Peter A. Lawrence. Blackwell Scientific

Publications (1992).

5.

Gene Activity in Early Development,

Eric H. Davidson. Academic Press

(Third Edition, 1986).

Evaluation:

•

?

?

Students will be evaluated on the basis of their seminars, several

written reports, and participation in discussions. A formal examination may

be given.

Comøetence of the Instructor

Dr. Brandhorst has carried out research on the development of

?

embryos for over 25 years. He publishes in, and reviews manuscripts for,

the leading journals in his field (e.g.,

Developmental Biology, Development,

and

Genes and Development).

He has served on the Editorial Board of

Cell

and Molecular Biology

and is Associate Editor of

Molecular Reproduction

and Development. He is currently a member of the NSERC Cell Biology

GSC, representing developmental biologists. From 1980-1987 he taught

and directed an international graduate training program in developmental

biology at the Marine Biological Laboratory, Woods Hole. He taught a

similar course at McGill University for 16 years.

Library Resources:

The library has an adequate collection of serials and books related to

the topic of the course. Assigned readings will be drawn from these

holdings. The Instructor has personal subscriptions to some important

serials not included the Library collection, and will make these available to

stu

dents.

4

^7.

---

r

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Molecular Biology and Biochemistry

?

Course Number:

_M

B

B 85—

Title: ?

Genome Analysis

Description:

The course will consider recent literature. Students will present seminars

and carry out projects on computer—based analysis of genornic sequence data. A familiarity

with the Unix o

p eratin g s

y

stem is essential

Credit Hours:

?

I ?

Vector:_3-0-0

?

Prerequisite(s) if any:

_BTS( 4

0

7 nr

eguivalenl

ENROLLMENT AND SCHEDULING:

Estimated Enrollment: ?

5 - 10 When will the course first be offered: 96-2

How often will the course be offered:

_EverY

second year

JUSTIFICATION:

Large scale genomic secuencin

g

proects are under vy

Pnd will prrir'e }iige

?

ounts

of new information. This course will help students learn to manage that data. It will

be part of the NBB graduate program. It is part of the focus on

mo1érii1r pvn1iit-irn

RESOURCES:

Which Faculty member will normaily teach the course:

?

flr

T)v 4

T -

What are the budgetary implications of mounting the course:

?

None

Are there sufficient Library resources (append details): -_

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee

Faculty Graduate Studies Committee:

?

Date:

Faculty ?

c-)

Date:

_

I

Senate Graduate Studies Com

mi ttee.c

.

.

?

DateJ '/9

Senate:

---

a) Course Outline

S

MBB 835-3?

GENOME ANALYSIS

The course will consider recent literature. Students will present

seminars and carry out projects on computer-based analysis of genomic

sequence data. A familiarity with the Unix operating system is essential.

TOPICS

1. High resolution physical maps of eukaryotic genomes.

a.

"Philosophical" and practical considerations: refinement of maps

prior to DNA sequencing.

b.

Methods of map construction. Approaches adopted for S.

cerevisiae, D. melanogaster, C. elegans,

mice and humans.

c.

Use of Expressed Sequence Tags (ESTs) and Sequence Tagged

Sites (STSs).

2. Sequencing genomic DNA

a.

The relevance and utility of "model" organisms and development of

sequencing strategies.

b.

Methods for handling DNA sequence.output (Staden utilities such

as XBAP. etc.)

3. Analysis of genomic DNA sequence

a.

Database searches:

I. Algorithms

ii. Useful database servers

b. Presentation and retrieval of data: e.g., ACeDB.

c.

Comparative sequence analysis.

d. Identification of genes.

4. Exploitation of sequenced genomes.

a.

How will the information by used by biologists.

b.

Methodologies and strategies.

c. Opportunities for the study of genomic organization, function, and

evolution.

5. Complementary approaches: alternate methods for analysis of eukaryotic

g en o me s.

b) Competence of the Instructor

Prof. Baillie was trained as a geneticist at UBC, U. Connecticut, and

Cambridge U. His research concerns high resolution mapping of genomes

and is supported by NSERC, NIH, the CGAT genome project, and the

Muscular Dystrophy Association. Regarded as a leading Canadian

geneticist, he has served recently on MRC and NSERC grant selection

committees, and is an Associate Editor of

Genome.

Much of his current

research is related to the global effort to map and sequence the genome of

.

Pot

---

• ?

C.

elegans,

a

project serving as a model for the massive Human Genome

Project. A critical aspect of these projects will be the management and

utilization of the data produced, a focus of this course.

c) Library Resources

With the addition of

Nature Genetics,

the leading journal relevant to

the course, the serials collection is adequate. On-line databases accessed

on the Internet, or databases stored on the IMBB network server, will be

used extensively.

.

S

-:1-0

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SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

.

CALENDAR INFORMATION

Program:

Jent: ?

KBB ?

Course Number: 836-3

Title: ?

Gene Expression

Description:

A consideration of the mechanisms and

reulation

of

g

ene expression in

eukar

y ot e

s and prokaryotes.

Credit Hours

?

3

?

Vector: 3-0-0

?

Prerequisite(s)

if

any:

None

n

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:-..71-2-When will the course first be offered:---96----3

How often will the course be offered:

_Every 2years

JUSTIFICATION:

New

MBB

graduate program. The topic is the essence of molecular biology. A

similar course has been offered Previousl

y

as a sRecial topics BISC course,

RESOURCES:

Which Faculty member will normally teach the course:

Dr. _

B.

_Honda

What are the budgetary implications of mounting the course:

?

None

Are there sufficient Library resources (append details):

Adequate,

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:

Faculty Graduate Studies

_Uate:_____________

Committee:

Faculty:

?

3 ?

Date:

________________ C Jr

Senate Graduate Studies Committee:

?

\ ?

Date: ) ••

?

1i

Senate: ?

Jl ?

Date:_____________

---

a)

Course Outline

MBB836-3

GENE EXPRESSION

Instructor: ?

Dr. Barry M. Honda

Office: SSB 7140

Reference material:

?

Genes and Genomes (1991), Singer and Berg, as

well as other texts and current journals.

Course descri

p tion: ?

This course will use the current literature to survey

recent advances in our understanding of how

genes are regulated.

Course outline: ?

Topics to include:

A review of gene structure

An overview of the logic and machinery of gene

expression, levels of regulation.

Genomic rearrangements and gene activity

Transcription as a key regulatory step

Post-transcriptional events: RNA processing,

stability, etc.

Translational regulation

Post-translational mechanisms

b)

Instructor competence:

Trained as a molecular biologist at UBC, Washington U., and MRC

(Cambridge), Dr. Honda's research training and current interests concern

mechanisms of transcription and the regulation of gene expression in animal

cells. His research concerns RNA polymerase Ill and the structural features

of chromosome which influence gene activity. He currently serves on the

NSERC Molecular Genetics grant committee. He covers several of the

topics at a lower level of sophistication in his courses BISC 321 and 431.

He recently offered a similar special topics BISC graduate course.

c)

Library resources:

The library has copies of Singer and Berg, as well as a modest

collection of journals representing this area. With the proximity of the good

UBC collection, the library resources are adequate.

1

.

1.

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-J

.

.

.

SIMON FRASER UNIVERSITY

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Pro gr am

M B ?

Course Number: _837-3

Title:

Molecular Genetics of Signal Transduction

Description:

Consideration of mechanisms of signal transduction using molecular genetic

approaches with emphasis on the yeast Saccharomyces cerevisiae.

Credit Hours:

?

3

?

Vector: 3-0-0

?

Prerequisite(s)

if

any:

?

None

ENROLLMENT. AND SCHEDULING:

Estimated Enrollment:

_E-1?

—

When

will the course first be offered:

?

96

How often will the course be offered:

JUSTIFICATION:

This course will be part of the new graduate program in molecular biology and

biochemistry. Cellular si

g

nalling/si

g

nal transduction is an eMDhasis of IMBB research

and a leading research front. Yeast offers unique

-

advanta

g

es for molecular geneticists

and biotechnologists. Offered in

94-1

as BISC 861.

RESOURCES:

Which Faculty member will normally teach the course:

_Dr. _Charlie Boone

What are the budgetary implications of mounting the course:

Non?

Are there sufficient Library resources (append details):

?

Yes.

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

Approved: Departmental Graduate Studies Committee:

Faculty Graduate Studies Committee: _Date:_

Faculty:

_.

?

\Date:_\/_

I_)

Senate Graduate Studies Committee:-

?

DateA

Senate: ?

Date:

---

A)

Outline of the Course

MBB 837-3

MOLECULAR GENETICS OF SIGNAL TRANSDUCTION

Instructor: ?

Charlie Boone

Course description:

?

Consideration of mechanisms of signal

transduction using molecular genetic approaches

with emphasis on the yeast

Saccháromyces

cerevisiae.

Course outline: ?

This course will involve a cUrreçt literature survey

of the recent advances in signal transduction with

a special emphasis on the yeast

Saccharomyces

cere visiae.

Topics to include:

G protein-coupled receptors

RAS signaling pathway

Mitotic cell division control

B)

Instructor's competence:

Dr. Boone received his graduate training at McGill University in the

molecular genetics of yeast, a very important research model of éukaryotic

cells. His thesis research was published in several highly selective journals

(e.g.,

Cell, J. Cell Biology, Nucleic Acids Research).

He initiated his current

research program on signal transduction mechanisms in yeast as a

postdoctoral fellow at the Institute of Molecular Biology at the University of

Oregon. Since his arrival at SFU he has twice taught this course as a

special topics BISC graduate course, which has been well received.

C)

Library resources:

The library contains all the journals required.

.

.

0

^4

---

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

S

CALENDAR INFORMATION:

?

Molecular Biolog y and Biochemistr

y

?

Course Number:

_MBB

839-3

Tide:

Special Topics in Molecular Biology

Description:

A detailed consideration of a selected important topics in molecular, cellular,

and developmental biolo

gy

and genetics.

Credit Hours:

?

3

?

Vector: 3-0-0

?

Prerequisite(s) if any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

_5—I C)

When will the course first be offered:

TRA

How often will the course be offered:

Intermittently, asreuired.

JUSTIFICATION:

This course

p

rovides an opportunit y

to quickly mount a new graduate course in An

S

?

emerging research front or in accordance with special opportunities, such as the

arrival of a new faculty member. It will be part of the MBB graduate program.

RESOURCES:

Which Faculty member will normally teach the course:

_TEA

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An

indication

of the competence of the Faculty member to give the course.

c)

Library resources

S

Approved:

Departmental Graduate Studies Committee

Faculty Graduate Studies Committee:____

Faculty:

Senate Graduate Studies Committee:_____

Senate:

Date: \)

I

- /

r'

---

I

V

?

r-

MBB 839-3

SPECIAL TOPICS IN MOLECULAR BIOLOGY

Instructor:

To be selected from among the staff of the Graduate Program in

Molecular Biology and Biochemistry.

Outline:

A detailed consideration of recent literature concerning important

contemporary topics in molecular, cellular, and developmental biology and

genetics. Topics will change from year to year, and this course can be taken

more than once with permission of the instructor. The topics will not be

covered in depth in other MBB graduate course offerings. This course

allows an opportunity to quickly provide graduate instruction in newly

developing areas of research or in response to special circumstances, such

as the presence of a new or visiting faculty member. The instructor(s) will

decide on the format of the course, with the approval of the MBB Graduate

Program Committee.

Com

p

etence of the Instructor:

The course will be offered by an Instructor having research expertise

in or specialized knowledge of the topic covered.

?

0.

Library

Resources:

The current books and serials collection is adequate.

---

Ctw

'17

/((c

.(\-

?

-

I

SIMON FRASER UNIVERSITY

?

NEW GRADUATE COURSE PROPOSAL

CALENDAR INFORMATION:

Mn1

p

rii1r Biology Pnt

j

Birrheistry ?

Course Number:

_MTRR

971,822,873

Title:

Directed Readings in Molecular Biology and Biochemistry

Description:

Programs of directed readings and critical discussions based on the educational

oals of individual students.

Credit Hours:

1. 2, 3, respectively

Vector: _O.-6,Q

?

Prerequisite(s)

if

any:

ENROLLMENT AND SCHEDULING:

Estimated Enrollment:

_1 -3 ?

When will the course first be offered:

_TEA

How often will the course be offered:

_Intermittent

lv

as needed.

JUSTIFICATION:

The course is designed to provide a directed educational experience for students

'10 ?

when formal graduate courses are not available which cover the sublect matter, but

there is facult

y

expertise. Tr

will he n p rt -

of t-He vRR

gra.duate_px.ogrrn.

RESOURCES:

\Vhich Faculty member will normally teach the course:

?

TBA

What are the budgetary implications of mounting the course:

None

Are there sufficient Library resources (append details):

?

Yes

Appended: a) Outline of the Course

b)

An indication of the competence of the Faculty member to give the course.

c)

Library resources

.

Approved:

Departmental Graduate Studies Committee:

Faculty Graduate Studies Committee:

Faculty:

Senate Graduate Studies Committee:

Senate:

---

MBB 871-1, MBB 872-2, MBB, 873-3

?

DIRECTED READINGS IN MOLECULAR BIOLOGY AND BIOCHEMISTRY.

Programs of directed readings and critical discussions offered by staff

members to an individual student (or small group of students) to achieve the

specific educational goals of the student. A program of reading, discussion,

and evaluation will be developed for each course offered. Each study

program must be approved by the MBB Graduate Program Committee.

Com

p

etence of the Instructor:

Instructors will be selected on the basis of their expertise in the

subject matter of the course.

Library Resources:

The resources of the library are adequate. Use of interlibrary loans

will permit acquisition of appropriate serials not included in the collection.

I

.